{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T16:44:32Z","timestamp":1794329072551,"version":"4.9.0"},"reference-count":27,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2022,4,19]],"date-time":"2022-04-19T00:00:00Z","timestamp":1650326400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Tea tree oil is an essential oil obtained by distillation from the leaves and terminal branchlets of Melaleuca alternifolia and is now present in numerous products for body care and self-medication. We report a case of allergic contact dermatitis to tea tree oil in a young man who was applying a lotion containing tea tree oil on a wart localized on the plantar aspect of the right big toe, which had previously been treated with cryotherapy. He developed a severe eczematous eruption on the right foot and the right leg, with subsequent id reactions affecting the right thigh, the contralateral lower limb, the trunk and the upper limbs. The lotion was discontinued, and the dermatitis resolved after topical corticosteroid therapy. Patch testing with the aforementioned lotion 10% pet. and oxidized tea tree oil 5% pet. identified tea tree oil as the culprit agent of the dermatitis. This case report confirms that products made of natural ingredients, often perceived to be harmless, can cause allergic reactions.<\/jats:p>","DOI":"10.3390\/medicina58050561","type":"journal-article","created":{"date-parts":[[2022,4,19]],"date-time":"2022-04-19T22:07:26Z","timestamp":1650406046000},"page":"561","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Spreading Allergic Contact Dermatitis to Tea Tree Oil in an Over-the-Counter Product Applied on a Wart"],"prefix":"10.3390","volume":"58","author":[{"given":"Francesca","family":"Ambrogio","sequence":"first","affiliation":[{"name":"Section of Dermatology, Department of Biomedical Science and Human Oncology, University of Bari, 70124 Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caterina","family":"Foti","sequence":"additional","affiliation":[{"name":"Section of Dermatology, Department of Biomedical Science and Human Oncology, University of Bari, 70124 Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0325-4316","authenticated-orcid":false,"given":"Gerardo","family":"Cazzato","sequence":"additional","affiliation":[{"name":"Section of Pathology, Department of Emergency and Organ Transplantation (DETO), University of Bari Aldo Moro, 70124 Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edoardo","family":"Mortato","sequence":"additional","affiliation":[{"name":"Section of Dermatology, Department of Biomedical Science and Human Oncology, University of Bari, 70124 Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stella","family":"Mazzoccoli","sequence":"additional","affiliation":[{"name":"Section of Dermatology, Department of Biomedical Science and Human Oncology, University of Bari, 70124 Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Paola","family":"De Caro","sequence":"additional","affiliation":[{"name":"Section of Dermatology, Department of Biomedical Science and Human Oncology, University of Bari, 70124 Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicoletta","family":"Cassano","sequence":"additional","affiliation":[{"name":"Dermatology and Venereology Private Practice, 70100 Bari, Italy"},{"name":"Dermatology and Venereology Private Practice, 76121 Barletta, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gino Antonio","family":"Vena","sequence":"additional","affiliation":[{"name":"Dermatology and Venereology Private Practice, 70100 Bari, Italy"},{"name":"Dermatology and Venereology Private Practice, 76121 Barletta, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianfranco","family":"Calogiuri","sequence":"additional","affiliation":[{"name":"Hospital Vito Fazzi, 73100 Lecce, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5559-9722","authenticated-orcid":false,"given":"Paolo","family":"Romita","sequence":"additional","affiliation":[{"name":"Section of Dermatology, Department of Biomedical Science and Human Oncology, University of Bari, 70124 Bari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,4,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.abd.2020.11.003","article-title":"Update on human papilloma virus\u2014part I: Epidemiology, pathogenesis, and clinical spectrum","volume":"96","author":"Vieira","year":"2021","journal-title":"An. 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