{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T00:44:24Z","timestamp":1760402664430,"version":"build-2065373602"},"reference-count":38,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2022,1,11]],"date-time":"2022-01-11T00:00:00Z","timestamp":1641859200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Gda\u0144sk Medical University","award":["The article was financed up to 10% with financial sources of the Department of Paediatrics, Haematology and Oncology, Medical University of Gdansk (No ST 02-0008\/07)."],"award-info":[{"award-number":["The article was financed up to 10% with financial sources of the Department of Paediatrics, Haematology and Oncology, Medical University of Gdansk (No ST 02-0008\/07)."]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: According to a recent Cochrane systematic review, renal impairment can develop in 0\u201384% of childhood cancer survivors in the future. The renal function impairment in this patient group can be related to nephrectomy, nephrotoxic agents therapy, abdominal radiotherapy, and combinations of these treatment methods. In this study, in a population of patients after anti-neoplastic therapy, with particular emphasis on patients after Wilms\u2019 tumour treatment, we compared new substances which play role in the chronic kidney disease (CKD) pathogenesis (asymmetric dimethylarginine\u2014ADMA, symmetric dimethylarginine\u2014SDMA) with standard renal function markers (e.g., creatinine and cystatin C in serum, creatinine in urine, etc.) to assess the usefulness of the former. Materials and Methods: Eighty-four children, without CKD, bilateral kidney tumours, congenital kidney defects, or urinary tract infections, with a minimum time of 1 year after ending anti-neoplastic treatment, aged between 17 and 215 months, were divided into three groups: group 1\u2014patients after nephroblastoma treatment (n = 21), group 2\u2014after other solid tumours treatment (n = 44), and group 3\u2014after lymphoproliferative neoplasms treatment (n = 19). The patients\u2019 medical histories were taken and physical examinations were performed. Concentrations of blood urea nitrogen (BUN), creatinine, cystatin C, C-reactive protein (CRP), ADMA, and SDMA in blood and albumin in urine were measured, and a general urine analysis was performed. The SDMA\/ADMA ratio, albumin\u2013creatine ratio, and estimated glomerular filtration rate (eGFR) were calculated. eGFR was estimated by three equations recommended to the paediatric population by the KDIGO from 2012: the Schwartz equation (eGFR1), equation with creatinine and urea nitrogen (eGFR2), and equation with cystatin C (eGFR3). Results: Both the eGFR1 and eGFR2 values were significantly lower in group 1 than in group 3 (eGFR1: 93.3 (83.1\u2013102.3) vs. 116.5 (96.8\u2013126.9) mL\/min\/1.73 m2, p = 0.02; eGFR2: 82.7 (\u00b114.4) vs. 94.4 (\u00b111.9) mL\/min\/1.73 m2, p = 0.02). Additionally, there were weak positive correlations between SDMA and creatinine (p &lt; 0.05, r = 0.24), and cystatin C (p &lt; 0.05, r = 0.32) and weak negative correlations between SDMA and eGFR1 (p &lt; 0.05, r = \u22120.25), eGFR2 (p &lt; 0.05, r = \u22120.24), and eGFR3 (p &lt; 0.05, r = \u22120.32). Conclusions: The usefulness of ADMA and SDMA in the diagnosis of renal functional impairment should be assessed in further studies. eGFR, calculated according to equations recommended for children, should be used in routine paediatric practice.<\/jats:p>","DOI":"10.3390\/medicina58010108","type":"journal-article","created":{"date-parts":[[2022,1,11]],"date-time":"2022-01-11T20:33:04Z","timestamp":1641933184000},"page":"108","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dimethylarginines in Children after Anti-Neoplastic Treatment"],"prefix":"10.3390","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4730-8227","authenticated-orcid":false,"given":"Michalina","family":"Jezierska","sequence":"first","affiliation":[{"name":"Department of Paediatrics, Haematology and Oncology, Faculty of Medicine, Medical University of Gdansk, 7 Debinki Street, 80-211 Gdansk, Poland"},{"name":"Department of Paediatrics, Haematology and Oncology, University Clinical Centre, 7 Debinki Street, 80-952 Gdansk, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Owczarzak","sequence":"additional","affiliation":[{"name":"Department of Clinical Nutrition and Dietetics, Faculty of Health Sciences with Institute of Maritime and Tropical Medicine, Medical University of Gdansk, 7 Debinki Street, 80-211 Gdansk, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8014-4263","authenticated-orcid":false,"given":"Joanna","family":"Stefanowicz","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Haematology and Oncology, Faculty of Medicine, Medical University of Gdansk, 7 Debinki Street, 80-211 Gdansk, Poland"},{"name":"Department of Paediatrics, Haematology and Oncology, University Clinical Centre, 7 Debinki Street, 80-952 Gdansk, Poland"},{"name":"Faculty of Health Sciences, Medical University of Gdansk, 7 Debinki Street, 80-211 Gdansk, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,1,11]]},"reference":[{"key":"ref_1","first-page":"437","article-title":"Health status of Polish children and adolescents after cancer treatment","volume":"177","author":"Panasiuk","year":"2018","journal-title":"Eur. 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