{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T15:44:14Z","timestamp":1764603854585,"version":"build-2065373602"},"reference-count":70,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2022,4,27]],"date-time":"2022-04-27T00:00:00Z","timestamp":1651017600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Joimax GmbH","award":["76227"],"award-info":[{"award-number":["76227"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Introduction: Minimal-invasive instrumentation techniques have become a workhorse in spine surgery and require constant clinical evaluations. We sought to analyze patient-reported outcome measures (PROMs) and clinicopathological characteristics of thoracolumbar fracture stabilizations utilizing a minimal-invasive percutaneous dorsal screw-rod system. Methods: We included all patients with thoracolumbar spine fractures who underwent minimal-invasive percutaneous spine stabilization in our clinics since inception and who have at least 1 year of follow-up data. Clinical characteristics (length of hospital stay (LOS), operation time (OT), and complications), PROMs (preoperative (pre-op), 3-weeks postoperative (post-op), 1-year postoperative: eq5D, COMI, ODI, NRS back pain), and laboratory markers (leucocytes, c-reactive protein (CRP)) were analyzed, finding significant associations between these study variables and PROMs. Results: A total of 68 patients (m: 45.6%; f: 54.4%; mean age: 76.9 \u00b1 13.9) were included. The most common fracture types according to the AO classification were A3 (40.3%) and A4 (40.3%), followed by B2 (7.46%) and B1 (5.97%). The Median American Society of Anesthesiologists (ASA) score was 3 (range: 1\u20134). Stabilized levels ranged from TH4 to L5 (mean number of targeted levels: 4.25 \u00b1 1.4), with TH10-L2 (12\/68) and TH11-L3 (11\/68) being the most frequent site of surgery. Mean OT and LOS were 92.2 \u00b1 28.2 min and 14.3 \u00b1 6.9 days, respectively. We observed 9\/68 complications (13.2%), mostly involving screw misalignments and loosening. CRP increased from 24.9 \u00b1 33.3 pre-op to 34.8 \u00b1 29.9 post-op (p &lt; 0.001), whereas leucocyte counts remained stable. All PROMs showed a marked significant improvement for both 3-week and 1-year evaluations compared to the preoperative situation. Interestingly, we did not find an impact of OT, LOS, lab markers, complications, and other clinical characteristics on PROMs. Notably, a higher number of stabilized levels did not affect PROMs. Conclusions: Minimal-invasive stabilization of thoracolumbar fractures utilizing a dorsal percutaneous approach resulted in significant PROM outcome improvements, although we observed a complication rate of 13.2% for up to 1 year of follow-up. PROMs were not significantly associated with clinicopathological characteristics, technique-related variables, or the number of targeted levels.<\/jats:p>","DOI":"10.3390\/medicina58050606","type":"journal-article","created":{"date-parts":[[2022,4,27]],"date-time":"2022-04-27T22:20:20Z","timestamp":1651098020000},"page":"606","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["One-Year Clinical Outcomes of Minimal-Invasive Dorsal Percutaneous Fixation of Thoracolumbar Spine Fractures"],"prefix":"10.3390","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2298-3696","authenticated-orcid":false,"given":"Babak","family":"Saravi","sequence":"first","affiliation":[{"name":"Department of Orthopedics and Trauma Surgery, Medical Centre\u2014Albert-Ludwigs-University of Freiburg, Faculty of Medicine, Albert-Ludwigs-University of Freiburg, Hugstetterstrasse 55, 79106 Freiburg, Germany"},{"name":"Department of Spine Surgery, Loretto Hospital, 79100 Freiburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"\u00dclk\u00fcmen","sequence":"additional","affiliation":[{"name":"Department of Orthopedics and Trauma Surgery, Medical Centre\u2014Albert-Ludwigs-University of Freiburg, Faculty of Medicine, Albert-Ludwigs-University of Freiburg, Hugstetterstrasse 55, 79106 Freiburg, Germany"},{"name":"Department of Spine Surgery, Loretto Hospital, 79100 Freiburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8486-6412","authenticated-orcid":false,"given":"Sebastien","family":"Couillard-Despres","sequence":"additional","affiliation":[{"name":"Institute of Experimental Neuroregeneration, Spinal Cord Injury and Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University, 5020 Salzburg, Austria"},{"name":"Austrian Cluster for Tissue Regeneration, 1200 Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gernot","family":"Lang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics and Trauma Surgery, Medical Centre\u2014Albert-Ludwigs-University of Freiburg, Faculty of Medicine, Albert-Ludwigs-University of Freiburg, Hugstetterstrasse 55, 79106 Freiburg, Germany"},{"name":"Department of Spine Surgery, Loretto Hospital, 79100 Freiburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5618-9285","authenticated-orcid":false,"given":"Frank","family":"Hassel","sequence":"additional","affiliation":[{"name":"Department of Spine Surgery, Loretto Hospital, 79100 Freiburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,4,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.spinee.2012.10.041","article-title":"Management of Thoracolumbar Spine Fractures","volume":"14","author":"Wood","year":"2014","journal-title":"Spine J."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1177\/0954411917719740","article-title":"Biomechanical Analysis of the Thoracolumbar Spine under Physiological Loadings: Experimental Motion Data Corridors for Validation of Finite Element Models","volume":"231","author":"Couvertier","year":"2017","journal-title":"Proc. Inst. Mech. Eng. H"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"704","DOI":"10.14245\/ns.2142418.209","article-title":"Incidence and Epidemiology of Thoracolumbar Spine Fractures: WFNS Spine Committee Recommendations","volume":"18","author":"Zileli","year":"2021","journal-title":"Neurospine"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.annemergmed.2019.11.017","article-title":"Thoracic Spine Fracture in the Panscan Era","volume":"76","author":"Bizimungu","year":"2020","journal-title":"Ann. Emerg. Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.jor.2016.06.019","article-title":"The Epidemiology of Thoracolumbar Trauma: A Meta-Analysis","volume":"13","author":"Katsuura","year":"2016","journal-title":"J. Orthop."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"e12190","DOI":"10.1097\/MD.0000000000012190","article-title":"National Incidence of Traumatic Spinal Fractures in China: Data from China National Fracture Study","volume":"97","author":"Liu","year":"2018","journal-title":"Medicine"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"323","DOI":"10.3171\/2015.4.SPINE15194","article-title":"Incidence and Mechanism of Neurological Deficit after Thoracolumbar Fractures Sustained in Motor Vehicle Collisions","volume":"24","author":"Mukherjee","year":"2016","journal-title":"J. Neurosurg. Spine"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"77S","DOI":"10.1177\/2192568219827260","article-title":"AOSpine-Spine Trauma Classification System: The Value of Modifiers: A Narrative Review With Commentary on Evolving Descriptive Principles","volume":"9","author":"Divi","year":"2019","journal-title":"Glob. Spine J."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"155","DOI":"10.3171\/2019.1.SPINE18770","article-title":"Patient-Reported Outcomes in Spine Surgery: Past, Current, and Future Directions","volume":"31","author":"Finkelstein","year":"2019","journal-title":"J. Neurosurg. Spine"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"2184","DOI":"10.1007\/s00586-013-2738-0","article-title":"AO Spine Injury Classification System: A Revision Proposal for the Thoracic and Lumbar Spine","volume":"22","author":"Reinhold","year":"2013","journal-title":"Eur. Spine J."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"133","DOI":"10.4184\/asj.2015.9.1.133","article-title":"Treatment of Thoracolumbar Fracture","volume":"9","author":"Kim","year":"2015","journal-title":"Asian Spine J."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.jbspin.2004.08.006","article-title":"Minimal Access Spinal Technologies: State-of-the-Art, Indications, and Techniques","volume":"71","author":"Assaker","year":"2004","journal-title":"Jt. Bone Spine"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1097\/CORR.0000000000001086","article-title":"Classifications in Brief: AO Thoracolumbar Classification System","volume":"478","author":"Vu","year":"2020","journal-title":"Clin. Orthop. Relat. Res."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"2940","DOI":"10.1097\/00007632-200011150-00017","article-title":"The Oswestry Disability Index","volume":"25","author":"Fairbank","year":"2000","journal-title":"Spine"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"2638","DOI":"10.1007\/s00586-015-4292-4","article-title":"The Core Outcome Measures Index (COMI) Is a Responsive Instrument for Assessing the Outcome of Treatment for Adult Spinal Deformity","volume":"25","author":"Mannion","year":"2016","journal-title":"Eur. Spine J."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"S17","DOI":"10.1007\/s00586-005-1044-x","article-title":"Pain Assessment","volume":"15","author":"Haefeli","year":"2006","journal-title":"Eur. Spine J."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1186\/s12955-021-01792-y","article-title":"Evaluation of the EQ-5D-3L and 5L Versions in Low Back Pain Patients","volume":"19","author":"Garratt","year":"2021","journal-title":"Health Qual. Life Outcomes"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1179\/2042618613Y.0000000028","article-title":"Different Minimally Important Clinical Difference (MCID) Scores Lead to Different Clinical Prediction Rules for the Oswestry Disability Index for the Same Sample of Patients","volume":"21","author":"Schwind","year":"2013","journal-title":"J. Man. Manip. Ther."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1097\/MLR.0b013e3181c162a2","article-title":"Using Instrument-Defined Health State Transitions to Estimate Minimally Important Differences for Four Preference-Based Health-Related Quality of Life Instruments","volume":"48","author":"Luo","year":"2010","journal-title":"Med. Care"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.ejpain.2003.09.004","article-title":"Minimal Clinically Important Changes in Chronic Musculoskeletal Pain Intensity Measured on a Numerical Rating Scale","volume":"8","author":"Salaffi","year":"2004","journal-title":"Eur. J. Pain"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.tjem.2018.08.001","article-title":"User\u2019s Guide to Correlation Coefficients","volume":"18","author":"Akoglu","year":"2018","journal-title":"Turk. J. Emerg. Med."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1007\/s00586-008-0714-x","article-title":"Percutaneous Pedicle Screws Significantly Decrease Muscle Damage and Operative Time: Surgical Technique Makes a Difference!","volume":"17","author":"Dickerman","year":"2008","journal-title":"Eur. Spine J."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/s00113-010-1935-0","article-title":"Minimally invasive dorsal stabilization of the thoracolumbar spine","volume":"114","author":"Lendemans","year":"2011","journal-title":"Unfallchirurg"},{"key":"ref_24","first-page":"3","article-title":"Minimally Invasive Stabilization for Thoracolumbar Fractures","volume":"5","year":"2013","journal-title":"J. Spine"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"100806","DOI":"10.1016\/j.inat.2020.100806","article-title":"An Institutional Review of Percutaneous Stabilization versus Open Stabilization of Unstable Thoracolumbar Fractures","volume":"22","author":"Younus","year":"2020","journal-title":"Interdiscip. Neurosurg."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.clineuro.2015.05.016","article-title":"Percutaneous versus Open Pedicle Screw Fixation for Treatment of Thoracolumbar Fractures: Systematic Review and Meta-Analysis of Comparative Studies","volume":"135","author":"Phan","year":"2015","journal-title":"Clin. Neurol. Neurosurg."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1111\/j.1475-6773.2005.00486.x","article-title":"Variation in Hospital Length of Stay: Do Physicians Adapt Their Length of Stay Decisions to What Is Usual in the Hospital Where They Work?","volume":"41","author":"Westert","year":"2006","journal-title":"Health Serv. Res."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1177\/000313481608200324","article-title":"Association Between Insurance Status and Hospital Length of Stay Following Trauma","volume":"82","author":"Englum","year":"2016","journal-title":"Am. Surg."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"7","DOI":"10.2174\/1874325001004010007","article-title":"Treatment of Unstable Thoracolumbar Burst Fractures by Indirect Reduction and Posterior Stabilization: Short-Segment versus Long-Segment Stabilization","volume":"4","author":"Sapkas","year":"2010","journal-title":"Open Orthop. J."},{"key":"ref_30","first-page":"1750","article-title":"Comparison of Short-Segment versus Long-Segment Fixation for the Treatment of Thoracolumbar Burst Fracture: A Meta-Analysis","volume":"10","author":"Li","year":"2017","journal-title":"Int. J. Clin. Exp. Med."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00590-003-0110-5","article-title":"Effects of Two-Levels, Four-Levels, and Four-Levels plus Offset-Hook Posterior Fixation Techniques on Protecting the Surgical Correction of Unstable Thoracolumbar Vertebral Fractures: A Clinical Study","volume":"14","author":"Serin","year":"2004","journal-title":"Eur. J. Orthop. Surg. Traumatol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1007\/s00586-007-0310-5","article-title":"Treatment of Unstable Thoracolumbar Junction Burst Fractures with Short- or Long-Segment Posterior Fixation in Magerl Type a Fractures","volume":"16","author":"Altay","year":"2007","journal-title":"Eur. Spine J."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Wu, Y., Chen, C.-H., Tsuang, F.-Y., Lin, Y.-C., Chiang, C.-J., and Kuo, Y.-J. (2019). The Stability of Long-Segment and Short-Segment Fixation for Treating Severe Burst Fractures at the Thoracolumbar Junction in Osteoporotic Bone: A Finite Element Analysis. PLoS ONE, 14.","DOI":"10.1371\/journal.pone.0211676"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/1749-799X-4-28","article-title":"Two Levels above and One Level below Pedicle Screw Fixation for the Treatment of Unstable Thoracolumbar Fracture with Partial or Intact Neurology","volume":"4","author":"Modi","year":"2009","journal-title":"J. Orthop. Surg. Res."},{"key":"ref_35","first-page":"87","article-title":"Is It Possible to Save One Lumbar Segment in the Treatment of Thoracolumbar Fractures?","volume":"78","author":"Ugras","year":"2012","journal-title":"Acta Orthop. Belg."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1097\/BRS.0000000000003792","article-title":"Age as a Predictor for Complications and Patient-Reported Outcomes in Multilevel Transforaminal Lumbar Interbody Fusions: Analyses From the Michigan Spine Surgery Improvement Collaborative (MSSIC)","volume":"46","author":"Claus","year":"2021","journal-title":"Spine"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"29","DOI":"10.17116\/neiro201882329","article-title":"Prognostic models of the severity of acute dynamic pain on the first postoperative day and the likelihood of chronic postoperative pain in spine surgery","volume":"82","author":"Genov","year":"2018","journal-title":"Zhurnal Vopr. Neirokhirurgii Im. NN Burd."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Merali, Z.G., Witiw, C.D., Badhiwala, J.H., Wilson, J.R., and Fehlings, M.G. (2019). Using a Machine Learning Approach to Predict Outcome after Surgery for Degenerative Cervical Myelopathy. PLoS ONE, 14.","DOI":"10.1371\/journal.pone.0215133"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.3349\/ymj.2016.57.5.1214","article-title":"Surgical Outcome Predictor in Degenerative Lumbar Spinal Disease Based on Health Related Quality of Life Using Euro-Quality 5 Dimensions Analysis","volume":"57","author":"Lee","year":"2016","journal-title":"Yonsei Med. J."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"421","DOI":"10.36076\/ppj.2012\/15\/421","article-title":"Multivariate Prognostic Modeling of Persistent Pain Following Lumbar Discectomy","volume":"15","author":"Hegarty","year":"2012","journal-title":"Pain Physician"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1001\/jamasurg.2018.0072","article-title":"Development and Validation of a Prediction Model for Pain and Functional Outcomes After Lumbar Spine Surgery","volume":"153","author":"Khor","year":"2018","journal-title":"JAMA Surg."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"357","DOI":"10.3171\/2016.11.SPINE16526","article-title":"An Analysis from the Quality Outcomes Database, Part 1. Disability, Quality of Life, and Pain Outcomes Following Lumbar Spine Surgery: Predicting Likely Individual Patient Outcomes for Shared Decision-Making","volume":"27","author":"McGirt","year":"2017","journal-title":"J. Neurosurg. Spine"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1302\/0301-620X.95B1.28061","article-title":"The Effects of Age on Patient-Reported Outcome Measures in Total Knee Replacements","volume":"95-B","author":"Williams","year":"2013","journal-title":"Bone Jt. J."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1302\/0301-620X.89B7.19091","article-title":"The Role of Pain and Function in Determining Patient Satisfaction after Total Knee Replacement: Data from the national joint registry for england and wales","volume":"89-B","author":"Baker","year":"2007","journal-title":"J. Bone Jt. Surgery. Br. Vol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"E8","DOI":"10.3171\/2015.8.FOCUS15302","article-title":"Effect of Complications within 90 Days on Patient-Reported Outcomes 3 Months and 12 Months Following Elective Surgery for Lumbar Degenerative Disease","volume":"39","author":"Chotai","year":"2015","journal-title":"Neurosurg. Focus"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"2764","DOI":"10.1097\/BRS.0b013e31815a7644","article-title":"The Impact of Perioperative Complications on Clinical Outcome in Adult Deformity Surgery","volume":"32","author":"Glassman","year":"2007","journal-title":"Spine"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"382","DOI":"10.3171\/2016.12.SPINE16928","article-title":"Predictors of Extended Length of Stay, Discharge to Inpatient Rehab, and Hospital Readmission Following Elective Lumbar Spine Surgery: Introduction of the Carolina-Semmes Grading Scale","volume":"27","author":"McGirt","year":"2017","journal-title":"J. Neurosurg. Spine"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"82","DOI":"10.14444\/8011","article-title":"The Patient-Reported Outcome Measurement Information System (PROMIS) Better Reflects the Impact of Length of Stay and the Occurrence of Complications Within 90 Days Than Legacy Outcome Measures for Lumbar Degenerative Surgery","volume":"15","author":"Bortz","year":"2021","journal-title":"Int. J. Spine Surg."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Saravi, B., Lang, G., \u00dclk\u00fcmen, S., S\u00fcdkamp, N., and Hassel, F. (2021, January 29). Case-Matched Radiological and Clinical Outcome Evaluation of Interlaminar versus Microsurgical Decompression of Lumbar Spinal Stenosis. Proceedings of the Proce Deutscher Kongress f\u00fcr Orthop\u00e4die und Unfallchirurgie (DKOU 2021), Berlin, Germany.","DOI":"10.21203\/rs.3.rs-2094293\/v1"},{"key":"ref_50","first-page":"474685","article-title":"Usefulness of the Core Outcome Measures Index in Daily Clinical Practice for Assessing Patients with Degenerative Lumbar Disease","volume":"2012","author":"Molina","year":"2012","journal-title":"Adv. Orthop."},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Ohba, T., Ebata, S., and Haro, H. (2017). Comparison of Serum Markers for Muscle Damage, Surgical Blood Loss, Postoperative Recovery, and Surgical Site Pain after Extreme Lateral Interbody Fusion with Percutaneous Pedicle Screws or Traditional Open Posterior Lumbar Interbody Fusion. BMC Musculoskelet. Disord., 18.","DOI":"10.1186\/s12891-017-1775-y"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"545","DOI":"10.23937\/2378-3656\/1410001","article-title":"Validity of Creatine Kinase as an Indicator of Muscle Injury in Spine Surgery and Its Relation with Postoperative Pain","volume":"1","author":"Iglesias","year":"2014","journal-title":"Clin. Med. Rev. Case Rep."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1002\/jor.22911","article-title":"Comparison of Markers for Muscle Damage, Inflammation, and Pain Using Minimally Invasive Direct Anterior versus Direct Lateral Approach in Total Hip Arthroplasty: A Prospective, Randomized, Controlled Trial","volume":"33","author":"Mjaaland","year":"2015","journal-title":"J. Orthop. Res."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1007\/s00113-005-1037-6","article-title":"Percutaneous dorsal versus open instrumentation for fractures of the thoracolumbar border. A comparative, prospective study","volume":"109","author":"Grass","year":"2006","journal-title":"Unfallchirurg"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1007\/s00586-008-0652-7","article-title":"Comparison of Open versus Percutaneous Pedicle Screw Insertion in a Sheep Model","volume":"17","author":"Lehmann","year":"2008","journal-title":"Eur. Spine J."},{"key":"ref_56","first-page":"4091","article-title":"Comparison of the Effects of Minimally Invasive Percutaneous Pedicle Screws Osteosynthesis and Open Surgery on Repairing the Pain, Inflammation and Recovery of Thoracolumbar Vertebra Fracture","volume":"14","author":"Gong","year":"2017","journal-title":"Exp. Ther. Med."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1136\/jcp.36.2.203","article-title":"Early Time Course of the Acute Phase Protein Response in Man","volume":"36","author":"Colley","year":"1983","journal-title":"J. Clin. Pathol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1302\/0301-620X.80B5.0800909","article-title":"C-Reactive Protein Level after Total Hip and Total Knee Replacement","volume":"80","author":"White","year":"1998","journal-title":"J. Bone Jt. Surg. Br."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0009-8981(97)00071-5","article-title":"Incomplete or Absent Acute Phase Response in Some Postoperative Patients","volume":"264","author":"Bourguignat","year":"1997","journal-title":"Clin. Chim. Acta"},{"key":"ref_60","first-page":"86","article-title":"CRP Levels as a Measure of Surgical Trauma: A Comparison of Different General Surgical Procedures","volume":"39","author":"Brewster","year":"1994","journal-title":"J. R. Coll. Surg. Edinb."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1308\/003588408X285865","article-title":"Clinical Utility of Peri-Operative C-Reactive Protein Testing in General Surgery","volume":"90","author":"Cole","year":"2008","journal-title":"Ann. R. Coll. Surg. Engl."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"22","DOI":"10.5704\/MOJ.2011.005","article-title":"Minimally Invasive versus Conventional Open Surgery for Fixation of Spinal Fracture in Ankylosed Spine","volume":"14","author":"Chung","year":"2020","journal-title":"Malays. Orthop. J."},{"key":"ref_63","first-page":"62","article-title":"Muscular Changes after Minimally Invasive versus Open Spinal Stabilization of Thoracolumbar Fractures: A Literature Review","volume":"18","author":"Pishnamaz","year":"2018","journal-title":"J. Musculoskelet. Neuronal Interact"},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Ganse, B., Pishnamaz, M., Kobbe, P., Herren, C., Gradl-Dietsch, G., B\u00f6hle, F., Johannes, B., Kim, B.-S., Horst, K., and Knobe, M. (2017). Microcirculation in Open vs. Minimally Invasive Dorsal Stabilization of Thoracolumbar Fractures. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0188115"},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Erichsen, C.J., Heyde, C.-E., Josten, C., Gonschorek, O., Panzer, S., von R\u00fcden, C., and Spiegl, U.J. (2020). Percutaneous versus Open Posterior Stabilization in AOSpine Type A3 Thoracolumbar Fractures. BMC Musculoskelet. Disord., 21.","DOI":"10.1186\/s12891-020-3099-6"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/s00586-009-0989-6","article-title":"Minimally Invasive Percutaneous Fixation in the Treatment of Thoracic and Lumbar Spine Fractures","volume":"18","author":"Palmisani","year":"2009","journal-title":"Eur. Spine J."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"30","DOI":"10.17161\/kjm.v10i2.8649","article-title":"Functional Outcomes of Thoracolumbar Junction Spine Fractures","volume":"10","author":"Wall","year":"2017","journal-title":"Kans. J. Med."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1007\/s00113-012-2280-2","article-title":"Perkutane dorsale Instrumentierung der thorakolumbalen Wirbels\u00e4ule: Technik der geschlossenen Frakturreposition bei gleichzeitiger Dekompression des Spinalkanals","volume":"116","author":"Raible","year":"2013","journal-title":"Unfallchirurg"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s00113-010-1939-9","article-title":"Percutaneous techniques in the thoracic and lumbar spine","volume":"114","author":"Blattert","year":"2011","journal-title":"Unfallchirurg"},{"key":"ref_70","first-page":"137","article-title":"Percutaneous Pedicle Screw Fixation through the Pedicle of Fractured Vertebra in the Treatment of Type A Thoracolumbar Fractures Using Sextant System: An Analysis of 38 Cases","volume":"13","author":"Wang","year":"2010","journal-title":"Chin. J. Traumatol."}],"container-title":["Medicina"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1648-9144\/58\/5\/606\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T23:02:11Z","timestamp":1760137331000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1648-9144\/58\/5\/606"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,27]]},"references-count":70,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2022,5]]}},"alternative-id":["medicina58050606"],"URL":"https:\/\/doi.org\/10.3390\/medicina58050606","relation":{},"ISSN":["1648-9144"],"issn-type":[{"type":"electronic","value":"1648-9144"}],"subject":[],"published":{"date-parts":[[2022,4,27]]}}}