{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T15:32:50Z","timestamp":1785425570542,"version":"3.56.0"},"reference-count":41,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2022,2,12]],"date-time":"2022-02-12T00:00:00Z","timestamp":1644624000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: In osteoporotic fractures of the spine with resulting kyphosis and threatening compression of neural structures, therapeutic decisions are difficult. The posterior vertebral column resection (pVCR) has been described by different authors as a surgical treatment in a single-stage posterior procedure. The aim of this study is to evaluate midterm outcomes of patients treated by pVCR due to severe osteoporotic fractures. Materials and Methods: Retrospective data analysis of all the patients treated for osteoporotic fractures by pVCR from 2012\u20132020 at two centers was performed. Demographic data, visual analog scale (VAS), Frankel scale (FS), Karnofsky performance status (KPS), radiological result and spinal fusion rates were evaluated. Results: A total of 17 patients were included. The mean age was 70 \u00b1 10.2 y. The mean VAS decreased significantly from 7.7 \u00b1 2.8 preoperatively to 3.0 \u00b1 1.6 at last follow-up (p &lt; 0.001) and the segmental kyphosis decreased from 29.4 \u00b1 14.1\u00b0 to 7.9 \u00b1 8.0\u00b0 (p &lt; 0.001). The neurologic function on the FS did not worsen in any and improved in four of the patients. The median KPS remained stable over the whole observation period (70% vs. 70%). Spinal fusion was observed in nine out of nine patients who received CT follow-up &gt;120 days after index surgery. Conclusions: This study showed that pVCR is a safe surgical technique with few surgical complications and no neurological deterioration considering the cohort. The patients\u2019 segmental kyphosis and VAS improved significantly, while the KPS remained stable.<\/jats:p>","DOI":"10.3390\/medicina58020277","type":"journal-article","created":{"date-parts":[[2022,2,13]],"date-time":"2022-02-13T20:34:45Z","timestamp":1644784485000},"page":"277","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Outcome after Posterior Vertebral Column Resection in Patients with Severe Osteoporotic Fractures\u2014A Retrospective Analysis from Two Centers"],"prefix":"10.3390","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3966-8537","authenticated-orcid":false,"given":"Leon-Gordian","family":"Koepke","sequence":"first","affiliation":[{"name":"Division of Spine Surgery, Department of Trauma and Orthopedic Surgery, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukas","family":"Weiser","sequence":"additional","affiliation":[{"name":"Clinic for Trauma, Orthopedics and Plastic Surgery, University Medical Center G\u00f6ttingen, Georg-August-Universit\u00e4t, 37075 G\u00f6ttingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Stangenberg","sequence":"additional","affiliation":[{"name":"Division of Spine Surgery, Department of Trauma and Orthopedic Surgery, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1055-8695","authenticated-orcid":false,"given":"Marc","family":"Dreimann","sequence":"additional","affiliation":[{"name":"Division of Spine Surgery, Department of Trauma and Orthopedic Surgery, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annika","family":"Heuer","sequence":"additional","affiliation":[{"name":"Division of Spine Surgery, Department of Trauma and Orthopedic Surgery, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany"},{"name":"Mildred Scheel Cancer Career Center HaTriCS4, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9","family":"Strahl","sequence":"additional","affiliation":[{"name":"Division of Orthopedics, Department of Trauma and Orthopedic Surgery, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lennart","family":"Viezens","sequence":"additional","affiliation":[{"name":"Division of Spine Surgery, Department of Trauma and Orthopedic Surgery, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,2,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1007\/s00198-003-1395-2","article-title":"The hospital cost of vertebral fractures in the EU: Estimates using national datasets","volume":"14","author":"Finnern","year":"2003","journal-title":"Osteoporos. Int."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"793","DOI":"10.7326\/0003-4819-128-10-199805150-00001","article-title":"The association of radiographically detected vertebral fractures with back pain and function: A prospective study","volume":"128","author":"Nevitt","year":"1998","journal-title":"Ann. Intern. Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1007\/s001980050094","article-title":"Report on osteoporosis in the European Community: Current status and recommendations for the future. Working Party from European Union Member States","volume":"8","author":"Compston","year":"1998","journal-title":"Osteoporos. Int."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1093\/bmb\/ldr048","article-title":"Osteoporotic vertebral fractures: Current concepts of conservative care","volume":"102","author":"Longo","year":"2012","journal-title":"Br. Med. Bull."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"102779","DOI":"10.1016\/j.otsr.2020.102779","article-title":"Treatment of osteoporotic vertebral fractures","volume":"107","author":"Prost","year":"2021","journal-title":"Orthop. Traumatol. Surg. Res."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"16","DOI":"10.5455\/msm.2012.24.16-20","article-title":"Effects of conservative treatment for osteoporotic thoracolumbal spine fractures","volume":"24","author":"Talic","year":"2012","journal-title":"Mater. Sociomed."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Lotan, R., Smorgick, Y., Anekstein, Y., Rudik, O., Prosso, I., and Hershkovich, O. (2021). Kyphoplasty for Elderly Patients with Vertebral Compression Fractures-Do We Save Lives? Mortality Rates Analysis Comparison in a Long-Term Follow-Up Cohort. Glob. Spine J.","DOI":"10.1177\/2192568220982282"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1016\/S0140-6736(09)60010-6","article-title":"Efficacy and safety of balloon kyphoplasty compared with non-surgical care for vertebral compression fracture (FREE): A randomised controlled trial","volume":"373","author":"Wardlaw","year":"2009","journal-title":"Lancet"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Dai, S.Q., Qin, R.Q., Shi, X., and Yang, H.L. (2021). Percutaneous vertebroplasty versus kyphoplasty for the treatment of neurologically intact osteoporotic Kummell\u2019s disease. BMC Surg., 21.","DOI":"10.1186\/s12893-021-01057-x"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1016\/j.jos.2019.07.018","article-title":"Surgical outcomes of spinal fusion for osteoporotic vertebral fracture in the thoracolumbar spine: Comprehensive evaluations of 5 typical surgical fusion techniques","volume":"24","author":"Watanabe","year":"2019","journal-title":"J. Orthop. Sci."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Hartensuer, R., Gehweiler, D., Schulze, M., Matuszewski, L., Raschke, M.J., and Vordemvenne, T. (2013). Biomechanical evaluation of combined short segment fixation and augmentation of incomplete osteoporotic burst fractures. BMC Musculoskelet. Disord., 14.","DOI":"10.1186\/1471-2474-14-360"},{"key":"ref_12","first-page":"579","article-title":"Long-term results of kyphoplasty with additive dorsal instrumentation of incomplete burst fractures of the thoracolumbar spine in the elderly","volume":"150","author":"Spiegl","year":"2012","journal-title":"Z. Orthop. Unf."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"46S","DOI":"10.1177\/2192568217717972","article-title":"Classification of Osteoporotic Thoracolumbar Spine Fractures: Recommendations of the Spine Section of the German Society for Orthopaedics and Trauma (DGOU)","volume":"8","author":"Schnake","year":"2018","journal-title":"Glob. Spine J."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"e8895","DOI":"10.1097\/MD.0000000000008895","article-title":"Failed percutaneous kyphoplasty in treatment of stage 3 Kummell disease: A case report and literature review","volume":"96","author":"Zhang","year":"2017","journal-title":"Medicine"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/s10143-017-0840-1","article-title":"Posterior vertebral column resection with 360-degree osteosynthesis in osteoporotic kyphotic deformity and spinal cord compression","volume":"41","author":"Dreimann","year":"2018","journal-title":"Neurosurg. Rev."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"2368","DOI":"10.1007\/s00586-015-3767-7","article-title":"Posterior vertebral column resection in spinal deformity: A systematic review","volume":"25","author":"Yang","year":"2016","journal-title":"Eur. Spine J."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1007\/s00586-012-2150-1","article-title":"360-degree osteosynthesis via a posterolateral transpedicular approach in high-risk patients","volume":"21","author":"Eicker","year":"2012","journal-title":"Eur. Spine J."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1007\/s00064-019-0616-6","article-title":"Posterior vertebral column resection for correction of kyphotic deformity due to osteoporotic fractures of the thoracic spine","volume":"31","author":"Sehmisch","year":"2019","journal-title":"Oper. Orthop. Traumatol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1007\/s00108-008-2138-4","article-title":"The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: Guidelines for reporting of observational studies","volume":"49","author":"Altman","year":"2008","journal-title":"Internist"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1002\/jbmr.5650090802","article-title":"The diagnosis of osteoporosis","volume":"9","author":"Kanis","year":"1994","journal-title":"J. Bone Miner. Res."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1007\/s00701-015-2507-4","article-title":"Retrospective feasibility analysis of modified posterior partial vertebrectomy with 360-degree decompression in destructive thoracic spondylodiscitis","volume":"157","author":"Dreimann","year":"2015","journal-title":"Acta Neurochir."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s00776-005-0964-y","article-title":"Total en bloc spondylectomy for spinal tumors: Improvement of the technique and its associated basic background","volume":"11","author":"Tomita","year":"2006","journal-title":"J. Orthop. Sci."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/0304-3959(94)00178-H","article-title":"When is cancer pain mild, moderate or severe? Grading pain severity by its interference with function","volume":"61","author":"Serlin","year":"1995","journal-title":"Pain"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/sc.1969.30","article-title":"The value of postural reduction in the initial management of closed injuries of the spine with paraplegia and tetraplegia","volume":"7","author":"Frankel","year":"1969","journal-title":"Spinal Cord"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1097\/BSD.0b013e318193e3a5","article-title":"Role of major spine surgery using Kaneda anterior instrumentation for osteoporotic vertebral collapse","volume":"23","author":"Kanayama","year":"2010","journal-title":"J. Spinal Disord. Tech."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"454","DOI":"10.3171\/spi.2006.4.6.454","article-title":"Anterior expandable strut cage replacement for osteoporotic thoracolumbar vertebral collapse","volume":"4","author":"Uchida","year":"2006","journal-title":"J. Neurosurg. Spine"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"S144","DOI":"10.1097\/01.brs.0000236893.65878.39","article-title":"Instrumentation-related complications of multilevel fusions for adult spinal deformity patients over age 65: Surgical considerations and treatment options in patients with poor bone quality","volume":"31","author":"DeWald","year":"2006","journal-title":"Spine"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"2891","DOI":"10.1007\/s00586-017-5091-x","article-title":"Insufficient stability of pedicle screws in osteoporotic vertebrae: Biomechanical correlation of bone mineral density and pedicle screw fixation strength","volume":"26","author":"Weiser","year":"2017","journal-title":"Eur. Spine J."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"2291","DOI":"10.1007\/s00586-014-3414-8","article-title":"The posterior surgical treatment for focal kyphosis in upper-middle thoracic spine","volume":"23","author":"Zeng","year":"2014","journal-title":"Eur. Spine J."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/s00586-016-4805-9","article-title":"Reducing kyphotic deformity by posterior vertebral column resection with 360 degrees osteosynthesis in metastatic epidural spinal cord compression (MESCC)","volume":"26","author":"Dreimann","year":"2017","journal-title":"Eur. Spine J."},{"key":"ref_31","first-page":"87","article-title":"Evaluation of the Normal Range of Thoracic Kyphosis and Lumbar Lordosis Angles Using EOS Imaging","volume":"15","author":"Abrisham","year":"2020","journal-title":"Maedica"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1007\/s00402-011-1439-6","article-title":"A comparative study on screw loosening in osteoporotic lumbar spine fusion between expandable and conventional pedicle screws","volume":"132","author":"Wu","year":"2012","journal-title":"Arch. Orthop. Trauma Surg."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S1529-9430(01)00020-1","article-title":"Lumbosacral fixation using expandable pedicle screws. An alternative in reoperation and osteoporosis","volume":"1","author":"Cook","year":"2001","journal-title":"Spine J."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1097\/BSD.0b013e3180590c23","article-title":"Lumbar decompression and fusion in elderly osteoporotic patients: A prospective study using less rigid titanium rod fixation","volume":"21","author":"Cavagna","year":"2008","journal-title":"J. Spinal Disord. Tech."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1213\/ANE.0000000000001485","article-title":"Spine Surgery and Blood Loss: Systematic Review of Clinical Evidence","volume":"123","author":"Willner","year":"2016","journal-title":"Anesth. Analg."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"257","DOI":"10.4184\/asj.2012.6.4.257","article-title":"Complications of posterior vertebral resection for spinal deformity","volume":"6","author":"Kim","year":"2012","journal-title":"Asian Spine J."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1097\/BRS.0b013e31824fffde","article-title":"Major complications and comparison between 3-column osteotomy techniques in 105 consecutive spinal deformity procedures","volume":"37","author":"Auerbach","year":"2012","journal-title":"Spine"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1007\/s00064-019-0608-6","article-title":"Techniques to increase pedicle screw stability in osteoporotic vertebrae","volume":"31","author":"Weiser","year":"2019","journal-title":"Oper. Orthop. Traumatol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"902","DOI":"10.3171\/jns.1986.64.6.0902","article-title":"Risk factors for postoperative neurosurgical wound infection. A case-control study","volume":"64","author":"Mollman","year":"1986","journal-title":"J. Neurosurg."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1097\/00007632-199803150-00015","article-title":"Factors influencing wound healing after surgery for metastatic disease of the spine","volume":"23","author":"McPhee","year":"1998","journal-title":"Spine"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"E14","DOI":"10.3171\/foc.2003.15.3.14","article-title":"Postoperative wound infections of the spine","volume":"15","author":"Beiner","year":"2003","journal-title":"Neurosurg. Focus"}],"container-title":["Medicina"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1648-9144\/58\/2\/277\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T22:18:10Z","timestamp":1760134690000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1648-9144\/58\/2\/277"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,12]]},"references-count":41,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2022,2]]}},"alternative-id":["medicina58020277"],"URL":"https:\/\/doi.org\/10.3390\/medicina58020277","relation":{},"ISSN":["1648-9144"],"issn-type":[{"value":"1648-9144","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2,12]]}}}