{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T23:41:28Z","timestamp":1760139688144,"version":"build-2065373602"},"reference-count":46,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2022,4,23]],"date-time":"2022-04-23T00:00:00Z","timestamp":1650672000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Primary fallopian tube carcinoma (PFTC) has characteristics similar to those of ovarian carcinoma. The typical course of PFTC metastasis includes peritoneal dissemination and pelvic and paraaortic lymph node metastasis, while inguinal lymph node metastasis is rare. Moreover, the initial presentation of PFTC with an inguinal tumor is extremely rare. A 77-year-old postmenopausal woman presented with a massive 12-cm inguinal subcutaneous tumor. After tumor resection, histopathological and immunohistochemical analysis showed that the tumor was a high-grade serous carcinoma of gynecological origin. Subsequent surgery for total hysterectomy with bilateral salpingo-oophorectomy revealed that the tumor developed in the fallopian tube. She received adjuvant chemotherapy with carboplatin and paclitaxel, followed by maintenance therapy with niraparib. There has been no recurrence or metastasis 9 months after the second surgery. We reviewed the literature for cases of PFTC and ovarian carcinoma that initially presented with an inguinal tumor. In compliance with the Preferred Reporting Items for Systematic Reviews guidelines, a systematic literature search was performed through 31 January 2022 using the PubMed and Google scholar databases and identified 14 cases. In half of them, it was difficult to identify the primary site using preoperative imaging modalities. Disease recurrence occurred in two cases; thus, the prognosis of this type of PFTC appears to be good.<\/jats:p>","DOI":"10.3390\/medicina58050581","type":"journal-article","created":{"date-parts":[[2022,4,23]],"date-time":"2022-04-23T21:39:45Z","timestamp":1650749985000},"page":"581","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Primary Fallopian Tube Carcinoma Presenting with a Massive Inguinal Tumor: A Case Report and Literature Review"],"prefix":"10.3390","volume":"58","author":[{"given":"Michihide","family":"Maeda","sequence":"first","affiliation":[{"name":"Department of Gynecology, Osaka International Cancer Institute, Osaka 541-8567, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsuyoshi","family":"Hisa","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Osaka International Cancer Institute, Osaka 541-8567, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinya","family":"Matsuzaki","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Osaka International Cancer Institute, Osaka 541-8567, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuichi","family":"Ohe","sequence":"additional","affiliation":[{"name":"Department of Dermatologic Oncology, Osaka International Cancer Institute, Osaka 541-8567, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigenori","family":"Nagata","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology, Osaka International Cancer Institute, Osaka 541-8567, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Misooja","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Forensic Medicine, School of Medicine, Kindai University, Osaka 589-8511, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seiji","family":"Mabuchi","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Osaka International Cancer Institute, Osaka 541-8567, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shoji","family":"Kamiura","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Osaka International Cancer Institute, Osaka 541-8567, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,4,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1200\/JOP.18.00662","article-title":"Fallopian Tube Carcinoma","volume":"15","author":"Stasenko","year":"2019","journal-title":"J. Oncol. Pract."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1002\/ijgo.13878","article-title":"Cancer of the ovary, fallopian tube, and peritoneum: 2021 update","volume":"155","author":"Berek","year":"2021","journal-title":"Int. J. Gynecol. Obstet."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1097\/GCO.0b013e328011a21f","article-title":"The distal fallopian tube: A new model for pelvic serous carcinogenesis","volume":"19","author":"Crum","year":"2007","journal-title":"Curr. Opin. Obstet. Gynecol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1097\/PAS.0b013e3181cf3d79","article-title":"The origin and pathogenesis of epithelial ovarian cancer: A proposed unifying theory","volume":"34","author":"Kurman","year":"2010","journal-title":"Am. J. Surg. Pathol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1097\/PAS.0b013e3181ef7b16","article-title":"Are All Pelvic (Nonuterine) Serous Carcinomas of Tubal Origin?","volume":"34","author":"Przybycin","year":"2010","journal-title":"Am. J. Surg. Pathol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"188.e1","DOI":"10.1016\/j.ajog.2014.08.016","article-title":"Survival differences in women with serous tubal, ovarian, peritoneal, and uterine carcinomas","volume":"212","author":"Usach","year":"2015","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.ygyno.2007.09.018","article-title":"The incidence of primary fallopian tube cancer in the United States","volume":"107","author":"Stewart","year":"2007","journal-title":"Gynecol. Oncol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1006\/gyno.1998.5267","article-title":"Carcinoma of the Fallopian Tube: A Clinicopathological Study of 105 Cases with Observations on Staging and Prognostic Factors","volume":"72","author":"Young","year":"1999","journal-title":"Gynecol. Oncol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"2705","DOI":"10.1001\/jama.291.22.2705","article-title":"Frequency of Symptoms of Ovarian Cancer in Women Presenting to Primary Care Clinics","volume":"291","author":"Goff","year":"2004","journal-title":"J. Am. Med Assoc."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"4151","DOI":"10.1002\/cncr.33829","article-title":"Factors impacting the time to ovarian cancer diagnosis based on classic symptom presentation in the United States","volume":"127","author":"Huepenbecker","year":"2021","journal-title":"Cancer"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1007\/s10147-010-0030-4","article-title":"Supraclavicular lymph node metastasis as the initial presentation of primary fallopian tube carcinoma","volume":"15","author":"Sakurai","year":"2010","journal-title":"Int. J. Clin. Oncol."},{"key":"ref_12","first-page":"4801","article-title":"Long-term survival of a patient with fallopian tube cancer presenting with a supraclavicular mass","volume":"20","author":"Scholz","year":"2001","journal-title":"Anticancer Res."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"e56","DOI":"10.3802\/jgo.2018.29.e56","article-title":"Practice guidelines for management of ovarian cancer in Korea: A Korean Society of Gynecologic Oncology Consensus Statement","volume":"29","author":"Suh","year":"2018","journal-title":"J. Gynecol. Oncol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1007\/s00404-014-3364-8","article-title":"The new FIGO staging system for ovarian, fallopian tube, and primary peritoneal cancer","volume":"290","author":"Zeppernick","year":"2014","journal-title":"Arch. Gynecol. Obstet."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.ygyno.2018.01.030","article-title":"Trends in the incidence of serous fallopian tube, ovarian, and peritoneal cancer in the US","volume":"149","author":"Liao","year":"2018","journal-title":"Gynecol. Oncol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"721.e1","DOI":"10.1016\/j.ajog.2020.04.028","article-title":"The rapid adoption of opportunistic salpingectomy at the time of hysterectomy for benign gynecologic disease in the United States","volume":"223","author":"Mandelbaum","year":"2020","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1002\/path.1000","article-title":"Dysplastic changes in prophylactically removed Fallopian tubes of women predisposed to developing ovarian cancer","volume":"195","author":"Piek","year":"2001","journal-title":"J. Pathol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.fertnstert.2014.03.041","article-title":"Tubal ligation, hysterectomy, unilateral oophorectomy, and risk of ovarian cancer in the Nurses\u2019 Health Studies","volume":"102","author":"Rice","year":"2014","journal-title":"Fertil. Steril."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"ACOG Committee (2019). Opinion No. 774 Summary: Opportunistic Salpingectomy as a Strategy for Epithelial Ovarian Cancer Prevention. Obs. Gynecol., 133, 842\u2013843.","DOI":"10.1097\/AOG.0000000000003165"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"dju410","DOI":"10.1093\/jnci\/dju410","article-title":"Ovarian Cancer Risk After Salpingectomy: A Nationwide Population-Based Study","volume":"107","author":"Falconer","year":"2014","journal-title":"J. Natl. Cancer Inst."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.jclinepi.2021.02.003","article-title":"Updating guidance for reporting systematic reviews: Development of the PRISMA 2020 statement","volume":"134","author":"Page","year":"2021","journal-title":"J. Clin. Epidemiol."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Matsuzaki, S., Nagase, Y., Ueda, Y., Kakuda, M., Maeda, M., Matsuzaki, S., and Kamiura, S. (2021). Placenta Previa Complicated with Endometriosis: Contemporary Clinical Management, Molecular Mechanisms, and Future Research Opportunities. Biomedicines, 9.","DOI":"10.3390\/biomedicines9111536"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Matsuzaki, S., Klar, M., Chang, E.J., Matsuzaki, S., Maeda, M., Zhang, R.H., Roman, L.D., and Matsuo, K. (2021). Minimally Invasive Surgery and Surgical Volume-Specific Survival and Perioperative Outcome: Unmet Need for Evidence in Gynecologic Malignancy. J. Clin. Med., 10.","DOI":"10.3390\/jcm10204787"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Matsuzaki, S., Ueda, Y., Nagase, Y., Matsuzaki, S., Kakuda, M., Kakuda, S., Sakaguchi, H., Hisa, T., and Kamiura, S. (2022). Placenta Accreta Spectrum Disorder Complicated with Endometriosis: Systematic Review and Meta-Analysis. Biomedicines, 10.","DOI":"10.3390\/biomedicines10020390"},{"key":"ref_25","first-page":"385","article-title":"Normal Size Ovary Carcinoma Syndrome with Inguinal Ovarian Cancer Lymph Node Metastases\u2014A Case Report and Literature Review","volume":"32","author":"Balescu","year":"2018","journal-title":"In Vivo"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.jnci.2017.01.003","article-title":"Ovarian cancer with metastatic inguinal lymphadenopathy: A case series and literature review","volume":"29","author":"Metwally","year":"2017","journal-title":"J. Egypt. Natl. Cancer Inst."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/1757-2215-7-20","article-title":"Ovarian cancer initially presenting with isolated ipsilateral superficial inguinal lymph node metastasis: A case study and review of the literature","volume":"7","author":"Yang","year":"2014","journal-title":"J. Ovarian Res."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"3","DOI":"10.7243\/2049-7962-2-3","article-title":"Ovarian carcinoma in normal size ovaries with inguinal lymph node metastasis: A case report inhibitor-like mechanism","volume":"2","author":"Deka","year":"2013","journal-title":"J. Cancer Ther. Res."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.ejogrb.2007.02.025","article-title":"An enlarged groin node as first manifestation of a malignancy: Don\u2019t forget the ovaries","volume":"138","author":"Oei","year":"2008","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"427","DOI":"10.47102\/annals-acadmedsg.V36N6p427","article-title":"Ovarian carcinoma presenting with isolated contralateral inguinal lymph node metastasis: A case report","volume":"36","author":"Ang","year":"2007","journal-title":"Ann. Acad. Med. Singap."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/j.ygyno.2006.06.023","article-title":"Inguinal node metastasis as the initial presentation of primary fallopian tube cancer","volume":"103","author":"Cho","year":"2006","journal-title":"Gynecol. Oncol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/j.ygyno.2005.09.026","article-title":"Ovarian cancer, diagnosed with PET, with bilateral inguinal lymphadenopathy as primary presenting sign","volume":"100","author":"Manci","year":"2006","journal-title":"Gynecol. Oncol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1006\/gyno.2001.6141","article-title":"Inguinal Lymph Node Metastasis: An Unusual Presentation of Fallopian Tube Carcinoma","volume":"81","author":"Tjalma","year":"2001","journal-title":"Gynecol. Oncol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1111\/j.1479-828X.1996.tb02940.x","article-title":"Massive Groin Node Metastasis as Presenting Sign of Squamous Cell Carcinoma of the Fallopian Tube","volume":"36","author":"Cormio","year":"1996","journal-title":"Aust. N. Zeal. J. Obstet. Gynaecol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1006\/gyno.1993.1177","article-title":"Ovarian Carcinoma Presenting with Inguinal Metastatic Lymphadenopathy 33 Months Prior to Intraabdominal Disease","volume":"50","author":"Kehoe","year":"1993","journal-title":"Gynecol. Oncol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/0090-8258(92)90291-P","article-title":"Endometrioid carcinoma of the ovary presenting with an enlarged inguinal lymph node without evidence of abdominal carcinomatosis","volume":"45","author":"Mcgonigle","year":"1992","journal-title":"Gynecol. Oncol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/0002-9378(53)90306-8","article-title":"Primary ovarian cystadenocarcinoma: Solitary metastasis to contralateral inguinal lymph node","volume":"66","author":"Shulman","year":"1953","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.ygyno.2017.07.124","article-title":"Should epithelial ovarian carcinoma metastatic to the inguinal lymph nodes be assigned stage IVB?","volume":"147","author":"Nasioudis","year":"2017","journal-title":"Gynecol. Oncol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1097\/IGC.0000000000000514","article-title":"Understanding Lymphatic Drainage Pathways of the Ovaries to Predict Sites for Sentinel Nodes in Ovarian Cancer","volume":"25","author":"Kleppe","year":"2015","journal-title":"Int. J. Gynecol. Cancer"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"324.e1","DOI":"10.1016\/j.ajog.2019.05.005","article-title":"Sentinel-node biopsy in early-stage ovarian cancer: Preliminary results of a prospective multicentre study (SELLY)","volume":"221","author":"Uccella","year":"2019","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.ijscr.2019.12.021","article-title":"A case report of advanced ovarian cancer detected due to an inguinal metastasis in the canal of Nuck","volume":"66","author":"Togashi","year":"2019","journal-title":"Int. J. Surg. Case Rep."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.clinimag.2018.02.003","article-title":"Anatomy and pathology of the canal of Nuck","volume":"51","author":"Nasser","year":"2018","journal-title":"Clin. Imaging"},{"key":"ref_43","first-page":"737","article-title":"Nuck canal endometriosis: MR imaging findings and clinical features","volume":"35","author":"Gaeta","year":"2010","journal-title":"Gastrointest. Radiol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1002\/1097-0142(197803)41:3<919::AID-CNCR2820410320>3.0.CO;2-A","article-title":"Inguinal node metastases","volume":"41","author":"Zaren","year":"1978","journal-title":"Cancer"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"735","DOI":"10.3892\/ol.2013.1121","article-title":"PAX8 is a novel marker for differentiating between various types of tumor, particularly ovarian epithelial carcinomas","volume":"5","author":"Xiang","year":"2013","journal-title":"Oncol. Lett."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1056\/NEJMoa1808424","article-title":"A Randomized Trial of Lymphadenectomy in Patients with Advanced Ovarian Neoplasms","volume":"380","author":"Harter","year":"2019","journal-title":"N. Engl. J. Med."}],"container-title":["Medicina"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1648-9144\/58\/5\/581\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T22:59:35Z","timestamp":1760137175000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1648-9144\/58\/5\/581"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,23]]},"references-count":46,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2022,5]]}},"alternative-id":["medicina58050581"],"URL":"https:\/\/doi.org\/10.3390\/medicina58050581","relation":{},"ISSN":["1648-9144"],"issn-type":[{"type":"electronic","value":"1648-9144"}],"subject":[],"published":{"date-parts":[[2022,4,23]]}}}