{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T11:46:40Z","timestamp":1769168800552,"version":"3.49.0"},"reference-count":30,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2022,3,30]],"date-time":"2022-03-30T00:00:00Z","timestamp":1648598400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: This study aimed to investigate the process and morphology of thoracic and lumbosacral bone fusion in patients with adult spinal deformity (ASD) who underwent circumferential minimally invasive spine surgery (CMIS) by lateral lumbar interbody fusion (LLIF) and percutaneous pedicle screws (PPSs) without bone grafting in the thoracic spine and who have risk factors for bone fusion failure in the thoracic spine. Materials and Methods: This retrospective study included 61 patients with spinal deformities (46 women and 15 men) who underwent CMIS with LLIF and PPSs at our hospital after 2016 and completed a 3-year postoperative follow-up. The rate and morphology of bone fusion and rod fracture rate in the thoracic and lumbosacral vertebrae were evaluated. Patients were divided into the thoracic spine spontaneous bone fusion group and the bone fusion failure group. The data of various spinopelvic parameters and the incidence of complications were compared. The vertebral body conditions in the thoracic spine were classified as less degenerative (type N), osteophyte (type O), and diffuse idiopathic skeletal hyperostosis (DISH) (type D). Results: After three postoperative years, the bone fusion rates were 54%, 95%, and 89% for the thoracic, lumbar, and lumbosacral spine, respectively. Screw loosening in the thoracic vertebrae was significantly higher in the bone fusion failure group, while no significant differences were observed in the spinopelvic parameters, Oswestry Disability Index (ODI), and rate of proximal junctional kyphosis and rod fractures. Type N vertebral body condition and screw loosening were identified as risk factors for spontaneous bone fusion failure in the thoracic spine. Conclusion: This study indicated that spontaneous bone fusion is likely to be obtained without screw loosening, and even if bone fusion is not obtained, there is no effect on clinical results with the mid-term (3-year) results of CMIS without bone grafting in the thoracic spine.<\/jats:p>","DOI":"10.3390\/medicina58040496","type":"journal-article","created":{"date-parts":[[2022,3,30]],"date-time":"2022-03-30T21:28:39Z","timestamp":1648675719000},"page":"496","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Bone Fusion Morphology after Circumferential Minimally Invasive Spine Surgery Using Lateral Lumbar Interbody Fusion and Percutaneous Pedicle Screws without Bone Grafting in the Thoracic Spine: A Retrospective Study"],"prefix":"10.3390","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6062-6767","authenticated-orcid":false,"given":"Masayuki","family":"Ishihara","sequence":"first","affiliation":[{"name":"Department of Orthopedic Surgery, Kansai Medical University, Osaka 573-1191, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinichirou","family":"Taniguchi","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Kansai Medical University, Osaka 573-1191, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koki","family":"Kawashima","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Kansai Medical University, Osaka 573-1191, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Adachi","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Kansai Medical University, Osaka 573-1191, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaaki","family":"Paku","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Kansai Medical University, Osaka 573-1191, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoichi","family":"Tani","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Kansai Medical University, Osaka 573-1191, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muneharu","family":"Ando","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Kansai Medical University, Osaka 573-1191, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takanori","family":"Saito","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Kansai Medical University, Osaka 573-1191, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,3,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"E803","DOI":"10.1097\/BRS.0b013e318292b7b9","article-title":"Radiographical spinopelvic parameters and disability in the setting of adult spinal deformity: A prospective multicenter analysis","volume":"38","author":"Schwab","year":"2013","journal-title":"Spine"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3171\/2015.11.SPINE151036","article-title":"Prospective multicenter assessment of perioperative and minimum 2-year postoperative complication rates associated with adult spinal deformity surgery","volume":"25","author":"Smith","year":"2016","journal-title":"J. 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