{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T14:30:21Z","timestamp":1789655421409,"version":"4.0.1"},"reference-count":28,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2022,3,26]],"date-time":"2022-03-26T00:00:00Z","timestamp":1648252800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the Research Council of Lithuania","award":["LIG01\/2011"],"award-info":[{"award-number":["LIG01\/2011"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and objectives: Improving early diagnosis and advances in colorectal cancer (CRC) treatment leads to longer survival of these patients. The purpose of this study was to identify the main surgical factors affecting long-term Quality of life (QoL) among colorectal cancer patients after surgery. Materials and Methods: QoL was prospectively evaluated in patients undergoing elective colorectal cancer resection operations in three CRC surgery centers of Lithuania using EORTC generic (QLQC-30) and disease-specific (QLQ-CR29) questionnaires at the time of preoperative admission and 1, 24, and 72 months after surgery. QoL was evaluated among different patient groups, diagnostic and treatment modalities, disease, and postoperative complications. Non-parametric tests and multivariate logistic regression models were used for statistical analysis. Results: Eighty-eight consecutive CRC patients from three institutions were included in the study over a three-month inclusion period, 42 (47.73%) women and 46 (52.27%) men, mean age 64.2 \u00b1 11.5 years. Most tumors were localized in the sigmoid colon and rectum. The largest number of patients had stage III cancer. Twenty-nine patients died\u2014a 6-year survival rate was 67%. 50 of 59 live patients (84.8%) responded to the questionnaire 6 years after their operation. Evaluating changes in quality of life 72 months after surgery with assessments before surgery, both questionnaire responses revealed good long-term CRC surgical treatment results: improved general and functional scale estimates and decreased symptom scale ratings. The multivariate analysis found that age, stoma formation, and rectal cancer were independent risk factors for having worse QoL six years after surgical intervention. Conclusions: Six years after surgery, QoL returns to preoperative levels. Age, stoma formation, adjuvant treatment, and rectal cancer reduce long-term QoL.<\/jats:p>","DOI":"10.3390\/medicina58040482","type":"journal-article","created":{"date-parts":[[2022,3,27]],"date-time":"2022-03-27T21:29:36Z","timestamp":1648416576000},"page":"482","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Predictors of Quality of Life Six Years after Curative Colorectal Cancer Surgery: Results of the Prospective Multicenter Study"],"prefix":"10.3390","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2296-5191","authenticated-orcid":false,"given":"Gintare","family":"Valeikaite-Tauginiene","sequence":"first","affiliation":[{"name":"Clinic of Gastroenterology, Nephrourology, and Surgery, Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Santariskiu Str. 2, 08661 Vilnius, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agne","family":"Kraujelyte","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Vilnius University, Ciurlionio Str. 21, 03101 Vilnius, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eligijus","family":"Poskus","sequence":"additional","affiliation":[{"name":"Clinic of Gastroenterology, Nephrourology, and Surgery, Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Santariskiu Str. 2, 08661 Vilnius, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valdemaras","family":"Jotautas","sequence":"additional","affiliation":[{"name":"Clinic of Gastroenterology, Nephrourology, and Surgery, Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Santariskiu Str. 2, 08661 Vilnius, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zilvinas","family":"Saladzinskas","sequence":"additional","affiliation":[{"name":"Clinic of Surgery, Lithuanian University of Health Sciences, Eiveniu Str. 2, 50009 Kaunas, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Algimantas","family":"Tamelis","sequence":"additional","affiliation":[{"name":"Clinic of Surgery, Lithuanian University of Health Sciences, Eiveniu Str. 2, 50009 Kaunas, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulius","family":"Lizdenis","sequence":"additional","affiliation":[{"name":"Clinic of Surgery, Lithuanian University of Health Sciences, Eiveniu Str. 2, 50009 Kaunas, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audrius","family":"Dulskas","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Vilnius University, Ciurlionio Str. 21, 03101 Vilnius, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narimantas Evaldas","family":"Samalavicius","sequence":"additional","affiliation":[{"name":"Clinic of Internal, Family Medicine and Oncology, Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Santariskiu Str. 2, 08661 Vilnius, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K\u0119stutis","family":"Strupas","sequence":"additional","affiliation":[{"name":"Clinic of Gastroenterology, Nephrourology, and Surgery, Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Santariskiu Str. 2, 08661 Vilnius, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6931-6041","authenticated-orcid":false,"given":"Tomas","family":"Po\u0161kus","sequence":"additional","affiliation":[{"name":"Clinic of Gastroenterology, Nephrourology, and Surgery, Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Santariskiu Str. 2, 08661 Vilnius, Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,3,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"433","DOI":"10.3892\/ol.2015.3171","article-title":"National burden of colorectal cancer in Lithuania and country\u2019s ranking across 45 European nations","volume":"10","author":"Lunevicius","year":"2015","journal-title":"Oncol. Lett."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"394","DOI":"10.3322\/caac.21492","article-title":"Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"68","author":"Bray","year":"2018","journal-title":"CA Cancer J. Clin."},{"key":"ref_3","unstructured":"Ferlay, J. (2021). Cancer Incidence in Five Continents, CI5plus: IARC CancerBase. No 9, International Agency for Research on Cancer. Available online: http:\/\/ci5.iarc.fr."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3322\/caac.21590","article-title":"Cancer statistics, 2020","volume":"70","author":"Siegel","year":"2020","journal-title":"CA Cancer J. Clin."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1097\/CEJ.0000000000000096","article-title":"Initial results of the National Colorectal Cancer Screening Program in Lithuania","volume":"24","author":"Poskus","year":"2015","journal-title":"Eur. J. Cancer Prev."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1007\/s00384-018-3021-y","article-title":"Improved perioperative care is associated with improved long-term survival in colorectal cancer","volume":"33","author":"Poskus","year":"2018","journal-title":"Int. J. Color. Dis."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Dulskas, A., Gaizauskas, V., Kildusiene, I., Samalavicius, N.E., and Smailyte, G. (2020). Improvement of Survival over Time for Colorectal Cancer Patients: A Population-Based Study. J. Clin. Med., 9.","DOI":"10.3390\/jcm9124038"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"327","DOI":"10.3109\/07357909309024860","article-title":"Quality of Life in Cancer: Definition, Purpose, and Method of Measurement","volume":"11","author":"Cella","year":"1993","journal-title":"Cancer Investig."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1200\/JCO.2007.13.3439","article-title":"The prognostic significance of patient-reported outcomes in cancer clinical trials","volume":"26","author":"Gotay","year":"2008","journal-title":"J. Clin. Oncol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/S1470-2045(09)70200-1","article-title":"Baseline quality of life as a prognostic indicator of survival: A meta-analysis of individual patient data from EORTC clinical trials","volume":"10","author":"Quinten","year":"2009","journal-title":"Lancet Oncol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1007\/s11136-016-1381-8","article-title":"Predictors of health-related quality of life and association with survival may identify colorectal cancer patients at high risk of poor prognosis","volume":"26","author":"Reyes","year":"2016","journal-title":"Qual. Life Res."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1080\/02841860600847053","article-title":"Prospective analysis of quality of life in the first year after colo-rectal cancer surgery","volume":"46","author":"Tsunoda","year":"2007","journal-title":"Acta Oncol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"4829","DOI":"10.1200\/JCO.2004.02.018","article-title":"Quality of Life in Patients with Colorectal Cancer 1 Year After Diagnosis Compared with the General Population: A Population-Based Study","volume":"22","author":"Arndt","year":"2004","journal-title":"J. Clin. Oncol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.medici.2015.01.006","article-title":"Short-term results of quality of life for curatively treated colorectal cancer patients in Lithuania","volume":"51","author":"Lizdenis","year":"2015","journal-title":"Medicina"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1848","DOI":"10.1016\/j.ejca.2006.01.059","article-title":"Restrictions in quality of life in colorectal cancer patients over three years after diagnosis: A population based study","volume":"42","author":"Arndt","year":"2006","journal-title":"Eur. J. Cancer"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1846","DOI":"10.1245\/s10434-008-9923-0","article-title":"Health-Related Quality of Life Outcomes in Disease-Free Survivors of Mid-Low Rectal Cancer After Curative Surgery","volume":"15","author":"Pucciarelli","year":"2008","journal-title":"Ann. Surg. Oncol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1007\/DCR.0b013e3181bdc408","article-title":"Early and Late Complications Among Long-Term Colorectal Cancer Survivors with Ostomy or Anastomosis","volume":"53","author":"Liu","year":"2010","journal-title":"Dis. Colon Rectum"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"2422","DOI":"10.1245\/s10434-011-1650-2","article-title":"Long-Term Follow-Up and Individual Item Analysis of Quality of Life Assessments Related to Laparoscopic-Assisted Colectomy in the COST Trial 93-46-53 (INT 0146)","volume":"18","author":"Stucky","year":"2011","journal-title":"Ann. Surg. Oncol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1002\/bjs.9144","article-title":"Health-related quality of life after laparoscopic and open surgery for rectal cancer in a randomized trial","volume":"100","author":"Andersson","year":"2013","journal-title":"Br. J. Surg."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1186\/s12957-020-01968-8","article-title":"Risk factors for anastomotic leakage and its impact on long-term survival in left-sided colorectal cancer surgery","volume":"18","author":"Kryzauskas","year":"2020","journal-title":"World J. Surg. Oncol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"2911","DOI":"10.1007\/s00464-013-2854-2","article-title":"Minimally invasive surgery for colorectal cancer: Quality of life and satisfaction with care in elderly patients","volume":"27","author":"Scarpa","year":"2013","journal-title":"Surg. Endosc."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s10151-012-0869-7","article-title":"Prospective evaluation of health-related quality of life after laparoscopic colectomy for cancer","volume":"17","author":"Theodoropoulos","year":"2012","journal-title":"Tech. Coloproctol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1007\/s11136-011-0067-5","article-title":"A five-year prospective study of quality of life after colorectal cancer","volume":"21","author":"Chambers","year":"2011","journal-title":"Qual. Life Res."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/s10552-013-0313-y","article-title":"Lifestyle factors and health-related quality of life in colorectal cancer survivors","volume":"25","author":"Schlesinger","year":"2013","journal-title":"Cancer Causes Control"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1590\/s0004-2803.202000000-32","article-title":"Survival of patients with colorectal can-cer in a cancer center","volume":"57","author":"Oliveira","year":"2020","journal-title":"Arq. Gastroenterol."},{"key":"ref_26","first-page":"41","article-title":"Evaluation of prognostic factors for 5 year-survival after surgery for colorectal cancer","volume":"91","author":"Micu","year":"2020","journal-title":"Ann. Ital. Chir."},{"key":"ref_27","first-page":"519","article-title":"The Risk Factors Affecting Survival in Colorectal Cancer in Taiwan","volume":"47","author":"Lee","year":"2018","journal-title":"Iran. J. Public Health"},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Weixler, B., Warschkow, R., Ramser, M., Droeser, R., Von Holzen, U., Oertli, D., and Kettelhack, C. (2016). Urgent surgery after emergency presentation for colorectal cancer has no impact on overall and disease-free survival: A propensity score analysis. 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