{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T16:50:07Z","timestamp":1780937407861,"version":"3.54.1"},"reference-count":17,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2021,12,29]],"date-time":"2021-12-29T00:00:00Z","timestamp":1640736000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Allergic bronchopulmonary aspergillosis (ABPA) is a pulmonary disorder occurring in response to Aspergillus fumigatus that can complicate the course of asthma and cystic fibrosis. Here we present a case of acute ABPA without central bronchiectasis, a case of chronic active ABPA with central bronchiectasis, and a case of severe relapsing ABPA with central bronchiectasis. All three were initially treated with corticosteroids and antifungal agents but had an incomplete response. These patients were then treated with anti-IgE therapy with omalizumab before being switched to the anti-IL5R agent benralizumab. They responded well to both agents. These case reports highlight the potential role of omalizumab and benralizumab in the treatment of ABPA, but further studies are required to evaluate the effectiveness of these medications. Longer follow-up periods and objective measurements of the impact of treatment are necessary.<\/jats:p>","DOI":"10.3390\/medicina58010053","type":"journal-article","created":{"date-parts":[[2021,12,29]],"date-time":"2021-12-29T23:31:35Z","timestamp":1640820695000},"page":"53","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["The Use of Targeted Monoclonal Antibodies in the Treatment of ABPA\u2014A Case Series"],"prefix":"10.3390","volume":"58","author":[{"given":"Aoife","family":"O\u2019Reilly","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine, St. Vincent\u2019s University Hospital, Elm Park, D04 T6F4 Dublin, Ireland"},{"name":"School of Medicine, University College Dublin, Belfield, D04 V1W8 Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleanor","family":"Dunican","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, St. Vincent\u2019s University Hospital, Elm Park, D04 T6F4 Dublin, Ireland"},{"name":"School of Medicine, University College Dublin, Belfield, D04 V1W8 Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,12,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1111\/cea.12141","article-title":"Allergic bronchopulmonary aspergillosis: Review of literature and proposal of new diagnostic and classification criteria","volume":"43","author":"Agarwal","year":"2013","journal-title":"Clin. Exp. Allergy"},{"key":"ref_2","first-page":"936","article-title":"Aspergillus hypersensitivity and allergic bronchopulmonary aspergillosis in patients with bronchial asthma: Systematic review and meta-analysis","volume":"13","author":"Agarwal","year":"2009","journal-title":"Int. J. Tuberc. Lung Dis."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1183\/13993003.01475-2015","article-title":"A randomised trial of glucocorticoids in acute-stage allergic bronchopulmonary aspergillosis complicating asthma","volume":"47","author":"Agarwal","year":"2015","journal-title":"Eur. Respir. 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Chemother."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"423","DOI":"10.3109\/02770903.2012.662568","article-title":"Voriconazole and Posaconazole Improve Asthma Severity in Allergic Bronchopulmonary Aspergillosis and Severe Asthma with Fungal Sensitization","volume":"49","author":"Chishimba","year":"2012","journal-title":"J. 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