{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T05:44:34Z","timestamp":1782452674192,"version":"3.54.5"},"reference-count":24,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2022,4,15]],"date-time":"2022-04-15T00:00:00Z","timestamp":1649980800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007770","name":"Ministry of Science and Environmental Protection","doi-asserted-by":"publisher","award":["175008)"],"award-info":[{"award-number":["175008)"]}],"id":[{"id":"10.13039\/100007770","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: Despite the relatively large number of publications concerning the validation of these models, there is currently no solid evidence that they can be used with absolute precision to predict survival. The goal of this study is to identify preoperative factors that influenced 30-day mortality and to create a predictive model after open ruptured abdominal aortic aneurysm (RAAA) repair. Materials and Methods: This was a retrospective single-center cohort study derived from a prospective collected database, between 1 January 2009 and 2016. Multivariate logistic regression analysis was used to identify all significant predictive factors. Variables that were identified in the multivariate analysis were dichotomized at standard levels, and logistic regression was used for the analysis. To ensure that dichotomized variables were not overly simplistic, the C statistic was evaluated for both dichotomized and continuous models. Results: There were 500 patients with complete medical data included in the analysis during the study period. Of them, 37.6% were older than 74 years, and 83.8% were males. Multivariable logistic regression showed five variables that were predictive of mortality: age &gt; 74 years (OR = 4.01, 95%CI 2.43\u20136.26), loss of consciousness (OR = 2.21, 95%CI 1.11\u20134.40), previous myocardial infarction (OR = 2.35, 95%CI 1.19\u20134.63), development of ventricular arrhythmia (OR = 4.54, 95%CI 1.75\u201311.78), and DAP &lt; 60 mmHg (OR = 2.32, 95%CI 1.17\u20134.62). Assigning 1 point for each variable, patients were stratified according to the preoperative RAAA mortality risk score (range 0\u20135). Patients with 1 point suffered 15.3% mortality and 3 points 68.2% mortality, while all patients with 5 points died. Conclusions: This preoperative RAAA score identified risk factors readily assessed at the bedside and provides an accurate prediction of 30-day mortality after open repair of RAAA.<\/jats:p>","DOI":"10.3390\/medicina58040549","type":"journal-article","created":{"date-parts":[[2022,4,19]],"date-time":"2022-04-19T01:03:01Z","timestamp":1650330181000},"page":"549","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Identification of Risk Factors and Development of Predictive Risk Score Model for Mortality after Open Ruptured Abdominal Aortic Aneurysm Repair"],"prefix":"10.3390","volume":"58","author":[{"given":"Ivan","family":"Tomic","sequence":"first","affiliation":[{"name":"Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia"},{"name":"Clinic for Vascular and Endovascular Surgery, Clinical Centre of Serbia, 11000 Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petar","family":"Zlatanovic","sequence":"additional","affiliation":[{"name":"Clinic for Vascular and Endovascular Surgery, Clinical Centre of Serbia, 11000 Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miroslav","family":"Markovic","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia"},{"name":"Clinic for Vascular and Endovascular Surgery, Clinical Centre of Serbia, 11000 Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milos","family":"Sladojevic","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia"},{"name":"Clinic for Vascular and Endovascular Surgery, Clinical Centre of Serbia, 11000 Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Perica","family":"Mutavdzic","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia"},{"name":"Clinic for Vascular and Endovascular Surgery, Clinical Centre of Serbia, 11000 Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ranko","family":"Trailovic","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia"},{"name":"Clinic for Vascular and Endovascular Surgery, Clinical Centre of Serbia, 11000 Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ksenija","family":"Jovanovic","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia"},{"name":"Clinic for Vascular and Endovascular Surgery, Clinical Centre of Serbia, 11000 Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Matejevic","sequence":"additional","affiliation":[{"name":"Clinic for Vascular and Endovascular Surgery, Clinical Centre of Serbia, 11000 Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8091-2461","authenticated-orcid":false,"given":"Biljana","family":"Milicic","sequence":"additional","affiliation":[{"name":"Department for Statistics and Informatics, Faculty of Dental Medicine, University of Belgrade, 11000 Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lazar","family":"Davidovic","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia"},{"name":"Clinic for Vascular and Endovascular Surgery, Clinical Centre of Serbia, 11000 Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,4,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/j.ejvs.2007.11.019","article-title":"Meta analysis on mortality of ruptured abdominal aortic aneurysms","volume":"35","author":"Hoornweg","year":"2008","journal-title":"Eur. J. Vasc. Endovasc. Surg."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1002\/bjs.9356","article-title":"Cost-effectiveness and cost-utility of endovascular versus open repair of ruptured abdominal aortic aneurysm in the Amsterdam Acute Aneurysm Trial","volume":"101","author":"Kapma","year":"2014","journal-title":"Br. J. Surg."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"IMPROVE Trial Investigators, Powell, J.T., Sweeting, M.J., Thompson, M.M., Ashleigh, R., Bell, R., Gomes, M., Greenhalgh, R.M., Grieve, R., and Heatley, F. (2014). Endovascular or open repair strategy for ruptured abdominal aortic aneurysm: 30 day outcomes from IMPROVE randomised trial. BMJ, 348, 7661.","DOI":"10.1136\/bmj.f7661"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/j.ejvs.2006.12.011","article-title":"The Amsterdam Acute Aneurysm Trial: Suitability and application rate for endovascular repair of ruptured abdominal aortic aneurysms","volume":"33","author":"Hoornweg","year":"2007","journal-title":"Eur. J. Vasc. Endovasc. Surg."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/j.jamcollsurg.2012.12.028","article-title":"Trends in treatment of ruptured abdominal aortic aneurysm: Impact of endovascular repair and implications for future care","volume":"216","author":"Park","year":"2013","journal-title":"J. Am. Coll. Surg."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1002\/bjs.6911","article-title":"Propensity scored analysis of outcomes after ruptured abdominal aortic aneurysm","volume":"97","author":"Holt","year":"2010","journal-title":"Br. J. Surg."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1002\/bjs.9235","article-title":"Systematic review and meta-analysis of population-based mortality from ruptured abdominal aortic aneurysm","volume":"100","author":"Reimerink","year":"2013","journal-title":"Br. J. Surg."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1016\/j.jvs.2006.07.041","article-title":"The Hardman index in patients operated on for ruptured abdominal aortic aneurysm: A systematic review","volume":"44","author":"Acosta","year":"2006","journal-title":"J. Vasc. Surg."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1016\/j.jvs.2016.07.121","article-title":"Predictive models for mortality after ruptured aortic aneurysm repair do not predict futility and are not useful for clinical decision making","volume":"64","author":"Thompson","year":"2016","journal-title":"J. Vasc. Surg."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.ejvs.2018.09.020","article-title":"ESVS Guidelines Committee. Editor\u2019s Choice\u2014European Society for Vascular Surgery (ESVS) 2019 Clinical Practice Guidelines on the Management of Abdominal Aorto-iliac Artery Aneurysms","volume":"57","author":"Wanhainen","year":"2019","journal-title":"Eur. J. Vasc. Endovasc. Surg."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.avsg.2016.02.037","article-title":"The Rationale for Continuing Open Repair of Ruptured Abdominal Aortic Aneurysm","volume":"36","author":"Markovic","year":"2016","journal-title":"Ann. Vasc. Surg."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.jclinepi.2007.11.008","article-title":"The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: Guidelines for reporting observational studies","volume":"61","author":"Altman","year":"2008","journal-title":"J. Clin. Epidemiol."},{"key":"ref_13","first-page":"41","article-title":"Glasgow aneurysm score","volume":"2","author":"Samy","year":"1994","journal-title":"Cardiovasc. Surg."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0741-5214(05)80042-4","article-title":"Ruptured abdominal aortic aneurysms: Who should be offered surgery?","volume":"23","author":"Hardman","year":"1996","journal-title":"J. Vasc. Surg."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/S0741-5214(96)70077-0","article-title":"Predictors of death in nonruptured and ruptured abdominal aortic aneurysms","volume":"24","author":"Chen","year":"1996","journal-title":"J. Vasc. Surg."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"2243","DOI":"10.1007\/s00268-007-9181-5","article-title":"Predictors of outcome after abdominal aortic aneurysm rupture: Edinburgh Ruptured Aneurysm Score","volume":"31","author":"Tambyraja","year":"2007","journal-title":"World J. Surg."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.jvs.2012.08.120","article-title":"Derivation and validation of a practical risk score for prediction of mortality after open repair of ruptured abdominal aortic aneurysms in a U.S. regional cohort and comparison to existing scoring systems","volume":"57","author":"Robinson","year":"2013","journal-title":"J. Vasc. Surg."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.jvs.2015.02.038","article-title":"Prediction of in-hospital mortality after ruptured abdominal aortic aneurysm repair using an artificial neural network","volume":"62","author":"Wise","year":"2015","journal-title":"J. Vasc. Surg."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1016\/j.jvs.2017.12.075","article-title":"Preoperative risk score for the prediction of mortality afrer repair of ruptured abdominal aortic aneurysms","volume":"68","author":"Garland","year":"2018","journal-title":"J. Vasc. Surg."},{"key":"ref_20","unstructured":"Meguid, R.A., Brooke, B.S., Perler, B.A., and Freischlag, J.A. (2008, January 12). Impact of hospital teaching status on survival from ruptured abdominal aneurysm repair. Proceedings of the Annual Meeting of Eastern Vascular Society, Boston, MA, USA."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.avsg.2014.07.027","article-title":"Endovascular repair of ruptured and symptomatic abdominal aortic aneurysms using a structured protocol in a community teaching hospital","volume":"29","author":"Oyague","year":"2015","journal-title":"Ann. Vasc. Surg."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1016\/j.jvs.2013.02.025","article-title":"Complete replacement of open repair for ruptured abdominal aortic aneurysms by endovascular aneurysm repair. A two-center 14-year experience","volume":"57","author":"Mayer","year":"2013","journal-title":"J. Vasc. Surg."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/j.jvs.2008.11.002","article-title":"Endovascular treatment of ruptured abdominal aortic aneurysms in the United States (2001\u20132006): A significant survival benefit over open repair is independently associated with increased institutional volume","volume":"49","author":"McPhee","year":"2009","journal-title":"J. Vasc. Surg."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1053\/ejvs.2002.1928","article-title":"A cost analysis of surgery for ruptured abdominal aortic aneurysm","volume":"26","author":"Tang","year":"2003","journal-title":"Eur J. Vasc. Endovasc. Surg."}],"container-title":["Medicina"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1648-9144\/58\/4\/549\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T22:55:14Z","timestamp":1760136914000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1648-9144\/58\/4\/549"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,15]]},"references-count":24,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2022,4]]}},"alternative-id":["medicina58040549"],"URL":"https:\/\/doi.org\/10.3390\/medicina58040549","relation":{},"ISSN":["1648-9144"],"issn-type":[{"value":"1648-9144","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,15]]}}}