{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T19:56:29Z","timestamp":1770148589660,"version":"3.49.0"},"reference-count":68,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2022,4,5]],"date-time":"2022-04-05T00:00:00Z","timestamp":1649116800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005888","name":"Medical University of Lodz","doi-asserted-by":"publisher","award":["502-03\/1-151-02\/502-14-281"],"award-info":[{"award-number":["502-03\/1-151-02\/502-14-281"]}],"id":[{"id":"10.13039\/501100005888","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: Kidneys play a key role in maintaining the acid\u2013base balance. The aim of this study was to evaluate the effect of a 3-month oral sodium bicarbonate administration on arterial wall stiffness, arterial pressure and serum nutritional markers in non-dialysed patients with chronic kidney disease (CKD) stages 3\u20135 and metabolic acidosis. Methods: Eighteen CKD patients with eGFR &lt; 45 mL\/min\/1.73 m2 and capillary blood bicarbonate (HCO3) &lt; 22 mmol\/L were enrolled in this single-centre, prospective study. Anthropometric parameters, pulse wave velocity, 24-h ambulatory blood pressure measurements, blood and urine parameters were assessed at the beginning and at the end of the study. The patients received supplementation with 2 g of sodium bicarbonate daily for three months. Results: A significant increase of pH: 7.32 \u00b1 0.06 to 7.36 \u00b1 0.06; p = 0.025, HCO3 from 18.7 mmol\/L (17.7\u201321.3) to 22.2 mmol\/L (20.2\u201323.9); p &lt; 0.001 and a decrease in base excess from \u22126.0 \u00b1 2.4 to \u22121.9 \u00b1 3.1 mmol\/L; p &lt; 0.001 were found. An increase in serum total protein from 62.7 \u00b1 6.9 to 65.8 \u00b1 6.2; p &lt; 0.013 and albumin from 37.3 \u00b1 5.4 to 39.4 \u00b1 4.8; p &lt; 0.037 but, also, NT-pro-BNP (N-Terminal Pro-B-Type Natriuretic Peptide) from 794.7 (291.2\u20131819.0) to 1247.10 (384.7\u20134545.0); p &lt; 0.006, CRP(C Reactive Protein) from 1.3 (0.7\u20132.9) to 2.8 (1.1\u20133.1); p &lt; 0.025 and PTH (parathyroid hormone) from 21.5 \u00b1 13.7 to 27.01 \u00b1 16.3; p &lt; 0.006 were observed, as well as an increase in erythrocyte count from 3.4 \u00b1 0.6 to 3.6 \u00b1 0.6; p &lt; 0.004, haemoglobin from 10.2 \u00b1 2.0 to 11.00 \u00b1 1.7; p &lt; 0.006 and haematocrit from 31.6 \u00b1 6.00 to 33.6 \u00b1 4.8; p &lt; 0.009. The mean eGFR during sodium bicarbonate administration did not change significantly: There were no significant differences in pulse wave velocity or in the systolic and diastolic BP values. Conclusion: The administration of sodium bicarbonate in non-dialysed CKD patients in stages 3\u20135 improves the parameters of metabolic acidosis and serum nutritional markers; however, it does not affect the blood pressure and vascular stiffness.<\/jats:p>","DOI":"10.3390\/medicina58040518","type":"journal-article","created":{"date-parts":[[2022,4,5]],"date-time":"2022-04-05T11:26:07Z","timestamp":1649157967000},"page":"518","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Effects of Oral Bicarbonate Supplementation on the Cardiovascular Risk Factors and Serum Nutritional Markers in Non-Dialysed Chronic Kidney Disease Patients"],"prefix":"10.3390","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1354-2074","authenticated-orcid":false,"given":"Katarzyna","family":"Szczeci\u0144ska","sequence":"first","affiliation":[{"name":"Department of Internal Medicine and Transplant Nephrology, Medical University of \u0141\u00f3d\u017a, 90-153 Lodz, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ma\u0142gorzata","family":"Wajdlich","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Hypertension and Kidney Transplantation, Medical University of \u0141\u00f3d\u017a, 92-213 Lodz, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6587-2502","authenticated-orcid":false,"given":"Maja","family":"Nowicka","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Transplant Nephrology, Medical University of \u0141\u00f3d\u017a, 90-153 Lodz, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0823-5440","authenticated-orcid":false,"given":"Micha\u0142","family":"Nowicki","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Hypertension and Kidney Transplantation, Medical University of \u0141\u00f3d\u017a, 92-213 Lodz, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3448-0682","authenticated-orcid":false,"given":"Ilona","family":"Kurnatowska","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Transplant Nephrology, Medical University of \u0141\u00f3d\u017a, 90-153 Lodz, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,4,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1053\/j.ajkd.2019.01.036","article-title":"Metabolic Acidosis in CKD: Core Curriculum 2019","volume":"74","author":"Raphael","year":"2019","journal-title":"Am. J. Kidney Dis."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1097\/MNH.0b013e32833b64fa","article-title":"Acidosis and progression of chronic kidney disease","volume":"19","author":"Yaqoob","year":"2010","journal-title":"Curr. Opin. Nephrol. Hypertens."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1038\/ki.2012.267","article-title":"Angiotensin II receptors mediate increased distal nephron acidification caused by acid retention","volume":"82","author":"Wesson","year":"2012","journal-title":"Kidney Int."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1681\/ASN.2008020159","article-title":"Timing of onset of CKD-related metabolic complications","volume":"20","author":"Moranne","year":"2009","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1111\/j.1523-1755.2004.00481.x","article-title":"Prevalence of acidosis and inflammation and their association with low serum albumin in chronic kidney disease","volume":"65","author":"Eustace","year":"2004","journal-title":"Kidney Int."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1053\/j.ajkd.2009.02.014","article-title":"Serum bicarbonate levels and the progression of kidney disease: A cohort study","volume":"54","author":"Shah","year":"2009","journal-title":"Am. J. Kid. Dis."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1001\/archinte.1979.03630470021010","article-title":"Serum electrolyte and acid base composition. The influence of graded degrees of chronic renal failure","volume":"139","author":"Widmer","year":"1979","journal-title":"Arch. Intern. Med."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1038\/nrneph.2010.33","article-title":"Metabolic acidosis: Pathophysiology, diagnosis and management","volume":"6","author":"Kraut","year":"2010","journal-title":"Nat. Rev. Nephrol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1111\/j.0894-0959.2004.17606.x","article-title":"Metabolic acidosis and malnutrition-inflammation complex syndrome in chronic renal failure","volume":"17","author":"Mehrotra","year":"2004","journal-title":"Semin. Dial."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1038\/sj.ki.5002647","article-title":"Dietary protein causes a decline in the glomerular filtration rate of the remnant kidney mediated by metabolic acidosis and endothelin receptors","volume":"73","author":"Phisitkul","year":"2008","journal-title":"Kidney Int."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1159\/000328742","article-title":"Activation of intrarenal renin-angiotensin system during metabolic acidosis","volume":"34","author":"Ng","year":"2011","journal-title":"Am. J. Nephrol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1471-2369-14-4","article-title":"High serum bicarbonate level within the normal range prevents the progression of chronic kidney disease in elderly chronic kidney disease patients","volume":"14","author":"Kanda","year":"2013","journal-title":"BMC Nephrol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1053\/j.ajkd.2013.01.017","article-title":"Association of serum bicarbonate with risk of renal and cardiovascular outcomes in CKD: A report from the Chronic Renal Insufficiency Cohort (CRIC) study","volume":"62","author":"Dobre","year":"2013","journal-title":"Am. J. Kidney"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1097\/MNH.0b013e32835dcbbe","article-title":"Does correction of metabolic acidosis slow chronic kidney disease progression?","volume":"22","author":"Goraya","year":"2013","journal-title":"Curr. Opin. Nephrol. Hypertens."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"6651367","DOI":"10.1155\/2021\/6651367","article-title":"Uremic Toxins, Oxidative Stress, Atherosclerosis in Chronic Kidney Disease, and Kidney Transplantation","volume":"2021","author":"Wojtaszek","year":"2021","journal-title":"Oxidat. Med. Cell Longev."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1093\/ndt\/gfn633","article-title":"Association of serum bicarbonate levels with mortality in patients with non-dialysis-dependent CKD","volume":"24","author":"Kovesdy","year":"2009","journal-title":"Nephrol. Dial. Transpl."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2395","DOI":"10.2215\/CJN.03730411","article-title":"Serum bicarbonate and mortality in stage 3 and stage 4 chronic kidney disease","volume":"6","author":"Navaneethan","year":"2011","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"ref_18","first-page":"1","article-title":"Kidney Disease: Improving Global Outcomes (KDIGO) CKD Work Group. KDIGO 2012 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease","volume":"3","author":"Levin","year":"2013","journal-title":"Kidney Int. Suppl."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1159\/000490475","article-title":"Diagnosis and Treatment of Metabolic Acidosis in Patients with Chronic Kidney Disease\u2014Position Statement of the Working Group of the Polish Society of Nephrology","volume":"43","author":"Adamczak","year":"2018","journal-title":"Kidney Blood Press Res."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1053\/j.ajkd.2018.09.004","article-title":"Tolerance to Sodium in Patients With CKD-Induced Metabolic Acidosis: Does the Accompanying Anion Matter?","volume":"73","author":"Bushinsky","year":"2019","journal-title":"Am. J. Kidney Dis."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"2075","DOI":"10.1681\/ASN.2008111205","article-title":"Bicarbonate supplementation slows progression CKD and improves nutritional status","volume":"20","author":"Varanugam","year":"2009","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1038\/ki.2010.129","article-title":"Daily oral sodium bicarbonate preserves glomerular filtration rate by slowing its decline in early hypertensive nephropathy","volume":"78","author":"Mahajan","year":"2010","journal-title":"Kidney Int."},{"key":"ref_23","first-page":"121","article-title":"Correction of metabolic acidosis improves muscle mass and renal function in chronic kidney disease stages 3 and 4: A randomized controlled trial","volume":"35","author":"Dubey","year":"2020","journal-title":"Nephrol. Dial. Transpl."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1038\/ki.2009.519","article-title":"Amelioration of metabolic acidosis in patients with low GFR reduced kidney endothelin production and kidney injury, and better preserved GFR","volume":"77","author":"Phisitkul","year":"2010","journal-title":"Kidney Int."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1053\/j.ajkd.2019.07.016","article-title":"Effects of Sodium Bicarbonate in CKD Stages 3 and 4: A Randomized, Placebo-Controlled, Multicenter Clinical Trial","volume":"75","author":"Melamed","year":"2020","journal-title":"Am. J. Kidney Dis."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1038\/ki.1986.215","article-title":"Chronic effects of dietary protein in the rat with intact and reduced renal mass","volume":"30","author":"Hostetter","year":"1986","journal-title":"Kidney Int."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1161\/HYPERTENSIONAHA.119.14240","article-title":"High Blood Pressure and Cardiovascular Disease","volume":"75","author":"Fuchs","year":"2020","journal-title":"Hypertension"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1097\/00004872-199715040-00006","article-title":"Prediction of mortality by ambulatory blood pressure monitoring versus screening blood pressure measurements: A pilot study in Ohasama","volume":"15","author":"Ohkubo","year":"1997","journal-title":"J. Hypertens."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1053\/j.ajkd.2020.05.006","article-title":"KDOQI Clinical Practice Guideline for Nutrition in CKD: 2020 Update","volume":"76","author":"Ikizler","year":"2020","journal-title":"Am. J. Kidney Dis."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"The BiCARB Study Group, Witham, M.D., and Band, M. (2020). Clinical and cost-effectiveness of oral sodium bicarbonate therapy for older patients with chronic kidney disease and low-grade acidosis (BiCARB): A pragmatic randomised, double-blind, placebo-controlled trial. BMC Med., 18.","DOI":"10.1186\/s12916-020-01542-9"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"3435","DOI":"10.1093\/ndt\/gfs354","article-title":"Salt intake in kidney disease\u2014A missed therapeutic opportunity?","volume":"27","author":"Navis","year":"2012","journal-title":"Nephrol. Dial. Transpl."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1097\/MNH.0000000000000073","article-title":"Dietary sodium restriction: A neglected therapeutic opportunity in chronic kidney disease","volume":"23","author":"Humalda","year":"2014","journal-title":"Curr. Opin. Nephrol. Hypertens."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1097\/00004872-199007000-00010","article-title":"Sodium bicarbonate and sodium chloride: Effects on blood pressure and electrolyte homeostasis in normal and hypertensive man","volume":"8","author":"Luft","year":"1990","journal-title":"J. Hypertens."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"708S","DOI":"10.1093\/ajcn\/65.2.708S","article-title":"Dietary sodium and blood pressure: Interactions with other nutrients","volume":"65","author":"Kotchen","year":"1997","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1172\/JCI108107","article-title":"NaHCO3 and NaCl tolerance in chronic renal failure","volume":"56","author":"Husted","year":"1975","journal-title":"J. Clin. Investig."},{"key":"ref_36","first-page":"21","article-title":"NaHCO3 and NaCl tolerance in chronic renal failure II","volume":"7","author":"Husted","year":"1977","journal-title":"Clin. Nephrol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1056\/NEJM198710223171702","article-title":"\u201cSalt-sensitive\u201d essential hypertension in men. Is the sodium ion alone important?","volume":"317","author":"Kurtz","year":"1987","journal-title":"N. Engl. J. Med."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1097\/00004872-198808000-00003","article-title":"A randomized crossover study to compare the blood pressure response to sodium loading with and without chloride in patients with essential hypertension","volume":"6","author":"Shore","year":"1988","journal-title":"J. Hypertens."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"80","DOI":"10.5049\/EBP.2014.12.2.80","article-title":"Effect of Bicarbonate Supplementation on Renal Function and Nutritional Indices in Predialysis Advanced Chronic Kidney Disease Electrolyte","volume":"12","author":"Jeong","year":"2014","journal-title":"Electrolytes Blood Press."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/08860220500461187","article-title":"Effects of correction of metabolic acidosis on blood urea and bone metabolism in patients with mild to moderate chronic kidney disease: A prospective randomized single blind controlled trial","volume":"28","author":"Mathur","year":"2006","journal-title":"Ren. Fail."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"S21","DOI":"10.1111\/j.1523-1755.2005.09503.x","article-title":"Risks of chronic metabolic acidosis in patients with chronic kidney disease","volume":"95","author":"Kopple","year":"2005","journal-title":"Kidney Int. Suppl."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1159\/000454783","article-title":"Serum Bicarbonate is Associated with Heart Failure in the Multi-Ethnic Study of Atherosclerosis (MESA)","volume":"45","author":"Kendrick","year":"2017","journal-title":"Am. J. Nephrol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"gfz103.SP046","DOI":"10.1093\/ndt\/gfz103.SP046","article-title":"Effect of sodium bicarbonate load on 24-hour ambulatory blood pressure measurements in patients with chronic metabolic acidosis and chronic kidney disease: Preliminary results of the SOBIC study","volume":"34","author":"Riesenhuber","year":"2019","journal-title":"Nephrol. Dial. Transpl."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Hu, M.K., Soiza, R.L., and Witham, M.D. (2019). Oral bicarbonate therapy in chronic kidney disease: A systematic review and meta-analysis of randomised controlled trial. J. Clin. Med., 8.","DOI":"10.3390\/jcm8020208"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.2215\/CJN.13091118","article-title":"Effects of treatment of metabolic acidosis in CKD: A systematic review and meta-analysis","volume":"14","author":"Navaneethan","year":"2019","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Dong, L., Li, Z., Leffler, N.R., Asch, A.S., Chi, J.T., and Yang, L.V. (2013). Acidosis activation of the proton-sensing GPR4 receptor stimulates vascular endothelial cell inflammatory responses revealed by transcriptome analysis. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0061991"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"F830","DOI":"10.1152\/ajprenal.00587.2010","article-title":"Acid retention accompanies reduced GFR in humans and increases plasma levels of endothelin and aldosterone","volume":"300","author":"Wesson","year":"2011","journal-title":"Am. J. Physiol. Renal. Physiol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"C82","DOI":"10.1152\/ajpcell.00287.2006","article-title":"Angiotensin II cell signaling: Physiological and pathological effects in the cardiovascular system","volume":"292","author":"Mehta","year":"2007","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1053\/j.ajkd.2007.07.012","article-title":"Association of carotid intima-medial thickness and indices of arterial stiffness with cardiovascular disease outcomes in CKD","volume":"50","author":"Zoungas","year":"2007","journal-title":"Am. J. Kidney Dis."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1161\/HYPERTENSIONAHA.112.197210","article-title":"Large artery stiffening and remodeling are independently associated with all-cause mortality and cardiovascular events in chronic kidney disease","volume":"60","author":"Karras","year":"2012","journal-title":"Hypertension"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1161\/CIRCHEARTFAILURE.113.001041","article-title":"Arterial stiffness, central pressures, and incident hospitalized heart failure in the chronic renal insufficiency cohort study","volume":"7","author":"Chirinos","year":"2014","journal-title":"Circ. Heart Fail."},{"key":"ref_52","first-page":"647","article-title":"Alkalinization potentiates vascular calcium deposition in an uremic milieu","volume":"22","author":"Deudero","year":"2009","journal-title":"J. Nephrol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1046\/j.1523-1755.2000.00260.x","article-title":"Chronic metabolic acidosis in azotemic rats on a high-phosphate diet halts the progression of renal disease","volume":"58","author":"Jara","year":"2000","journal-title":"Kidney Int."},{"key":"ref_54","first-page":"1572","article-title":"Relationship of acid-base status with arterial stiffness in community-living elders: The Health ABC Study","volume":"33","author":"Chen","year":"2018","journal-title":"Nephrol. Dial. Transpl."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"16139","DOI":"10.1038\/s41598-019-52499-6","article-title":"Metabolic acidosis is associated with pulse wave velocity in chronic kidney disease: Results from the KNOW-CKD Study","volume":"9","author":"Hyo","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1093\/ndt\/gfn541","article-title":"Haemodynamic consequences of changing bicarbonate and calcium concentrations in haemodialysis fluids","volume":"24","author":"Gabutti","year":"2009","journal-title":"Nephrol. Dial. Transpl."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1681056","DOI":"10.1155\/2018\/1681056","article-title":"The association between intradialytic hypertension and metabolic disorders in end stage renal disease","volume":"2018","author":"Raikou","year":"2018","journal-title":"Int. J. Hypertens."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1172\/JCI117668","article-title":"Chronic metabolic acidosis decreases albumin synthesis and induces negative nitrogen balance in humans","volume":"1","author":"Ballmer","year":"1995","journal-title":"J. Clin. Investig."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1146\/annurev.nutr.21.1.343","article-title":"Nutritional management of maintenance dialysis patients: Why aren\u2019t we doing better?","volume":"21","author":"Mehrotra","year":"2001","journal-title":"Annu. Rev. Nutr."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1007\/s40620-019-00656-5","article-title":"Treatment of metabolic acidosis with sodium bicarbonate delays progression of chronic kidney disease: The UBI Study","volume":"32","author":"Bellasi","year":"2019","journal-title":"J. Nephrol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"91","DOI":"10.4103\/ijn.IJN_93_19","article-title":"A Study on Effect of Bicarbonate Supplementation on the Progression of Chronic Kidney Disease","volume":"30","author":"Alva","year":"2020","journal-title":"Indian J. Nephrol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1053\/jren.2002.35298","article-title":"Effect of the correction of metabolic acidosis on nutritional status in elderly patients with chronic renal failure","volume":"12","author":"Verove","year":"2002","journal-title":"J. Ren. Nutr."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1007\/s12185-012-1223-6","article-title":"Acidic milieu augments the expression of hepcidin, the central regulator of iron homeostasis","volume":"96","author":"Mizumoto","year":"2012","journal-title":"Int. J. Hematol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1681\/ASN.2011111078","article-title":"Mechanism of anaemia Mechanism of anaemia in CKD","volume":"23","author":"Babitt","year":"2012","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1111\/j.1440-1797.2006.00674.x","article-title":"Can acidosis and hyperphosphataemia result in increased erythropoietin dosing in haemodialysis patients?","volume":"11","author":"Diskin","year":"2006","journal-title":"Nephrology"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.biopha.2015.02.012","article-title":"The effect of sodium bicarbonate on cytokine secretion in CKD patients with metabolic acidosis","volume":"71","author":"Ori","year":"2015","journal-title":"Biomed. Pharmacother."},{"key":"ref_67","first-page":"917","article-title":"Use of a Single Baseline Versus Multiyear 24-Hour Urine Collection for Estimation of Long-Term Sodium Intake and Associated Cardiovascular and Renal Risk","volume":"10","author":"Vogt","year":"2017","journal-title":"Circulation"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1093\/aje\/kwt066","article-title":"Estimating 24-Hour Urinary Sodium Excretion from Casual Urinary Sodium Concentrations in Western Populations: The INTERSALT Study","volume":"11","author":"Brown","year":"2013","journal-title":"Am. J. 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