{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T11:15:41Z","timestamp":1784978141079,"version":"3.55.0"},"reference-count":26,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2022,4,25]],"date-time":"2022-04-25T00:00:00Z","timestamp":1650844800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Information about the impact of SARS-CoV-2 infection on pregnant women is still limited and raises challenges, even as publications are increasing rapidly. The aim of the present study was to determine the impact of SARS-CoV-2 infection on preterm birth pregnancies. We performed a prospective, observational study in a COVID-only hospital, which included 34 pregnant women with SARS-CoV-2 infection and preterm birth compared with a control group of 48 healthy women with preterm birth. The rate of cesarean delivery was 82% in the study group versus 6% for the control group. We observed a strong correlation between premature birth and the presence of COVID-19 symptoms (cough p = 0.029, fever p = 0.001, and chills p = 0.001). The risk for premature birth is correlated to a lower value of oxygen saturation (p = 0.001) and extensive radiologic pulmonary lesions (p = 0.025). The COVID-19 pregnant women with preterm delivery were older, and experienced an exacerbation of severe respiratory symptoms, decreased saturation of oxygen, increased inflammatory markers, severe pulmonary lesions and decreased lymphocytes.<\/jats:p>","DOI":"10.3390\/medicina58050587","type":"journal-article","created":{"date-parts":[[2022,4,25]],"date-time":"2022-04-25T21:16:28Z","timestamp":1650921388000},"page":"587","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["The Impact of SARS-CoV-2 Infection on Premature Birth\u2014Our Experience as COVID Center"],"prefix":"10.3390","volume":"58","author":[{"given":"Tina-Ioana","family":"Bobei","sequence":"first","affiliation":[{"name":"Department PhD, IOSUD, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 020021 Bucharest, Romania"},{"name":"\u201cBucur\u201d Maternity, Saint John Hospital, 012361 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bashar","family":"Haj Hamoud","sequence":"additional","affiliation":[{"name":"Department for Gynaecology, Obstetrics and Reproductive Medicine, Saarland University Hospital, Kirrberger Stra\u00dfe 100, Building 9, 66421 Homburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romina-Marina","family":"Sima","sequence":"additional","affiliation":[{"name":"\u201cBucur\u201d Maternity, Saint John Hospital, 012361 Bucharest, Romania"},{"name":"Department of Obstetrics and Gynecology, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5340-8929","authenticated-orcid":false,"given":"Gabriel-Petre","family":"Gorecki","sequence":"additional","affiliation":[{"name":"\u201cBucur\u201d Maternity, Saint John Hospital, 012361 Bucharest, Romania"},{"name":"Faculty of Medicine, Titu Maiorescu University, 040441 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mircea-Octavian","family":"Poenaru","sequence":"additional","affiliation":[{"name":"\u201cBucur\u201d Maternity, Saint John Hospital, 012361 Bucharest, Romania"},{"name":"Department of Obstetrics and Gynecology, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Octavian-Gabriel","family":"Olaru","sequence":"additional","affiliation":[{"name":"\u201cBucur\u201d Maternity, Saint John Hospital, 012361 Bucharest, Romania"},{"name":"Department of Obstetrics and Gynecology, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liana","family":"Ples","sequence":"additional","affiliation":[{"name":"\u201cBucur\u201d Maternity, Saint John Hospital, 012361 Bucharest, Romania"},{"name":"Department of Obstetrics and Gynecology, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,4,25]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization (2022, January 14). 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