{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T14:00:13Z","timestamp":1787320813600,"version":"build-2736575974"},"reference-count":66,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2022,3,2]],"date-time":"2022-03-02T00:00:00Z","timestamp":1646179200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: Children with juvenile myasthenia gravis have a variety of symptoms, ranging from isolated intermittent ocular complaints to overall muscle weakness with or without respiratory insufficiency. This study aimed to investigate the efficacy of a specialized physical therapy with or without partial body weight supported treadmill training on pulmonary functional tests, neuromuscular functions, and quality of life. Materials and Methods: Thirty children, ranging in age from 13 to 16 years, were distributed randomly into two study groups (A or B). Both groups underwent a designed physical therapy program. In addition, group A underwent the partial body weight supported treadmill training. The treatment was conducted three times a week for 12 weeks successively. Pulmonary functional tests (FVC, FEV1, PEFR, and MVV), neuromuscular function tests (compound motor action potential, isometric muscle force of biceps brachii and rectus femoris, balance, walking endurance, and fatigue), and quality of life were measured before and after 12 successive weeks. Results: A significant improvement in all investigated variables were recorded in both groups in favor of group A. Conclusions: Both a specialized physical therapy and partial body weight supported treadmill training are effective in terms of enhancing pulmonary functional tests, neuromuscular functions, and quality of life. Partial body weight supported treadmill training is an excellent adjunctive to the physical therapy program.<\/jats:p>","DOI":"10.3390\/medicina58030374","type":"journal-article","created":{"date-parts":[[2022,3,2]],"date-time":"2022-03-02T22:53:25Z","timestamp":1646261605000},"page":"374","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Effect of Two Different Rehabilitation Approaches on Pulmonary Functional Tests, Neuromuscular Functions and Quality of Life in Juvenile Myasthenia Gravis: A Randomized Controlled Trial Study"],"prefix":"10.3390","volume":"58","author":[{"given":"Rasha A.","family":"Mohamed","sequence":"first","affiliation":[{"name":"Department of Physical Therapy for Growth and Developmental Disorders in Children and Its Surgery, Faculty of Physical Therapy, Cairo University, Cairo 12613, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"El Sayed H.","family":"Mohamed","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy, Cardiopulmonary Disorders, Buraydah Private Colleges, Buraydah 51418, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed A.","family":"Basiouny","sequence":"additional","affiliation":[{"name":"Department of Neurology and Neuropsychiatry, Faculty of Medicine, Tanta University, Tanta 31527, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibrahim M.","family":"Hamoda","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy for Neuromuscular Disorders and Its Surgery, Faculty of Physical Therapy, Kafr Al Sheikh University, Kafrelsheikh 33516, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"El Sayed M.","family":"Hanoura","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy for Internal Medicine, Faculty of Physical Therapy, Kafr Al Sheikh University, Kafrelsheikh 33516, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elbadawy I.","family":"Elhenedi","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy for Neuromuscular Disorders and Its Surgery, Faculty of Physical Therapy, Cairo University, Cairo 12613, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abd El Aziz A.","family":"Sherief","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy for Growth and Developmental Disorders in Children and Its Surgery, Faculty of Physical Therapy, Kafr Al Sheikh University, Kafrelsheikh 33516, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,3,2]]},"reference":[{"key":"ref_1","first-page":"1027","article-title":"Physiotherapy in myasthenia gravis","volume":"8","author":"Kwiatkowska","year":"2018","journal-title":"J. Phys. Educ. Sport"},{"key":"ref_2","first-page":"1","article-title":"Juvenile Myasthenia Gravis: A Short Review. Progress","volume":"2","author":"Mishra","year":"2018","journal-title":"Asp. Pediatr. Neonatol."},{"key":"ref_3","first-page":"404101","article-title":"Juvenile Myasthenia Gravis: A Paediatric Perspective","volume":"2011","author":"Finnis","year":"2011","journal-title":"Autoimmune Dis."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.nmd.2017.04.009","article-title":"Selective or predominant triceps muscle weakness in African\u2013American patients with myasthenia gravis","volume":"27","author":"Abraham","year":"2017","journal-title":"Neuromuscul. Disord."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1186\/1477-7525-8-129","article-title":"Quality of life and life circumstances in German myasthenia gravis patients","volume":"8","author":"Twork","year":"2010","journal-title":"Health Qual. Life Outcomes"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.nmd.2020.06.010","article-title":"Fatigue in patients with myasthenia gravis. A systematic review of the literature","volume":"30","author":"Ruiter","year":"2020","journal-title":"Neuromuscul. Disord."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1002\/mus.10378","article-title":"Maximal voluntary ventilation in myasthenia gravis","volume":"27","author":"Heliopoulos","year":"2003","journal-title":"Muscle Nerve"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1093\/qjmed\/hcn152","article-title":"Myasthenic crisis","volume":"102","author":"Chaudhuri","year":"2009","journal-title":"QJM"},{"key":"ref_9","first-page":"107","article-title":"Aging process","volume":"18","author":"Hess","year":"2006","journal-title":"Clin. Exp. Res."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1038\/ncpneuro0886","article-title":"A weak balance: The contribution of muscle weakness to postural instability and falls","volume":"4","author":"Horlings","year":"2008","journal-title":"Nat. Clin. Pract. Neurol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"189","DOI":"10.2165\/00007256-200636030-00001","article-title":"The Role of Core Stability in Athletic Function","volume":"36","author":"Press","year":"2006","journal-title":"Sports Med."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/17518423.2019.1683908","article-title":"Management of Muscle Spasticity in Children with Cerebral Palsy by Means of Extracorporeal Shockwave Therapy: A Systematic Review of the Literature","volume":"24","author":"Corrado","year":"2021","journal-title":"Dev. Neurorehabilit."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Corrado, B., Giardulli, B., and Costa, M. (2020). Evidence-Based Practice in Rehabilitation of Myasthenia Gravis. A Systematic Review of the Literature. J. Funct. Morphol. Kinesiol., 5.","DOI":"10.3390\/jfmk5040071"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Fonzo, M., Sirico, F., and Corrado, B. (2020). Evidence-Based Physical Therapy for Individuals with Rett Syndrome: A Systematic Review. Brain Sci., 10.","DOI":"10.3390\/brainsci10070410"},{"key":"ref_15","first-page":"656","article-title":"The chest and ageing: Radiological findings","volume":"38","author":"Hochhergger","year":"2012","journal-title":"J. Bras. Pneumol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.rmed.2018.09.001","article-title":"Effects of long-term respiratory muscle endurance training on respiratory and functional outcomes in patients with Myasthenia gravis","volume":"144","author":"Freitag","year":"2018","journal-title":"Respir. Med."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1016\/S0003-9993(23)00011-4","article-title":"Physical training effects in myasthenia gravis","volume":"74","author":"Lohi","year":"1993","journal-title":"Arch. Phys. Med. Rehabil."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1002\/mus.25552","article-title":"Exercise in myasthenia gravis: A feasibility study of aerobic and resistance training","volume":"56","author":"Rahbek","year":"2017","journal-title":"Muscle Nerve"},{"key":"ref_19","first-page":"49","article-title":"The kinematic and kinematic analysis of treadmill gait with various inclination and speed","volume":"5","author":"Yun","year":"2001","journal-title":"J Korean Soc. Aerobic Exerc."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1016\/j.clinbiomech.2009.07.004","article-title":"A comparison of gait biomechanics and metabolic requirements of overground and treadmill walking in people with stroke","volume":"24","author":"Brouwer","year":"2009","journal-title":"Clin. Biomech."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.pmrj.2013.08.604","article-title":"Effect of Partial Weight-Supported Treadmill Gait Training on Balance in Patients with Parkinson Disease","volume":"6","author":"Ganesan","year":"2014","journal-title":"PM&R"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1016\/j.apmr.2007.07.024","article-title":"Exercise Therapy and Other Types of Physical Therapy for Patients with Neuromuscular Diseases: A Systematic Review","volume":"88","author":"Cup","year":"2007","journal-title":"Arch. Phys. Med. Rehabil."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/j.gaitpost.2005.06.007","article-title":"Coordination of pelvis-HAT (head, arms and trunk) in anterior-posterior and medio-lateral directions during treadmill gait in preadolescents with\/without Down syndrome","volume":"23","author":"Kubo","year":"2006","journal-title":"Gait Posture"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1097\/NPT.0b013e31819800e2","article-title":"A Systematic Review of the Effectiveness of Treadmill Training and Body Weight Support in Pediatric Rehabilitation","volume":"33","author":"Damiano","year":"2009","journal-title":"J. Neurol. Phys. Ther."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1097\/PEP.0b013e3181bf53d9","article-title":"Effects of Intensive Locomotor Treadmill Training on Young Children with Cerebral Palsy","volume":"21","author":"Bellamy","year":"2009","journal-title":"Pediatr. Phys. Ther."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1111\/j.1469-8749.2008.03221.x","article-title":"Treadmill training with partial body-weight support in children with cerebral palsy: A systematic review","volume":"51","author":"Mutlu","year":"2009","journal-title":"Dev. Med. Child Neurol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.ijsu.2011.10.001","article-title":"CONSORT 2010 explanation and elaboration: Updated guidelines for reporting parallel group randomised trials","volume":"10","author":"Moher","year":"2012","journal-title":"Int. J. Surg."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"e7586","DOI":"10.1136\/bmj.e7586","article-title":"SPIRIT 2013 explanation and elaboration: Guidance for protocols of clinical trials","volume":"346","author":"Chan","year":"2013","journal-title":"BMJ"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1002\/mus.21195","article-title":"Juvenile myasthenia gravis","volume":"39","author":"Chiang","year":"2009","journal-title":"Muscle Nerve"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1212\/WNL.55.1.16","article-title":"Myasthenia gravis: Recommendations for clinical research standards","volume":"55","author":"Jaretzki","year":"2000","journal-title":"Neurology"},{"key":"ref_31","unstructured":"Mottram, C.D. (2017). Ruppel\u2019s Manual of Pulmonary Function Testing, Mosby. [11th ed.]."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1097\/WNP.0000000000000252","article-title":"Compound motor action potential: Electrophysiological marker for muscle training","volume":"33","author":"Molin","year":"2016","journal-title":"J. Clin. Neurophysiol."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Blum, A.S., and Rutkove, S.B. (2007). Pediatric Nerve conduction studies and EMG. The Clinical Neurophysiology Primer, Humana Press Inc.","DOI":"10.1007\/978-1-59745-271-7"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1002\/mus.21641","article-title":"Electrophysiological characteristics of motor units and muscle fibers in trained and untrained young male subjects","volume":"42","author":"Duez","year":"2010","journal-title":"Muscle Nerve"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1016\/j.nmd.2007.08.003","article-title":"Reliability and feasibility of the six minute walk test in subjects with myotonic dystrophy","volume":"17","author":"Kierkegaard","year":"2007","journal-title":"Neuromuscul. Disord."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1093\/ptj\/82.2.128","article-title":"Age- and Gender-Related Test Performance in Community-Dwelling Elderly People: Six-Minute Walk Test, Berg Balance Scale, Timed Up & Go Test, and Gait Speeds","volume":"82","author":"Steffen","year":"2002","journal-title":"Phys. Ther."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"American Thoracic Society (2002). ATS statement: Guidelines for the six-minute walk test. Am. J. Respir. Crit. Care Med., 166, 111\u2013117.","DOI":"10.1164\/ajrccm.166.1.at1102"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/1477-7525-5-43","article-title":"Impaired health-related quality of life in children and adolescents with chronic conditions: A comparative analysis of 10 disease clusters and 33 disease categories\/severities utilizing the PedsQL 4.0 Generic Core Scales","volume":"5","author":"Varni","year":"2007","journal-title":"Health Qual. Life Outcomes"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"e1015","DOI":"10.1542\/peds.2014-2440","article-title":"Fatigue in Child Chronic Health Conditions: A Systematic Review of Assessment Instruments","volume":"135","author":"Crichton","year":"2015","journal-title":"Pediatrics"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1164\/rccm.200503-322OC","article-title":"Quality of Life, Physical Disability, and Respiratory Impairment in Duchenne Muscular Dystrophy","volume":"172","author":"Kohler","year":"2005","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"g1687","DOI":"10.1136\/bmj.g1687","article-title":"Better reporting of interventions: Template for intervention description and replication (TIDieR) checklist and guide","volume":"348","author":"Hoffmann","year":"2014","journal-title":"BMJ"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1111\/j.1600-0404.2010.01369.x","article-title":"Airway limitation and exercise intolerance in well-regulated myasthenia gravis patients","volume":"190","author":"Elsais","year":"2010","journal-title":"Acta Neurol. Scand. Suppl."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"S108","DOI":"10.1097\/00002060-200211001-00012","article-title":"Physical Activity, Health Impairments, and Disability in Neuromuscular Disease","volume":"81","author":"McDonald","year":"2002","journal-title":"Am. J. Phys. Med. Rehabil."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1080\/09638288.2016.1191552","article-title":"Exploring quality of life in people with slowly-progressive neuromuscular disease","volume":"39","author":"Dany","year":"2017","journal-title":"Disabil. Rehabil."},{"key":"ref_45","unstructured":"LeMura, L., and Von Duvillard, S.P. (2004). Clinical Exercise Physiology: Application and Physiological Principles, Lippincott Williams & Wilkins. [1st ed.]."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.autrev.2017.11.010","article-title":"Physical activity and autoimmune diseases: Get moving and manage the disease","volume":"17","author":"Sharif","year":"2018","journal-title":"Autoimmun. Rev."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"308","DOI":"10.3109\/17518423.2012.731085","article-title":"Functional strength training in child with cerebral palsy GMFCS IV: Case report","volume":"16","author":"Golineleo","year":"2013","journal-title":"Dev. Neurorehabilit."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1097\/00131402-200309000-00004","article-title":"Exercise in Neuromuscular Disease","volume":"5","author":"Krivickas","year":"2003","journal-title":"J. Clin. Neuromuscul. Dis."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1002\/mus.25493","article-title":"Physical exercise in myasthenia gravis is safe and improves neuromuscular parameters and physical performance-based measures: A pilot study","volume":"56","author":"Westerberg","year":"2017","journal-title":"Muscle Nerve"},{"key":"ref_50","first-page":"CD002840","article-title":"Treadmill training and body weight support for walking after stroke","volume":"1","author":"Mehrholz","year":"2014","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1007\/s00421-007-0481-0","article-title":"Influence of muscle architecture on the torque and power\u2013velocity characteristics of young and elderly men","volume":"100","author":"Thom","year":"2007","journal-title":"Eur. J. Appl. Physiol."},{"key":"ref_52","first-page":"1","article-title":"Respiratory muscle training improves functional outcomes and reduces fatigue in patients with myasthenia gravis: A single center hospital-based prospective stud","volume":"5","author":"Hsu","year":"2020","journal-title":"BioMed Res. Int."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/s10741-007-9055-9","article-title":"Resistance exercise: Training adaptations and developing a safe exercise prescription","volume":"13","author":"Braith","year":"2008","journal-title":"Hear. Fail. Rev."},{"key":"ref_54","first-page":"CD006986","article-title":"Acetylcholinesterase inhibitor treatment for myasthenia gravis","volume":"10","author":"Mehndiratta","year":"2014","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"2665","DOI":"10.1519\/JSC.0000000000002730","article-title":"Recent Advancements in Our Understanding of the Ergogenic Effect of Respiratory Muscle Training in Healthy Humans: A Systematic Review","volume":"32","author":"Shei","year":"2018","journal-title":"J. Strength Cond. Res."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1590\/S1413-35552012005000131","article-title":"Effect of upper extremity proprioceptive neuromuscular facilitation combined with elastic resistance bands on respiratory muscle strength: A randomized controlled trial","volume":"17","author":"Areas","year":"2013","journal-title":"Braz. J. Phys. Ther."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.resp.2014.05.002","article-title":"The effects of respiratory muscle training on respiratory mechanics and energy cost","volume":"200","author":"Held","year":"2014","journal-title":"Respir. Physiol. Neurobiol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S1579-2129(06)70099-4","article-title":"Pursed lips breathing","volume":"40","author":"Fregonezi","year":"2004","journal-title":"Arch. Bronconeumol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1589\/jpts.29.1454","article-title":"Effects of high intensity aerobic exercise on treadmill on maximum-expiratory lung capacity of elderly women","volume":"29","author":"Park","year":"2017","journal-title":"J. Phys. Ther. Sci."},{"key":"ref_60","first-page":"41","article-title":"Effect of treadmill-walking training with deep breathing exercises on pulmonary functions in patients with Parkinson\u2019s disease","volume":"9","author":"Elnozhe","year":"2019","journal-title":"J. Adv. Pharm. Edu. Res."},{"key":"ref_61","unstructured":"Korean Academy of Cardiorespiratory Physical Therapy (2014). Cardiovascular and Pulmonary: Physical Therapy Intervention, Panmun Education Publication Company."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"e11510","DOI":"10.1097\/MD.0000000000011510","article-title":"The impact of physical exercise on neuromuscular function in Myasthenia gravis patients: A single-subject design study","volume":"97","author":"Westerberg","year":"2018","journal-title":"Medicine"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1002\/mus.24054","article-title":"Effects of balance strategy training in myasthenia gravis: A case study series","volume":"49","author":"Wong","year":"2014","journal-title":"Muscle Nerve"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"448","DOI":"10.7861\/clinmedicine.9-5-448","article-title":"Breathlessness, fatigue and the respiratory muscles","volume":"9","author":"Mioxham","year":"2009","journal-title":"Clin. Med."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"2312","DOI":"10.1007\/s00415-018-8995-4","article-title":"Fatigue in patients with myasthenia gravis","volume":"265","author":"Alekseeva","year":"2018","journal-title":"J. Neurol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1097\/01.PEP.0000127569.83372.C8","article-title":"Locomotor Training with Partial Body Weight Support on a Treadmill in a Nonambulatory Child with Spastic Tetraplegic Cerebral Palsy: A Case Report","volume":"16","author":"Day","year":"2004","journal-title":"Pediatr. Phys. Ther."}],"container-title":["Medicina"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1648-9144\/58\/3\/374\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T22:30:45Z","timestamp":1760135445000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1648-9144\/58\/3\/374"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,2]]},"references-count":66,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2022,3]]}},"alternative-id":["medicina58030374"],"URL":"https:\/\/doi.org\/10.3390\/medicina58030374","relation":{},"ISSN":["1648-9144"],"issn-type":[{"value":"1648-9144","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,2]]}}}