{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T22:15:40Z","timestamp":1791238540984,"version":"4.1.0"},"reference-count":43,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2022,1,10]],"date-time":"2022-01-10T00:00:00Z","timestamp":1641772800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>The coronavirus disease 2019 (COVID-19) pandemic has brought significant challenges to many aspects of healthcare delivery since the first reported case in early December 2019. Once in the body, SARS-CoV-2 can spread to other digestive organs, such as the liver, because of the presence of ACE2 receptors. Colorectal cancer (CRC) remains the second-leading cause of death in the United States (US). Therefore, individuals are routinely screened using either endoscopic methods (i.e., flexible sigmoidoscopy and colonoscopy) or stool-based tests, as per the published guidelines. At the beginning of the COVID-19 pandemic, the Centers for Medicare and Medicaid Services (CMS) recommended that all non-urgent surgical and medical procedures, including screening colonoscopies, be delayed until the pandemic stabilization. This article aims to review the impact of COVID-19 on CRC screening.<\/jats:p>","DOI":"10.3390\/medicina58010100","type":"journal-article","created":{"date-parts":[[2022,1,9]],"date-time":"2022-01-09T23:35:09Z","timestamp":1641771309000},"page":"100","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Global Impact of COVID-19 on Colorectal Cancer Screening: Current Insights and Future Directions"],"prefix":"10.3390","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5934-2695","authenticated-orcid":false,"given":"Jonathan","family":"Kopel","sequence":"first","affiliation":[{"name":"Department of Medicine, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bojana","family":"Ristic","sequence":"additional","affiliation":[{"name":"Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4764-1844","authenticated-orcid":false,"given":"Gregory L.","family":"Brower","sequence":"additional","affiliation":[{"name":"Department of Medication Education, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9433-9042","authenticated-orcid":false,"given":"Hemant","family":"Goyal","sequence":"additional","affiliation":[{"name":"The Wright Center for Graduate Medical Education, Scranton, PA 18501, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,1,10]]},"reference":[{"key":"ref_1","first-page":"1932","article-title":"Clinical Insights into the Gastrointestinal Manifestations of COVID-19","volume":"65","author":"Kopel","year":"2020","journal-title":"Am. J. Dig. Dis."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.ijid.2020.03.004","article-title":"The SARS-CoV-2 outbreak: What we know","volume":"94","author":"Wu","year":"2020","journal-title":"Int. J. Infect. Dis."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1038\/s41586-020-2008-3","article-title":"A new coronavirus associated with human respiratory disease in China","volume":"579","author":"Wu","year":"2020","journal-title":"Nature"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/S0140-6736(20)30211-7","article-title":"Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: A descriptive study","volume":"395","author":"Chen","year":"2020","journal-title":"Lancet"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1007\/s12519-020-00356-2","article-title":"Clinical features of pediatric patients with COVID-19: A report of two family cluster cases","volume":"16","author":"Ji","year":"2020","journal-title":"World J. Pediatr."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1730","DOI":"10.1111\/all.14238","article-title":"Clinical characteristics of 140 patients infected with SARS-CoV-2 in Wuhan, China","volume":"75","author":"Zhang","year":"2020","journal-title":"Allergy"},{"key":"ref_7","unstructured":"(2022, January 03). Joint GI Society Message: COVID-19 Clinical Insights for Our Community of Gastroenterologists and Gastroenterology Care Providers. Available online: https:\/\/gastro.org\/press-releases\/joint-gi-society-message-covid-19-clinical-insights-for-our-community-of-gastroenterologists-and-gastroenterology-care-providers\/."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1186\/gb-2003-4-8-225","article-title":"Angiotensin-I-converting enzyme and its relatives","volume":"4","author":"Riordan","year":"2003","journal-title":"Genome Biol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1053\/j.gastro.2020.02.055","article-title":"Evidence for gastrointestinal infection of SARS-CoV-2","volume":"158","author":"Xiao","year":"2020","journal-title":"Gastroenterology"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/s41586-020-2012-7","article-title":"A pneumonia outbreak associated with a new coronavirus of probable bat origin","volume":"579","author":"Zhou","year":"2020","journal-title":"Nature"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.cell.2020.02.052","article-title":"SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor","volume":"181","author":"Hoffmann","year":"2020","journal-title":"Cell"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"145","DOI":"10.3322\/caac.21601","article-title":"Colorectal cancer statistics, 2020","volume":"70","author":"Siegel","year":"2020","journal-title":"CA Cancer J. Clin."},{"key":"ref_13","first-page":"105","article-title":"Longitudinal adherence to colorectal cancer screening guidelines","volume":"22","author":"Cyhaniuk","year":"2016","journal-title":"Am. J. Manag. Care"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.7326\/0003-4819-150-1-200901060-00306","article-title":"Association of Colonoscopy and Death From Colorectal Cancer","volume":"150","author":"Baxter","year":"2009","journal-title":"Ann. Intern. Med."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Heitman, S.J., Hilsden, R.J., Au, F., Dowden, S., and Manns, B.J. (2010). Colorectal cancer screening for average-risk North Americans: An economic evaluation. PLoS Med., 7.","DOI":"10.1371\/journal.pmed.1000370"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1056\/NEJM199305133281901","article-title":"Reducing Mortality from Colorectal Cancer by Screening for Fecal Occult Blood","volume":"328","author":"Mandel","year":"1993","journal-title":"N. Engl. J. Med."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1053\/j.gastro.2020.11.014","article-title":"Colonoscopy With Polypectomy Reduces Long-Term Incidence of Colorectal Cancer in Both Men and Women: Extended Results From the Minnesota Colon Cancer Control Study","volume":"160","author":"Shaukat","year":"2021","journal-title":"Gastroenterology"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.1001\/jama.2021.6238","article-title":"Screening for Colorectal Cancer: US Preventive Services Task Force Recommendation Statement","volume":"325","author":"Force","year":"2021","journal-title":"JAMA"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"e216454","DOI":"10.1001\/jamanetworkopen.2021.6454","article-title":"Model-Based Estimation of Colorectal Cancer Screening and Outcomes During the COVID-19 Pandemic","volume":"4","author":"Issaka","year":"2021","journal-title":"JAMA Netw. Open"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"553589","DOI":"10.3389\/fpubh.2020.553589","article-title":"The Necessity of Stool Examination in Asymptomatic Carriers as a Strategic Measure to Control Further Spread of SARS-CoV-2","volume":"8","author":"Mirjalali","year":"2020","journal-title":"Front. Public Health"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1016\/j.pan.2020.05.003","article-title":"COVID-19 presenting as acute pancreatitis","volume":"20","author":"Aloysius","year":"2020","journal-title":"Pancreatology"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Dennis, L.K., Hsu, C.-H., and Arrington, A.K. (2021). Reduction in Standard Cancer Screening in 2020 throughout the U.S. Cancers, 13.","DOI":"10.3390\/cancers13235918"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1007\/s10151-020-02209-6","article-title":"Italian society of colorectal surgery recommendations for good clinical practice in colorectal surgery during the novel coronavirus pandemic","volume":"24","author":"Gallo","year":"2020","journal-title":"Tech. Coloproctol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.1111\/jgh.15325","article-title":"Impact of COVID-19 pandemic on fecal immunochemical test screening uptake and compliance to diagnostic colonoscopy","volume":"36","author":"Cheng","year":"2020","journal-title":"J. Gastroenterol. Hepatol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/j.amsu.2020.11.087","article-title":"The number of obstructive colorectal cancers in Japan has increased during the COVID-19 pandemic: A retrospective single-center cohort study","volume":"60","author":"Mizuno","year":"2020","journal-title":"Ann. Med. Surg."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1053\/j.gastro.2020.05.037","article-title":"Impacts of the Coronavirus 2019 Pandemic on Gastrointestinal Endoscopy Volume and Diagnosis of Gastric and Colorectal Cancers: A Population-Based Study","volume":"159","author":"Lui","year":"2020","journal-title":"Gastroenterology"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1002\/ijc.33500","article-title":"Cross-sectional survey of the impact of the COVID-19 pandemic on cancer screening programs in selected low- and middle-income countries: Study from the IARC COVID-19 impact study group","volume":"149","author":"Villain","year":"2021","journal-title":"Int. J. Cancer"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1111\/codi.15622","article-title":"The impact of the first peak of the COVID-19 pandemic on colorectal cancer services in England and Wales: A national survey","volume":"23","author":"Boyle","year":"2021","journal-title":"Colorectal. Dis."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S2468-1253(21)00005-4","article-title":"Impact of the COVID-19 pandemic on the detection and management of colorectal cancer in England: A population-based study","volume":"6","author":"Morris","year":"2021","journal-title":"Lancet Gastroenterol. Hepatol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"e5","DOI":"10.1016\/j.clcc.2020.07.006","article-title":"Impact of COVID-19 Pandemic on Colorectal Cancer Screening Program","volume":"20","author":"Lucidi","year":"2021","journal-title":"Clin. Colorectal. Cancer"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1080\/14737159.2021.1860760","article-title":"Exploring the real-world effect of the SARS-CoV-2 pandemic on the molecular diagnostics for cancer patients and high-risk individuals","volume":"21","author":"Cavic","year":"2021","journal-title":"Expert Rev. Mol. Diagn."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1001\/jamaoncol.2021.0884","article-title":"Association of Cancer Screening Deficit in the United States With the COVID-19 Pandemic","volume":"7","author":"Chen","year":"2021","journal-title":"JAMA Oncol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1111\/codi.15618","article-title":"Short-term outcomes of a COVID-adapted triage pathway for colorectal cancer detection","volume":"23","author":"Miller","year":"2021","journal-title":"Colorectal. Dis."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1053\/j.gastro.2021.04.026","article-title":"Noninvasive Colorectal Cancer Screening Tests Help Close Screening Gaps During Coronavirus Disease 2019 Pandemic","volume":"161","author":"Myint","year":"2021","journal-title":"Gastroenterology"},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Kruse-Diehr, A.J., Dignan, M., Cromo, M., Carman, A.L., Rogers, M., Gross, D., and Russell, S. (2021). Building Cancer Prevention and Control Research Capacity in Rural Appalachian Kentucky Primary Care Clinics During COVID-19: Development and Adaptation of a Multilevel Colorectal Cancer Screening Project. J. Cancer Educ., 1\u20137.","DOI":"10.1007\/s13187-021-01972-w"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/S2468-1253(21)00003-0","article-title":"Impact of the COVID-19 pandemic on faecal immunochemical test-based colorectal cancer screening programmes in Australia, Canada, and the Netherlands: A comparative modelling study","volume":"6","author":"Worthington","year":"2021","journal-title":"Lancet Gastroenterol. Hepatol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1136\/gutjnl-2020-321650","article-title":"Prioritisation by FIT to mitigate the impact of delays in the 2-week wait colorectal cancer referral pathway during the COVID-19 pandemic: A UK modelling study","volume":"70","author":"Loveday","year":"2021","journal-title":"Gut"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1016\/j.surg.2020.11.008","article-title":"DElayed COloRectal cancer care during COVID-19 Pandemic (DECOR-19): Global perspective from an international survey","volume":"169","author":"Santoro","year":"2021","journal-title":"Surgery"},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"COVIDSurg Collaborative (2020). Outcomes from elective colorectal cancer surgery during the SARS-CoV-2 pandemic. Colorectal. Dis., 23, 732\u2013749.","DOI":"10.1111\/codi.15431"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"238","DOI":"10.4251\/wjgo.v13.i4.238","article-title":"Colorectal cancer screening in the COVID-19 era","volume":"13","author":"Kadakuntla","year":"2021","journal-title":"World J. Gastrointest. Oncol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1622","DOI":"10.1111\/codi.15408","article-title":"Adoption of faecal immunochemical testing for 2-week-wait colorectal patients during the COVID-19 pandemic: An observational cohort study reporting a new service at a regional centre","volume":"23","author":"Maclean","year":"2020","journal-title":"Colorectal. Dis."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1016\/S1470-2045(20)30392-2","article-title":"Effect of delays in the 2-week-wait cancer referral pathway during the COVID-19 pandemic on cancer survival in the UK: A modelling study","volume":"21","author":"Sud","year":"2020","journal-title":"Lancet Oncol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1186\/s13045-020-00984-1","article-title":"The impact of the temporary suspension of national cancer screening programmes due to the COVID-19 epidemic on the diagnosis of breast and colorectal cancer in the Netherlands","volume":"13","author":"Dinmohamed","year":"2020","journal-title":"J. Hematol. Oncol."}],"container-title":["Medicina"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1648-9144\/58\/1\/100\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T14:14:42Z","timestamp":1760364882000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1648-9144\/58\/1\/100"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,10]]},"references-count":43,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2022,1]]}},"alternative-id":["medicina58010100"],"URL":"https:\/\/doi.org\/10.3390\/medicina58010100","relation":{},"ISSN":["1648-9144"],"issn-type":[{"value":"1648-9144","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,10]]}}}