{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T13:31:34Z","timestamp":1791466294056,"version":"4.3.4"},"reference-count":41,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2022,5,26]],"date-time":"2022-05-26T00:00:00Z","timestamp":1653523200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: Neonatal mortality is a global public health issue, disproportionately affecting low- and middle-income nations. Although Romania is a high-income nation, according to the European Union\u2019s most recent demographic data, it had the second-highest infant death rate in 2019. Although significant progress has been made in the last three decades in lowering newborn mortality, more initiatives to accelerate progress are required to meet the 2030 Sustainable Development Goals (SDG) objective. Therefore, we aimed to develop an observational study to determine the influence of maternal factors on in-hospital neonatal intensive care unit admission and mortality in premature infants born in western Romania. While newborn mortality has decreased globally, the pace of decline is far less than what is desired. Materials and Methods: A retrospective study comprising 328 premature patients and 422 full-term newborns, was developed at a tertiary obstetrics and gynecology clinic in western Romania, comprising the period of the last 24 months before the COVID-19 pandemic and the first 24 months of the pandemic. Results: The following variables were identified as statistically significant risk factors for neonatal intensive care unit admission: age &gt; 35 years, OR = 1.59; twin births, OR = 1.14; low gestational age, OR = 1.66; preeclampsia, OR = 2.33; and peripartum infection, OR = 2.25. The same risk factors, with the exception of twin births, were significantly associated with in-hospital neonatal mortality. Except for a longer duration of maternal hospitalization and neonatal therapy with surfactant, steroids, and antibiotics, the COVID-19 pandemic did not cause significant differences in the evolution and outcomes of preterm newborns. Conclusions: The major maternal risk factors for NICU admission were advanced age, twin pregnancy, low gestational age, preeclampsia, and peripartum infection. Additionally, these characteristics contributed to a high likelihood of death, despite adequate access to medical care and advanced life support for the neonates. Understanding the causes of morbidity and death in neonates admitted to the neonatal intensive care unit enables better prioritization and planning of health services, resource reallocation, and care quality improvement.<\/jats:p>","DOI":"10.3390\/medicina58060709","type":"journal-article","created":{"date-parts":[[2022,5,28]],"date-time":"2022-05-28T01:40:45Z","timestamp":1653702045000},"page":"709","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["The Influence of Maternal Factors on Neonatal Intensive Care Unit Admission and In-Hospital Mortality in Premature Newborns from Western Romania: A Population-Based Study"],"prefix":"10.3390","volume":"58","author":[{"given":"Stelian-Gabriel","family":"Ilyes","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, \u201cVictor Babes\u201d University of Medicine and Pharmacy Timisoara, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8076-8885","authenticated-orcid":false,"given":"Veronica Daniela","family":"Chiriac","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, \u201cVictor Babes\u201d University of Medicine and Pharmacy Timisoara, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8354-9928","authenticated-orcid":false,"given":"Adrian","family":"Gluhovschi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, \u201cVictor Babes\u201d University of Medicine and Pharmacy Timisoara, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valcovici","family":"Mihaela","sequence":"additional","affiliation":[{"name":"Department of Cardiology, \u201cVictor Babes\u201d University of Medicine and Pharmacy Timisoara, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Dahma","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, \u201cVictor Babes\u201d University of Medicine and Pharmacy Timisoara, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adelina Geanina","family":"Mocanu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, \u201cVictor Babes\u201d University of Medicine and Pharmacy Timisoara, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4114-1582","authenticated-orcid":false,"given":"Radu","family":"Neamtu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, \u201cVictor Babes\u201d University of Medicine and Pharmacy Timisoara, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Silaghi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, \u201cVictor Babes\u201d University of Medicine and Pharmacy Timisoara, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Radu","sequence":"additional","affiliation":[{"name":"Department of General Surgery, \u201cVictor Babes\u201d University of Medicine and Pharmacy Timisoara, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1084-2714","authenticated-orcid":false,"given":"Elena","family":"Bernad","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, \u201cVictor Babes\u201d University of Medicine and Pharmacy Timisoara, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marius","family":"Craina","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, \u201cVictor Babes\u201d University of Medicine and Pharmacy Timisoara, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,5,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Bugelli, A., Borg\u00e8s Da Silva, R., Dowbor, L., and Sicotte, C. (2021). The Determinants of Infant Mortality in Brazil, 2010\u20132020: A Scoping Review. Int. J. Environ. Res. Public Health, 18.","DOI":"10.3390\/ijerph18126464"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1111\/1468-0009.12376","article-title":"Learning From History About Reducing Infant Mortality: Contrasting the Centrality of Structural Interventions to Early 20th-Century Successes in the United States to Their Neglect in Current Global Initiatives","volume":"97","author":"Bhatia","year":"2019","journal-title":"Milbank Q."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"595379","DOI":"10.3389\/fpubh.2020.595379","article-title":"Rate, Risk Factors, and Causes of Neonatal Deaths in Jordan: Analysis of Data From Jordan Stillbirth and Neonatal Surveillance System (JSANDS)","volume":"8","author":"Khader","year":"2020","journal-title":"Front. Public Health"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"19","DOI":"10.2471\/BLT.14.139790","article-title":"Neonatal cause-of-death estimates for the early and late neonatal periods for 194 countries: 2000\u20132013","volume":"93","author":"Oza","year":"2014","journal-title":"Bull. World Health Organ."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"752","DOI":"10.2471\/BLT.15.160945","article-title":"Neonatal mortality within 24 hours of birth in six low- and lower-middle-income countries","volume":"94","author":"Baqui","year":"2016","journal-title":"Bull. World Health Organ."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1055\/s-0032-1314885","article-title":"Neonatal death in low- to middle-income countries: A global network study","volume":"29","author":"McClure","year":"2012","journal-title":"Am. J. Perinatol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"605","DOI":"10.2471\/BLT.13.127464","article-title":"A prospective study of maternal, fetal and neonatal deaths in low- and middle-income countries","volume":"92","author":"Saleem","year":"2014","journal-title":"Bull. World Health Organ."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/S0140-6736(14)60236-1","article-title":"Maternal and neonatal tetanus","volume":"385","author":"Thwaites","year":"2015","journal-title":"Lancet"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Khan, A.A., Zahidie, A., and Rabbani, F. (2013). Interventions to reduce neonatal mortality from neonatal tetanus in low and middle income countries\u2014A systematic review. BMC Public Health, 13.","DOI":"10.1186\/1471-2458-13-322"},{"key":"ref_10","first-page":"69","article-title":"Overview of the pediatric healthcare system in Romania","volume":"55","author":"Pop","year":"2020","journal-title":"Turk Pediatri Ars."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1111\/ped.12219","article-title":"Mortality and morbidity of very preterm infants in Romania: How are we doing?","volume":"56","author":"Suciu","year":"2014","journal-title":"Pediatr. Int."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"e003618","DOI":"10.1136\/bmjgh-2020-003618","article-title":"Evidence-based interventions to reduce mortality among preterm and low-birthweight neonates in low-income and middle-income countries: A systematic review and meta-analysis","volume":"6","author":"Kleinhout","year":"2021","journal-title":"BMJ Glob. Health"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Taha, Z., Ali Hassan, A., Wikkeling-Scott, L., and Papandreou, D. (2020). Factors Associated with Preterm Birth and Low Birth Weight in Abu Dhabi, the United Arab Emirates. Int. J. Environ. Res. Public Health, 17.","DOI":"10.3390\/ijerph17041382"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Olack, B., Santos, N., Inziani, M., Moshi, V., Oyoo, P., Nalwa, G., OumaOtare, L.C., Walker, D., and Otieno, P.A. (2021). Causes of preterm and low birth weight neonatal mortality in a rural community in Kenya: Evidence from verbal and social autopsy. BMC Pregnancy Childbirth, 21.","DOI":"10.1186\/s12884-021-04012-z"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"e001462","DOI":"10.1136\/bmjgh-2019-001462","article-title":"Time trends and sociodemographic determinants of preterm births in pregnancy cohorts in Matlab, Bangladesh, 1990-2014","volume":"4","author":"Rahman","year":"2019","journal-title":"BMJ Glob. Health"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1038\/s41372-020-00912-8","article-title":"Temporal trends in preterm birth phenotypes by plurality: Black\u2013White disparity over half a century","volume":"41","author":"Dongarwar","year":"2021","journal-title":"J. Perinatol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.pedneo.2021.08.019","article-title":"Effects of COVID-19 pandemic period on neonatal mortality and morbidity","volume":"63","author":"Acar","year":"2022","journal-title":"Pediatr. Neonatol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1001\/jamapediatrics.2021.1050","article-title":"Maternal and Neonatal Morbidity and Mortality Among Pregnant Women with and without COVID-19 Infection: The INTERCOVID Multinational Cohort Study","volume":"175","author":"Villar","year":"2021","journal-title":"JAMA Pediatrics"},{"key":"ref_19","first-page":"e5789","article-title":"Frequency and Early Complications of Late Preterm Infants: A Descriptive Analysis from Two Secondary-care Hospitals of Karachi","volume":"11","author":"Khowaja","year":"2019","journal-title":"Cureus"},{"key":"ref_20","first-page":"100","article-title":"Premature delivery and the millennium development goal","volume":"5","author":"Nour","year":"2012","journal-title":"Rev. Obstet. Gynecol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"e17965","DOI":"10.5812\/ircmj.17965","article-title":"Long-term neurodevelopmental outcomes after preterm birth","volume":"16","author":"Soleimani","year":"2014","journal-title":"Iran. Red Crescent Med. J."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1038\/pr.2013.204","article-title":"Preterm birth\u2013associated neurodevelopmental impairment estimates at regional and global levels for 2010","volume":"74","author":"Blencowe","year":"2013","journal-title":"Pediatr. Res."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Younes, S., Samara, M., Al-Jurf, R., Nasrallah, G., Al-Obaidly, S., Salama, H., Olukade, T., Hammuda, S., Ismail, M., and Abdoh, G. (2021). Incidence, Risk Factors, and Outcomes of Preterm and Early Term Births: A Population-Based Register Study. Int. J. Environ. Res. Public Health, 18.","DOI":"10.3390\/ijerph18115865"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Bouvier, D., Forest, J.-C., Blanchon, L., Bujold, E., Pereira, B., Bernard, N., Gallot, D., Sapin, V., and Gigu\u00e8re, Y. (2019). Risk Factors and Outcomes of Preterm Premature Rupture of Membranes in a Cohort of 6968 Pregnant Women Prospectively Recruited. J. Clin. Med., 8.","DOI":"10.3390\/jcm8111987"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"6047","DOI":"10.1016\/j.vaccine.2016.03.045","article-title":"Preterm birth: Case definition & guidelines for data collection, analysis, and presentation of immunisation safety data","volume":"34","author":"Quinn","year":"2016","journal-title":"Vaccine"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"6027","DOI":"10.1016\/j.vaccine.2016.03.040","article-title":"Neonatal death: Case definition & guidelines for data collection, analysis, and presentation of immunization safety data","volume":"34","author":"Pathirana","year":"2016","journal-title":"Vaccine"},{"key":"ref_27","first-page":"241","article-title":"High-risk pregnancy","volume":"53","author":"Holness","year":"2018","journal-title":"Nurs. Clin."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Woodd, S.L., Montoya, A., Barreix, M., Pi, L., Calvert, C., Rehman, A.M., Chou, D., and Campbell, O.M.R. (2019). Incidence of maternal peripartum infection: A systematic review and meta-analysis. PLoS Med., 16.","DOI":"10.1371\/journal.pmed.1002984"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1038\/pr.2018.1","article-title":"Causes and circumstances of death in a neonatal unit over 20 years","volume":"83","author":"Michel","year":"2018","journal-title":"Pediatr. Res."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Alanazi, A.F.R., Naser, A.Y., Pakan, P., Alanazi, A.F., Alanazi, A.A.A., Alsairafi, Z.K., and Alsaleh, F.M. (2021). Trends of Hospital Admissions Due to Congenital Anomalies in England and Wales between 1999 and 2019: An Ecological Study. Int. J. Environ. Res. Public Health, 18.","DOI":"10.3390\/ijerph182211808"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"4760","DOI":"10.3390\/nu5114760","article-title":"Folate Deficiency and Folic Acid Supplementation: The Prevention of Neural-Tube Defects and Congenital Heart Defects","volume":"5","author":"Czeizel","year":"2013","journal-title":"Nutrients"},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Dempsey, T., Nguyen, H.L., Nguyen, H.T., Bui, X.A., Pham, P.T.T., Nguyen, T.K., Cavallin, F., Trevisanuto, D., H\u00f6\u00f6k, S.M., and Pejovic, N. (2022). Incidence of Intrapartum-Related Events at the Largest Obstetric Hospital in Hanoi, Vietnam: A Retrospective Study. Children, 9.","DOI":"10.3390\/children9030321"},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"\u0162arc\u0103, E., Ro\u0219u, S.T., Cojocaru, E., Trandafir, L., Luca, A., Rusu, D., and \u0162arc\u0103, V. (2021). Socio-Epidemiological Factors with Negative Impact on Infant Morbidity, Mortality Rates, and the Occurrence of Birth Defects. Healthcare, 9.","DOI":"10.3390\/healthcare9040384"},{"key":"ref_34","unstructured":"Black, R.E., Laxminarayan, R., Temmerman, M., and Walker, N. (2022, March 10). Interventions to Reduce Maternal and Newborn Morbidity and Mortality, Reproductive, Maternal, Newborn, and Child Health: Disease Control Priorities, Available online: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK361904\/."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/reprodmed3010001","article-title":"Early Identification of the Maternal, Placental and Fetal Dialog in Gestational Diabetes and Its Prevention","volume":"3","author":"Naeh","year":"2022","journal-title":"Reprod. Med."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Cupen, K., Barran, A., Singh, V., and Dialsingh, I. (2017). Risk Factors Associated with Preterm Neonatal Mortality: A Case Study Using Data from Mt. Hope Women\u2019s Hospital in Trinidad and Tobago. Children, 4.","DOI":"10.3390\/children4120108"},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Dagher, R.K., and Linares, D.E. (2022). A Critical Review on the Complex Interplay between Social Determinants of Health and Maternal and Infant Mortality. Children, 9.","DOI":"10.3390\/children9030394"},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Lewandowska, M. (2021). Maternal Obesity and Risk of Low Birth Weight, Fetal Growth Restriction, and Macrosomia: Multiple Analyses. Nutrients, 13.","DOI":"10.3390\/nu13041213"},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"S\u0142abuszewska-J\u00f3\u017awiak, A., Szyma\u0144ski, J.K., Ciebiera, M., Sarecka-Hujar, B., and Jakiel, G. (2020). Pediatrics Consequences of Caesarean Section\u2014A Systematic Review and Meta-Analysis. Int. J. Environ. Res. Public Health, 17.","DOI":"10.3390\/ijerph17218031"},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Bizzego, A., Gabrieli, G., Bornstein, M.H., Deater-Deckard, K., Lansford, J.E., Bradley, R.H., Costa, M., and Esposito, G. (2021). Predictors of Contemporary under-5 Child Mortality in Low- and Middle-Income Countries: A Machine Learning Approach. Int. J. Environ. Res. Public Health, 18.","DOI":"10.3390\/ijerph18031315"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"18","DOI":"10.3961\/jpmph.16.087","article-title":"Distribution and Determinants of Low Birth Weight in Developing Countries","volume":"50","author":"Mahumud","year":"2017","journal-title":"J. Prev. Med. Public Health"}],"container-title":["Medicina"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1648-9144\/58\/6\/709\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T23:19:01Z","timestamp":1760138341000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1648-9144\/58\/6\/709"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,26]]},"references-count":41,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2022,6]]}},"alternative-id":["medicina58060709"],"URL":"https:\/\/doi.org\/10.3390\/medicina58060709","relation":{},"ISSN":["1648-9144"],"issn-type":[{"value":"1648-9144","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,26]]}}}