{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T12:45:41Z","timestamp":1766407541802,"version":"build-2065373602"},"reference-count":23,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2022,5,20]],"date-time":"2022-05-20T00:00:00Z","timestamp":1653004800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: Non-cystic manifestation of autosomal dominant polycystic kidney disease (ADPKD) is an important risk factor for cerebral aneurysms. In this report, we describe a rare spontaneous internal carotid artery (ICA) dissection in a patient with ADPKD. Observations: A 38-year-old woman with a history of ADPKD and acute myocardial infarction due to coronary artery dissection experienced severe spontaneous pain on the left side of her neck. Magnetic resonance imaging (MRI) revealed a severe left ICA stenosis localized at its origin. Carotid plaque MRI showed that the stenotic lesion was due to a subacute intramural hematoma. Close follow-up by an imaging study was performed under the diagnosis of spontaneous extracranial ICA dissection, and spontaneous regression of the intramural hematoma was observed uneventfully. Conclusions: When patients with a history of ADPKD present with severe neck pain, it is crucial to consider the possibility of a spontaneous ICA dissection. A carotid plaque MRI is beneficial in the differential diagnosis. Conservative management may benefit patients without ischemic symptoms.<\/jats:p>","DOI":"10.3390\/medicina58050679","type":"journal-article","created":{"date-parts":[[2022,5,20]],"date-time":"2022-05-20T13:56:12Z","timestamp":1653054972000},"page":"679","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["A Spontaneous Extracranial Internal Carotid Artery Dissection with Autosomal Dominant Polycystic Kidney Disease: A Case Report and Literature Review"],"prefix":"10.3390","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8778-2698","authenticated-orcid":false,"given":"Tsuyoshi","family":"Izumo","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki 852-8501, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuka","family":"Ogawa","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki 852-8501, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayaka","family":"Matsuo","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki 852-8501, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuaki","family":"Okamura","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki 852-8501, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryotaro","family":"Takahira","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki 852-8501, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3104-1919","authenticated-orcid":false,"given":"Eisaku","family":"Sadakata","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki 852-8501, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michiharu","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki 852-8501, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susumu","family":"Yamaguchi","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki 852-8501, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7685-6396","authenticated-orcid":false,"given":"Yohei","family":"Tateishi","sequence":"additional","affiliation":[{"name":"Department of Clinical Neuroscience and Neurology, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki 852-8501, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiro","family":"Baba","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki 852-8501, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7135-2220","authenticated-orcid":false,"given":"Yoichi","family":"Morofuji","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki 852-8501, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Hiu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki 852-8501, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeo","family":"Anda","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki 852-8501, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takayuki","family":"Matsuo","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki 852-8501, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,5,20]]},"reference":[{"key":"ref_1","unstructured":"Adam, M.P., Ardinger, H.H., Pagon, R.A., Wallace, S.E., Bean, L.J.H., Gripp, K.W., Mirzaa, G.M., and Amemiya, A. (2018). Polycystic Kidney Disease, Autosomal Dominant. GeneReviews\u00ae, University of Washington."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1053\/j.ackd.2010.01.003","article-title":"Extrarenal Manifestations of Autosomal Dominant Polycystic Kidney Disease","volume":"17","author":"Pirson","year":"2010","journal-title":"Adv. Chronic Kidney Dis."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1681\/ASN.V131269","article-title":"Management of Cerebral Aneurysms in Autosomal Dominant Polycystic Kidney Disease","volume":"13","author":"Pirson","year":"2002","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1016\/S0140-6736(07)60601-1","article-title":"Autosomal dominant polycystic kidney disease","volume":"369","author":"Torres","year":"2007","journal-title":"Lancet"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"2138","DOI":"10.1093\/ndt\/13.8.2138","article-title":"Spontaneous artery dissection: Is it part of the spectrum of autosomal dominant polycystic kidney disease?","volume":"13","author":"Bobrie","year":"1998","journal-title":"Nephrol. Dial. Transplant."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1159\/000350727","article-title":"Ruptured Cerebral Aneurysm and Acute Bilateral Carotid Artery Dissection in a Patient with Polycystic Kidney Disease and Polycystic Liver Disease","volume":"35","author":"Roth","year":"2013","journal-title":"Cerebrovasc. Dis."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1111\/nep.12042","article-title":"Horner syndrome in renal clinic: A woman with polycystic kidney disease and spontaneous carotid artery dissection","volume":"18","author":"Windpessl","year":"2013","journal-title":"Nephrology"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"e441","DOI":"10.1016\/j.jstrokecerebrovasdis.2014.05.028","article-title":"Vertebral Artery Dissection in Patients with Autosomal Dominant Polycystic Kidney Disease","volume":"23","author":"Kuroki","year":"2014","journal-title":"J. Stroke Cerebrovasc. Dis."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Chen, Z., Yuan, J., Li, H., Yuan, C., Yin, K., Liang, S., Li, P., and Wu, M. (2019). Isolated hypoglossal nerve palsy from internal carotid artery dissection related to PKD-1 gene mutation. BMC Neurol., 19.","DOI":"10.1186\/s12883-019-1477-1"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1212\/01.wnl.0000237341.30854.6a","article-title":"Gender differences in spontaneous cervical artery dissection","volume":"67","author":"Arnold","year":"2006","journal-title":"Neurology"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1212\/01.WNL.0000094325.95097.86","article-title":"Risk of stroke and recurrent dissection after a cervical artery dissection: A multicenter study","volume":"61","author":"Gauvrit","year":"2003","journal-title":"Neurology"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"e26670","DOI":"10.5812\/archneurosci.26670","article-title":"Cervical Artery Dissection: A Review of the Epidemiology, Pathophysiology, Treatment, and Outcome","volume":"2","author":"Blum","year":"2015","journal-title":"Arch. Neurosci."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1056\/NEJM200103223441206","article-title":"Spontaneous Dissection of the Carotid and Vertebral Arteries","volume":"344","author":"Schievink","year":"2001","journal-title":"N. Engl. J. Med."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1073\/pnas.040550097","article-title":"Polycystin 1 is required for the structural integrity of blood vessels","volume":"97","author":"Kim","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1038\/ng1076","article-title":"Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells","volume":"33","author":"Nauli","year":"2003","journal-title":"Nat. Genet."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/ng1097-179","article-title":"Perinatal lethality with kidney and pancreas defects in mice with a targetted Pkd1 mutation","volume":"17","author":"Lu","year":"1997","journal-title":"Nat. Genet."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1681\/ASN.V84616","article-title":"Vascular expression of polycystin","volume":"8","author":"Griffin","year":"1997","journal-title":"J. Am. Soc. Nephrol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"104992","DOI":"10.1016\/j.jstrokecerebrovasdis.2020.104992","article-title":"Cervical Artery Dissections with and without stroke, risk factors and prognosis: A Chilean prospective cohort","volume":"29","author":"Mazzon","year":"2020","journal-title":"J. Stroke Cerebrovasc. Dis."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1148\/rg.295085183","article-title":"High-Resolution MR Imaging of the Cervical Arterial Wall: What the Radiologist Needs to Know","volume":"29","author":"Oppenheim","year":"2009","journal-title":"RadioGraphics"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"265","DOI":"10.3174\/ajnr.A7384","article-title":"Proximal Region of Carotid Atherosclerotic Plaque Shows More Intraplaque Hemorrhage: The Plaque at Risk Study","volume":"43","author":"Crombag","year":"2022","journal-title":"AJNR Am. J. Neuroradiol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1001\/jamaneurol.2019.0072","article-title":"Antiplatelet Therapy vs Anticoagulation Therapy in Cervical Artery Dissection: The Cervical Artery Dissection in Stroke Study (CADISS) Randomized Clinical Trial Final Results","volume":"76","author":"Markus","year":"2019","journal-title":"JAMA Neurol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1212\/WNL.0000000000003617","article-title":"Prognosis of carotid dissecting aneurysms: Results from CADISS and a systematic review","volume":"88","author":"Larsson","year":"2017","journal-title":"Neurology."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"792321","DOI":"10.3389\/fneur.2021.792321","article-title":"Long-Term Sonographical Follow-Up of Arterial Stenosis Due to Spontaneous Cervical Artery Dissection","volume":"12","author":"Strunk","year":"2021","journal-title":"Front Neurol."}],"container-title":["Medicina"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1648-9144\/58\/5\/679\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T23:15:21Z","timestamp":1760138121000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1648-9144\/58\/5\/679"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,20]]},"references-count":23,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2022,5]]}},"alternative-id":["medicina58050679"],"URL":"https:\/\/doi.org\/10.3390\/medicina58050679","relation":{},"ISSN":["1648-9144"],"issn-type":[{"type":"electronic","value":"1648-9144"}],"subject":[],"published":{"date-parts":[[2022,5,20]]}}}