{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T13:52:35Z","timestamp":1789480355380,"version":"build-2803163510"},"reference-count":11,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2022,3,10]],"date-time":"2022-03-10T00:00:00Z","timestamp":1646870400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>A 60-year-old woman was diagnosed with nonfunctional pancreatic neuroendocrine neoplasm with multiple liver metastases and was administered everolimus. Due to persistent epigastric pain and diarrhea, a colonoscopy was performed on the 14th day after the start of everolimus administration, which revealed small bleeding ulcers in the ileocecal region, transverse colon, and rectum. These adverse effects were attributed to the everolimus; it was immediately discontinued, and the patient\u2019s clinical symptoms and imaging findings improved. We concurred that the administration of calcium channel blockers resulted in the inhibition of everolimus metabolism and the disease onset. The everolimus was discontinued. There was no subsequent recurrence of hemorrhagic colitis.<\/jats:p>","DOI":"10.3390\/medicina58030410","type":"journal-article","created":{"date-parts":[[2022,3,10]],"date-time":"2022-03-10T20:19:10Z","timestamp":1646943550000},"page":"410","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Hemorrhagic Colitis Caused by Everolimus in a Patient with Nonfunctional Pancreatic Neuroendocrine Neoplasms: A Case Report"],"prefix":"10.3390","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9521-0451","authenticated-orcid":false,"given":"Noriyuki","family":"Arakawa","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Takeda General Hospital, Aizuwakamatsu 965-8585, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2271-2717","authenticated-orcid":false,"given":"Atsushi","family":"Irisawa","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Dokkyo Medical University, Mibu 321-0293, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2804-4588","authenticated-orcid":false,"given":"Kazuyuki","family":"Ishida","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology, Dokkyo Medical University, Mibu 321-0293, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuya","family":"Tsunoda","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Takeda General Hospital, Aizuwakamatsu 965-8585, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiko","family":"Yamaguchi","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology, Takeda General Hospital, Aizuwakamatsu 965-8585, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akane","family":"Yamabe","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Dokkyo Medical University, Mibu 321-0293, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Eizuka","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Gastroenterology, Iwate Medical University, Morioka 020-0023, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunzo","family":"Tokioka","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Takeda General Hospital, Aizuwakamatsu 965-8585, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroto","family":"Wakabayashi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Takeda General Hospital, Aizuwakamatsu 965-8585, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,3,10]]},"reference":[{"key":"ref_1","unstructured":"Japan Neuroendocrine Tumor Society (2019). Pancreatic and Gastrointestinal Neuroendocrine Neoplasm (NEN) Clinical Guidelines, Kanehara & Co., Ltd.. [2nd ed.]."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Krug, S., Damm, M., Garbe, J., K\u00f6nig, S., Schmitz, R.L., Michl, P., Schrader, J., and Rinke, A. (2021). Finding the Appropriate Therapeutic Strategy in Patients with Neuroendocrine Tumors of the Pancreas: Guideline Recommendations Meet the Clinical Reality. J Clin. 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Oncol."},{"key":"ref_6","first-page":"1131","article-title":"Long-term outcomes and prognostic factors in 78 Japanese patients with advanced pancreatic neuroendocrine neoplasms: A single-center retrospective study","volume":"45","author":"Lee","year":"2015","journal-title":"Jpn. J. Clin. Oncol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1016\/S0140-6736(15)00817-X","article-title":"Everolimus for the treatment of advanced, nonfunctional neuroendocrine tumours of the lung or gastrointestinal tract (RADIANT-4): A randomised, placebo-controlled, phase 3 study","volume":"387","author":"Yao","year":"2016","journal-title":"Lancet"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1007\/s12328-019-00978-8","article-title":"Severe gastrointestinal hemorrhage related to everolimus: A case report","volume":"12","author":"Tsunematsu","year":"2019","journal-title":"Clin. J. 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