{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T02:50:27Z","timestamp":1760151027782,"version":"build-2065373602"},"reference-count":12,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2022,2,14]],"date-time":"2022-02-14T00:00:00Z","timestamp":1644796800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>The pathogeneses of age-related macular degeneration (AMD) and age-related hearing impairment are not yet fully understood. If AMD and age-related hearing impairment are correlated, the cause of both may be a result of a common vulnerability. The aim of this study was to assess the interrelation between age-related macular degeneration and age-related hearing loss. Material and methods: In our case-control analysis, the hearing conditions of 40 subjects with AMD were compared with 40 age-matched healthy controls. In all patients, retinal changes were certified by clinical examinations, optical coherence tomography (OCT), and fluorescein angiography (FA). All subjects were inspected with pure tone audiometry (PTA), impedance audiometry, and speech audiometry. Results: A significant correlation (p &lt; 0.001) was identified between age-related macular degeneration and age-related hearing impairment. The predominant hearing impairment in this case was sensorineural (SNHL). Of the patients diagnosed with AMD, SNHL was found in 88.89% of those with exudative macular degeneration and in 67.74% of those with atrophic macular degeneration. In contrast, we found that a significant proportion of the control group had normal hearing. Conclusion: One possible explanation for the association between retinal and cochlear impairment may be due to a melanin disorder.<\/jats:p>","DOI":"10.3390\/medicina58020291","type":"journal-article","created":{"date-parts":[[2022,2,14]],"date-time":"2022-02-14T20:58:03Z","timestamp":1644872283000},"page":"291","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Dual Sensory Impairment: The Correlation between Age Related Macular Degeneration and Sensorineural Hearing Loss"],"prefix":"10.3390","volume":"58","author":[{"given":"Marina","family":"Istrate","sequence":"first","affiliation":[{"name":"Department of Doctoral School, \u201cVictor Babes\u201d University of Medicine and Pharmacy, 300041 Timisoara, Romania"},{"name":"Department of Ophthalmology, \u201cInfosan\u201d Ophthalmology Clinic, 010538 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mihai","family":"Hasbei-Popa","sequence":"additional","affiliation":[{"name":"Department of Medicine, \u201cIuliu Hatieganu\u201d University of Medicine and Pharmacy, 400000 Cluj-Napoca, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela Adriana","family":"Iliescu","sequence":"additional","affiliation":[{"name":"Department of Physiology, \u201dCarol Davila\u201d University of Medicine and Pharmacy, 050474 Bucharest, Romania"},{"name":"Department of Ophtalmology, \u201dOcularcare\u201d Eye Clinic, 012244 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Cristina","family":"Ghi\u021b\u0103","sequence":"additional","affiliation":[{"name":"Department of Ophtalmology, \u201dOcularcare\u201d Eye Clinic, 012244 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brigitha","family":"Vlaicu","sequence":"additional","affiliation":[{"name":"Department of Hygiene, \u201dVictor Babes\u201d University of Medicine and Pharmacy, 300041 Timisoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mihai Aurelian","family":"Ghi\u021b\u0103","sequence":"additional","affiliation":[{"name":"Department of Physiology, \u201dCarol Davila\u201d University of Medicine and Pharmacy, 050474 Bucharest, Romania"},{"name":"Department of Ophtalmology, \u201dOcularcare\u201d Eye Clinic, 012244 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,2,14]]},"reference":[{"key":"ref_1","unstructured":"Chalam, K.V. (2011). Fundamentals and Principles of Ophthalmology: Section 2, 2011\u20132012, American Academy of Ophthalmology."},{"key":"ref_2","unstructured":"Kansky, J.J., and Bowling, B. (2011). Clinical Ophthalmology\u2014A Systemic Approach, Elsevier Saunders. [8th ed.]."},{"key":"ref_3","first-page":"4183","article-title":"Synthesis and physiological implications of melanic pigments","volume":"17","author":"Maranduca","year":"2019","journal-title":"Oncol. Lett."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"54","DOI":"10.4103\/2008-322X.180699","article-title":"Association of age related macular degeneration and age related hearing impairment","volume":"11","author":"Ghasemi","year":"2016","journal-title":"J. Ophthalmic Vis. 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Proc."}],"container-title":["Medicina"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1648-9144\/58\/2\/291\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T22:19:40Z","timestamp":1760134780000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1648-9144\/58\/2\/291"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,14]]},"references-count":12,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2022,2]]}},"alternative-id":["medicina58020291"],"URL":"https:\/\/doi.org\/10.3390\/medicina58020291","relation":{},"ISSN":["1648-9144"],"issn-type":[{"type":"electronic","value":"1648-9144"}],"subject":[],"published":{"date-parts":[[2022,2,14]]}}}