{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T02:59:38Z","timestamp":1760151578231,"version":"build-2065373602"},"reference-count":52,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2022,3,21]],"date-time":"2022-03-21T00:00:00Z","timestamp":1647820800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"NIH CORE Grant P30 EY08098 to the Department of Ophthalmology, the Eye and Ear Foundation of Pittsburgh, and from an unrestricted grant from Research to Prevent Blindness, New York, NY.","award":["P30 EY08098"],"award-info":[{"award-number":["P30 EY08098"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: Secondary ocular localizations of hematological malignancies are blinding conditions with a poor prognosis, and often result in a delay in the diagnosis. Materials and Methods: We describe a series of rare cases of ocular involvement in six patients with hematological malignancies, reportedly in remission, who presented secondary ocular localizations, challenging to diagnose. Two patients had an acute lymphoblastic leukemia (ALL) and developed either a posterior scleritis or a pseudo-panuveitis with ciliary process infiltration. One patient had iris plasmacytoma and developed an anterior uveitis as a secondary presentation. Two patients had a current systemic diffuse large B-cell lymphoma (DLBCL) and were referred either for intermediate uveitis or for papilledema and vitritis with secondary retinitis. Finally, one patient with an acute myeloid leukemia (AML) presented a conjunctival localization of a myeloid sarcoma. We herein summarize the current knowledge of ophthalmologic manifestations of extramedullary hematopathies. Results: Inflammatory signs were associated with symptomatic infiltrative lesions well displayed in either the iris, the retina, the choroid, or the cavernous sinus, from the admission of the patients in the ophthalmological department. These findings suggest that patients with ALL, AML, systemic DLBCL, and myeloma can present with ophthalmic involvement, even after having been reported as in remission following an effective systemic treatment and\/or allograft. Conclusions: Early detection of hidden recurrence in the eyes may permit effective treatment. Furthermore, oncologists and ophthalmologists should be aware of those rare ocular malignant locations when monitoring patient\u2019s progression after initial treatment, and close ophthalmologic examinations should be recommended when detecting patient\u2019s ocular symptoms after treatment.<\/jats:p>","DOI":"10.3390\/medicina58030456","type":"journal-article","created":{"date-parts":[[2022,3,21]],"date-time":"2022-03-21T21:48:42Z","timestamp":1647899322000},"page":"456","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Hidden in the Eyes\u2014Recurrence of Systemic Hemopathies Reportedly \u201cIn Remission\u201d: Six Cases and Review of Literature"],"prefix":"10.3390","volume":"58","author":[{"given":"Margot","family":"Denier","sequence":"first","affiliation":[{"name":"Centre Hospitalier National des Quinze-Vingts, CIC 1423, DHU Sight Restore, 28 rue de Charenton, Sorbonne-Universit\u00e9s, Universit\u00e9 Pierre et Marie Curie (UPMC), 75012 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Tick","sequence":"additional","affiliation":[{"name":"Centre Hospitalier National des Quinze-Vingts, CIC 1423, DHU Sight Restore, 28 rue de Charenton, Sorbonne-Universit\u00e9s, Universit\u00e9 Pierre et Marie Curie (UPMC), 75012 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Romain","family":"Dubois","sequence":"additional","affiliation":[{"name":"Institut de Pathologie, CHRU de Lille, 59000 Lille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Remy","family":"Dulery","sequence":"additional","affiliation":[{"name":"Service d\u2019H\u00e9matologie Clinique et de Th\u00e9rapie Cellulaire, H\u00f4pital Saint Antoine, AP-HP, Sorbonne Universit\u00e9, INSERM UMRs938, 75012 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew W.","family":"Eller","sequence":"additional","affiliation":[{"name":"Ophthalmology Service, University of Pittsburgh School of Medicine, Pittsburgh, PA 75012, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felipe","family":"Suarez","sequence":"additional","affiliation":[{"name":"Department of Hematology, H\u00f4pital Necker-Enfants Malades, INSERM UMR 1163 et CNRS ERL 8254, Institut Imagine, Sorbonne Paris Cit\u00e9, Universit\u00e9 Paris Descartes, 149 rue de S\u00e8vres, CEDEX 15, 75743 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Burroni","sequence":"additional","affiliation":[{"name":"Centre de Recherche des Cordeliers, Sorbonne Universit\u00e9, Inserm, Universit\u00e9 de Paris, 75006 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claude-Alain","family":"Maurage","sequence":"additional","affiliation":[{"name":"Centre de Recherche Jean-Pierre Aubert INSERM: U837, Universit\u00e9 du Droit et de la Sant\u00e9\u2014Lille II, Facult\u00e9 de M\u00e9decine 1, Place de Verdun, CEDEX, 59045 Lille, France"},{"name":"Institut de Pathologie\u2014CHRU de Lille, 59000 Lille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claire","family":"Bories","sequence":"additional","affiliation":[{"name":"France Department of Hematology, CHRU, 59000 Lille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johanna","family":"Konopacki","sequence":"additional","affiliation":[{"name":"Department of Hematology, H\u00f4pital D\u2019instruction des Arm\u00e9es Percy, 92140 Clamart, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel","family":"Puech","sequence":"additional","affiliation":[{"name":"Centre Explore Vision, 75001 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Didier","family":"Bouscary","sequence":"additional","affiliation":[{"name":"Department of Hematology, Facult\u00e9 de M\u00e9decine Sorbonne Paris Cit\u00e9, Universit\u00e9 Paris Descartes, H\u00f4pital Cochin, AP-HP, 75014 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberte","family":"Cantalloube","sequence":"additional","affiliation":[{"name":"Centre Hospitalier National des Quinze-Vingts, CIC 1423, DHU Sight Restore, 28 rue de Charenton, Sorbonne-Universit\u00e9s, Universit\u00e9 Pierre et Marie Curie (UPMC), 75012 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emmanuel","family":"H\u00e9ron","sequence":"additional","affiliation":[{"name":"Centre Hospitalier National des Quinze-Vingts, CIC 1423, DHU Sight Restore, 28 rue de Charenton, Sorbonne-Universit\u00e9s, Universit\u00e9 Pierre et Marie Curie (UPMC), 75012 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ambroise","family":"Mar\u00e7ais","sequence":"additional","affiliation":[{"name":"Department of Hematology, H\u00f4pital Necker-Enfants Malades, INSERM UMR 1163 et CNRS ERL 8254, Institut Imagine, Sorbonne Paris Cit\u00e9, Universit\u00e9 Paris Descartes, 149 rue de S\u00e8vres, CEDEX 15, 75743 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christophe","family":"Habas","sequence":"additional","affiliation":[{"name":"Centre Hospitalier National des Quinze-Vingts, CIC 1423, DHU Sight Restore, 28 rue de Charenton, Sorbonne-Universit\u00e9s, Universit\u00e9 Pierre et Marie Curie (UPMC), 75012 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincent","family":"Theillac","sequence":"additional","affiliation":[{"name":"Centre Hospitalier National des Quinze-Vingts, CIC 1423, DHU Sight Restore, 28 rue de Charenton, Sorbonne-Universit\u00e9s, Universit\u00e9 Pierre et Marie Curie (UPMC), 75012 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chafik","family":"Keilani","sequence":"additional","affiliation":[{"name":"Centre Hospitalier National des Quinze-Vingts, CIC 1423, DHU Sight Restore, 28 rue de Charenton, Sorbonne-Universit\u00e9s, Universit\u00e9 Pierre et Marie Curie (UPMC), 75012 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabrielle R.","family":"Bonhomme","sequence":"additional","affiliation":[{"name":"Ophthalmology Service, University of Pittsburgh School of Medicine, Pittsburgh, PA 75012, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denise S.","family":"Gallagher","sequence":"additional","affiliation":[{"name":"Ophthalmology Service, University of Pittsburgh School of Medicine, Pittsburgh, PA 75012, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julien","family":"Boumendil","sequence":"additional","affiliation":[{"name":"Centre Hospitalier National des Quinze-Vingts, CIC 1423, DHU Sight Restore, 28 rue de Charenton, Sorbonne-Universit\u00e9s, Universit\u00e9 Pierre et Marie Curie (UPMC), 75012 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wajed","family":"Abarah","sequence":"additional","affiliation":[{"name":"Department of Hematology, H\u00f4pital de Meaux, 77100 Meaux, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neila","family":"Sedira","sequence":"additional","affiliation":[{"name":"Centre Hospitalier National des Quinze-Vingts, CIC 1423, DHU Sight Restore, 28 rue de Charenton, Sorbonne-Universit\u00e9s, Universit\u00e9 Pierre et Marie Curie (UPMC), 75012 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"St\u00e9phane","family":"Bertin","sequence":"additional","affiliation":[{"name":"Centre Hospitalier National des Quinze-Vingts, CIC 1423, DHU Sight Restore, 28 rue de Charenton, Sorbonne-Universit\u00e9s, Universit\u00e9 Pierre et Marie Curie (UPMC), 75012 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7791-0470","authenticated-orcid":false,"given":"Sylvain","family":"Choquet","sequence":"additional","affiliation":[{"name":"Department of Hematology, H\u00f4pital Piti\u00e9-Salp\u00eatri\u00e8re, 75013 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9-Alain","family":"Sahel","sequence":"additional","affiliation":[{"name":"Centre Hospitalier National des Quinze-Vingts, CIC 1423, DHU Sight Restore, 28 rue de Charenton, Sorbonne-Universit\u00e9s, Universit\u00e9 Pierre et Marie Curie (UPMC), 75012 Paris, France"},{"name":"Ophthalmology Service, University of Pittsburgh School of Medicine, Pittsburgh, PA 75012, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lilia","family":"Merabet","sequence":"additional","affiliation":[{"name":"Centre Hospitalier National des Quinze-Vingts, CIC 1423, DHU Sight Restore, 28 rue de Charenton, Sorbonne-Universit\u00e9s, Universit\u00e9 Pierre et Marie Curie (UPMC), 75012 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fran\u00e7oise","family":"Brignole-Baudouin","sequence":"additional","affiliation":[{"name":"Centre Hospitalier National des Quinze-Vingts, CIC 1423, DHU Sight Restore, 28 rue de Charenton, Sorbonne-Universit\u00e9s, Universit\u00e9 Pierre et Marie Curie (UPMC), 75012 Paris, France"},{"name":"Sorbonne Universit\u00e9s, 75006 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"Putterman","sequence":"additional","affiliation":[{"name":"Centre Hospitalier National des Quinze-Vingts, CIC 1423, DHU Sight Restore, 28 rue de Charenton, Sorbonne-Universit\u00e9s, Universit\u00e9 Pierre et Marie Curie (UPMC), 75012 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie-H\u00e9l\u00e8ne","family":"Errera","sequence":"additional","affiliation":[{"name":"Centre Hospitalier National des Quinze-Vingts, CIC 1423, DHU Sight Restore, 28 rue de Charenton, Sorbonne-Universit\u00e9s, Universit\u00e9 Pierre et Marie Curie (UPMC), 75012 Paris, France"},{"name":"Ophthalmology Service, University of Pittsburgh School of Medicine, Pittsburgh, PA 75012, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,3,21]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization (2017). 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