{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T04:08:34Z","timestamp":1762056514401,"version":"build-2065373602"},"reference-count":31,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2022,6,17]],"date-time":"2022-06-17T00:00:00Z","timestamp":1655424000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"World Bank, the Ministry of Digital Development, Innovation and Aerospace Industry of the Republic of Kazakhstan and the Government of the Republic of Kazakhstan","award":["APP-SSG-17\/0236F"],"award-info":[{"award-number":["APP-SSG-17\/0236F"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: Homogeneous and xenogenic bioengineering structures are actively used as wound coatings in treatment of burns and have already shown their effectiveness. Nevertheless, the disadvantage of such dressings is their high cost. This issue is particularly challenging for developing countries in which the incidence of burns is the highest one. With such needs taken into account, the research team developed and clinically tested a new wound coating based on decellularized bovine peritoneum (DBP). Materials and Methods: A multicenter randomized clinical trial was conducted to evaluate DBP. The following variables were considered in the research study: the number of inpatient days, the number of dressing changes, the level of pain experienced during dressing changes, and the condition of wounds at the time of the follow-up examination. Results: The research involved 68 participants. It was found that the patients who were treated with a DBP experienced less pain with less changes of dressings. However, the number of inpatient days and wound healing failed to demonstrate statistically significant difference compared to the control group. Conclusions: In the given research, DBP showed efficacy in improving patients\u2019 quality of life by reducing pain and the number of dressings\u2019 changes. However, when comparing this research study with the studies of other animal-derived wound coverings, there were a number of differences and limitations in the parameters. Thus, the results requires further study for a greater comparability of data. Given the above, we expect that DBP will become an inexpensive and effective treatment for burns in developing countries.<\/jats:p>","DOI":"10.3390\/medicina58060819","type":"journal-article","created":{"date-parts":[[2022,6,17]],"date-time":"2022-06-17T11:45:44Z","timestamp":1655466344000},"page":"819","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Therapeutic Treatment of 2A Grade Burns with Decellularized Bovine Peritoneum as a Xenograft: Multicenter Randomized Clinical Trial"],"prefix":"10.3390","volume":"58","author":[{"given":"Berik","family":"Tuleubayev","sequence":"first","affiliation":[{"name":"Surgical Diseases Department, Karaganda Medical University, 40 Gogol str., Karaganda 100000, Kazakhstan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5029-5255","authenticated-orcid":false,"given":"Vyacheslav","family":"Ogay","sequence":"additional","affiliation":[{"name":"Stem Cells Laboratory, National Center for Biotechnology, 13\/5 Korgalzhyn Ave., Nur-Sultan 01000, Kazakhstan"},{"name":"\u201cX-Matrix\u201d LLP, 13\/5 Korgalzhyn Ave., Nur-Sultan 01000, Kazakhstan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2311-7861","authenticated-orcid":false,"given":"Baurzhan","family":"Anapiya","sequence":"additional","affiliation":[{"name":"Surgical Diseases Department, Karaganda Medical University, 40 Gogol str., Karaganda 100000, Kazakhstan"},{"name":"Department of Multidisciplinary Surgery, National Research Oncology Centre, 3 Kerei-Zhanibek Khandar str., Nur-Sultan 01000, Kazakhstan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Assylbek","family":"Zhylkibayev","sequence":"additional","affiliation":[{"name":"Department of Optometry and Vision Science, The University of Alabama at Birmingham, Birmingham, AL 35294, USA"},{"name":"Laboratory of Applied Genetics, National Center for Biotechnology, Nur-Sultan 01000, Kazakhstan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9551-5354","authenticated-orcid":false,"given":"Dina","family":"Saginova","sequence":"additional","affiliation":[{"name":"National Scientific Center of Traumatology and Orthopedics Named after Academician N.D. Batpenov, 15a Abylay khan Ave., Nur-Sultan 01000, Kazakhstan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8620-2196","authenticated-orcid":false,"given":"Amina","family":"Koshanova","sequence":"additional","affiliation":[{"name":"Surgical Diseases Department, Karaganda Medical University, 40 Gogol str., Karaganda 100000, Kazakhstan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yerkin-Dauir","family":"Kurmangaliyev","sequence":"additional","affiliation":[{"name":"Multidisciplinary Hospital named after Professor H.Zh. Makazhanov, 5\/3 Mukanov str., Karaganda 100000, Kazakhstan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kanat","family":"Tezekbayev","sequence":"additional","affiliation":[{"name":"Department of Traumatology and Orthopedics, Kazakh National Medical University, 220 Papanina str., Almaty 050000, Kazakhstan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nurzhan","family":"Bikonurov","sequence":"additional","affiliation":[{"name":"Burn Department, Municipal Clinical Hospital \u21164, Almaty 050000, Kazakhstan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kabylbek","family":"Abugaliyev","sequence":"additional","affiliation":[{"name":"\u201cX-Matrix\u201d LLP, 13\/5 Korgalzhyn Ave., Nur-Sultan 01000, Kazakhstan"},{"name":"Department of Multidisciplinary Surgery, National Research Oncology Centre, 3 Kerei-Zhanibek Khandar str., Nur-Sultan 01000, Kazakhstan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,6,17]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization (2022, April 14). 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