{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T18:27:05Z","timestamp":1793384825930,"version":"4.5.0"},"reference-count":32,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2022,6,15]],"date-time":"2022-06-15T00:00:00Z","timestamp":1655251200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007783","name":"MEB research fund of Hanyang University","doi-asserted-by":"publisher","award":["HY-202100000002866"],"award-info":[{"award-number":["HY-202100000002866"]}],"id":[{"id":"10.13039\/501100007783","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and objectives: This study aims to evaluate the usefulness of the quantitative pupillary light reflex as a prognostic tool for neurological outcomes in post-cardiac arrest patients treated with targeted temperature management (TTM). Material and Methods: We systematically searched MEDLINE, EMBASE, and the Cochrane Library (search date: 9 July 2021) for studies on post-cardiac arrest patients treated with TTM that had measured the percent constriction of pupillary light reflex (%PLR) with quantitative pupillometry as well as assessed the neurological outcome. For an assessment of the methodological quality of the included studies, two authors utilized the prognosis study tool independently. Results: A total of 618 patients from four studies were included in this study. Standardized mean differences (SMDs) were calculated to compare patients with good or poor neurological outcomes. A higher %PLR measured at 0\u201324 h after hospital admission was related to good neurological outcomes at 3 months in post-cardiac arrest patients treated with TTM (SMD 0.87; 95% confidence interval 0.70\u20131.05; I2 = 0%). A higher %PLR amplitude measured at 24\u201348 h after hospital admission was also associated with a good neurological outcome at 3 months in post-cardiac arrest patients treated with TTM, but with high heterogeneity (standardized mean difference 0.86; 95% confidence interval 0.40\u20131.32; I2 = 70%). The evidence supporting these findings was of poor quality. For poor neurological outcome, the prognosis accuracy of %PLR was 9.19 (pooled diagnostic odds ratio, I2 = 0%) and 0.75 (area under the curve). Conclusions: The present meta-analysis could not reveal that change of %PLR was an effective tool in predicting neurological outcomes for post-cardiac arrest patients treated with TTM owing to a paucity of included studies and the poor quality of the evidence.<\/jats:p>","DOI":"10.3390\/medicina58060804","type":"journal-article","created":{"date-parts":[[2022,6,16]],"date-time":"2022-06-16T03:01:22Z","timestamp":1655348482000},"page":"804","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Efficacy of Quantitative Pupillary Light Reflex for Predicting Neurological Outcomes in Patients Treated with Targeted Temperature Management after Cardiac Arrest: A Systematic Review and Meta-Analysis"],"prefix":"10.3390","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2446-4497","authenticated-orcid":false,"given":"Jae-Guk","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine, College of Medicine, Hallym University, Chuncheon 24253, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3203-1672","authenticated-orcid":false,"given":"Hyungoo","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Hanyang University College of Medicine, Seoul 04763, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1045-413X","authenticated-orcid":false,"given":"Tae-Ho","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Hanyang University College of Medicine, Seoul 04763, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7055-2500","authenticated-orcid":false,"given":"Wonhee","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, College of Medicine, Hallym University, Chuncheon 24253, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7648-924X","authenticated-orcid":false,"given":"Youngsuk","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, College of Medicine, Hallym University, Chuncheon 24253, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2141-3483","authenticated-orcid":false,"given":"Bo-Hyoung","family":"Jang","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine, College of Korean Medicine, Kyung Hee University, Seoul 02447, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyu-Sun","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Hanyang University College of Medicine, Seoul 04763, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6826-8490","authenticated-orcid":false,"given":"Min-Kyun","family":"Na","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Hanyang University College of Medicine, Seoul 04763, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1813-1098","authenticated-orcid":false,"given":"Chiwon","family":"Ahn","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, College of Medicine, Chung-Ang University, Seoul 06974, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juncheol","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Hanyang University College of Medicine, Seoul 04763, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,6,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.1097\/CCM.0000000000000335","article-title":"Predicting neurologic outcome after targeted temperature management for cardiac arrest: Systematic review and meta-analysis","volume":"42","author":"Golan","year":"2014","journal-title":"Crit. 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