{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T22:17:47Z","timestamp":1769638667593,"version":"3.49.0"},"reference-count":22,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2022,7,2]],"date-time":"2022-07-02T00:00:00Z","timestamp":1656720000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: Subclinical atherosclerosis, reflected by abnormal carotid intima\u2013media thickness (cIMT), is pervasive among chronic kidney disease patients on chronic renal replacement therapy (RRT), being mostly influenced by uremia-related rather than traditional risk factors. Materials and Methods: In this pilot study, we measured circulating levels of Omentin-1, a recently discovered adipokine with strong anti-atherogenic properties, in a heterogeneous cohort of 77 asymptomatic RRT individuals (40 chronic kidney transplant recipients, Ktx; and 37 chronic hemodialysis patients, HD) and in 30 age-matched controls. Results: Omentin-1 was increased in RRT individuals as compared with controls (p = 0.03). When stratifying for renal replacement modality, we found Ktx patients to have significantly lower Omentin-1 than HD patients (p = 0.01). Lower Omentin-1 levels were also found among RRT individuals with pathological cIMT (168.7 [51.1\u2013457.8] vs. 474.9 [197.2\u20131432.1]; p = 0.004). Our multivariate correlations analysis revealed Omentin-1 as the most robust independent predictor of carotid atherosclerosis (\u03b2-0.687; p = 0.03), even more than total cholesterol, diastolic BP and age, and this adipokine was at the crossroad of a complex interplay with sustained inflammation (high CRP and ferritin) and hyperphosphatemia in predicting higher cIMT values. Conclusion: The findings reported extend to renal patients with advanced disease, with the possible involvement of Omentin-1 in the pathogenesis of atherosclerosis. This may set the stage for future interventional studies of Omentin-1 replacement to retard atherosclerosis progression, as it is currently being investigated in other disease settings.<\/jats:p>","DOI":"10.3390\/medicina58070890","type":"journal-article","created":{"date-parts":[[2022,7,3]],"date-time":"2022-07-03T22:50:46Z","timestamp":1656888646000},"page":"890","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Circulating Omentin-1, Sustained Inflammation and Hyperphosphatemia at the Interface of Subclinical Atherosclerosis in Chronic Kidney Disease Patients on Chronic Renal Replacement Therapy"],"prefix":"10.3390","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3032-245X","authenticated-orcid":false,"given":"Davide","family":"Bolignano","sequence":"first","affiliation":[{"name":"Renal Unit, \u201cMagna Graecia\u201d University, 88100 Catanzaro, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4192-3891","authenticated-orcid":false,"given":"Marta","family":"Greco","sequence":"additional","affiliation":[{"name":"Clinical Pathology Lab, \u201cMagna Graecia\u201d University, 88100 Catanzaro, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valentina","family":"Arcidiacono","sequence":"additional","affiliation":[{"name":"Renal Unit, \u201cMagna Graecia\u201d University, 88100 Catanzaro, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierangela","family":"Presta","sequence":"additional","affiliation":[{"name":"Renal Unit, \u201cMagna Graecia\u201d University, 88100 Catanzaro, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfredo","family":"Caglioti","sequence":"additional","affiliation":[{"name":"Renal Unit, \u201cMagna Graecia\u201d University, 88100 Catanzaro, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7974-3792","authenticated-orcid":false,"given":"Michele","family":"Andreucci","sequence":"additional","affiliation":[{"name":"Renal Unit, \u201cMagna Graecia\u201d University, 88100 Catanzaro, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Dragone","sequence":"additional","affiliation":[{"name":"Clinical Pathology Lab, \u201cMagna Graecia\u201d University, 88100 Catanzaro, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9536-5736","authenticated-orcid":false,"given":"Daniela Patrizia","family":"Foti","sequence":"additional","affiliation":[{"name":"Clinical Pathology Lab, \u201cMagna Graecia\u201d University, 88100 Catanzaro, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8000-0681","authenticated-orcid":false,"given":"Giuseppe","family":"Coppolino","sequence":"additional","affiliation":[{"name":"Renal Unit, \u201cMagna Graecia\u201d University, 88100 Catanzaro, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,7,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"299","DOI":"10.5551\/jat.10454","article-title":"Chronic kidney disease, dyslipidemia, and atherosclerosis","volume":"19","author":"Shoji","year":"2012","journal-title":"J. Atheroscler. Thromb."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1046\/j.1523-1755.2001.059002407.x","article-title":"End-stage renal disease, atherosclerosis, and cardiovascular mortality: Is C-reactive protein the missing link?","volume":"59","author":"Arici","year":"2001","journal-title":"Kidney Int."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1002\/cphy.c160043","article-title":"Adipose Tissue-Derived Omentin-1 Function and Regulation","volume":"7","author":"Watanabe","year":"2017","journal-title":"Compr. Physiol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1080\/14728222.2022.2037556","article-title":"Omentin-1: A newly discovered warrior against metabolic related diseases","volume":"26","author":"Zhao","year":"2022","journal-title":"Expert Opin. Targets"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1093\/ckj\/sfab189","article-title":"Circulating Omentin-1 levels and altered iron balance in chronic haemodialysis patients","volume":"15","author":"Bolignano","year":"2022","journal-title":"Clin. Kidney J."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1007\/s11255-016-1275-2","article-title":"Soluble intracellular adhesion molecule-1 and omentin-1 as potential biomarkers of subclinical atherosclerosis in hemodialysis patients","volume":"48","author":"Kocijancic","year":"2016","journal-title":"Int. Urol. Nephrol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.diabres.2015.06.008","article-title":"Serum omentin-1 levels as a possible risk factor of mortality in patients with diabetes on haemodialysis","volume":"110","author":"Kocijancic","year":"2015","journal-title":"Diabetes Res. Clin. Pract."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1016\/j.echo.2020.04.021","article-title":"Recommendations for the Assessment of Carotid Arterial Plaque by Ultrasound for the Characterization of Atherosclerosis and Evaluation of Cardiovascular Risk: From the American Society of Echocardiography","volume":"33","author":"Johri","year":"2020","journal-title":"J. Am. Soc. Echocardiogr. Off. Publ. Am. Soc. Echocardiogr."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1055\/s-0034-1375674","article-title":"Serum omentin-1 levels in diabetic and nondiabetic patients with chronic kidney disease","volume":"122","author":"Tekce","year":"2014","journal-title":"Exp. Clin. Endocrinol. Diabetes"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.3109\/0886022X.2013.817256","article-title":"Serum omentin-1, inflammation and carotid atherosclerosis in patients with non-diabetic chronic kidney disease","volume":"35","author":"Sengul","year":"2013","journal-title":"Ren. Fail"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1186\/s12933-020-01151-z","article-title":"Association between omentin-1 and major cardiovascular events after lower extremity endovascular revascularization in diabetic patients: A prospective cohort study","volume":"19","author":"Biscetti","year":"2020","journal-title":"Cardiovasc. Diabetol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.cca.2020.03.007","article-title":"Serum omentin-1 and risk of one-year mortality in patients with ischemic stroke","volume":"505","author":"Xu","year":"2020","journal-title":"Clin. Chim. Acta"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1159\/000487396","article-title":"Usefulness of Serum Omentin-1 Levels for the Prediction of Adverse Cardiac Events in Patients with Hypertrophic Cardiomyopathy","volume":"27","author":"Yildiz","year":"2018","journal-title":"Med. Princ. Pract."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.diabres.2011.03.001","article-title":"Omentin-1 is associated with carotid atherosclerosis in patients with metabolic syndrome","volume":"93","author":"Liu","year":"2011","journal-title":"Diabetes Res. Clin. Pract."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1186\/s12933-019-0973-3","article-title":"Plasma omentin levels are inversely associated with atherosclerosis in type 2 diabetes patients with increased plasma adiponectin levels: A cross-sectional study","volume":"18","author":"Nishimura","year":"2019","journal-title":"Cardiovasc. Diabetol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"155364","DOI":"10.1016\/j.cyto.2020.155364","article-title":"Omentin-1 and vaspin serum levels in patients with pre-clinical carotid atherosclerosis and the effect of statin therapy on them","volume":"138","author":"Kadoglou","year":"2021","journal-title":"Cytokine"},{"key":"ref_17","first-page":"e17347","article-title":"Association Between Coronary Artery Disease and Plasma Omentin-1 Levels","volume":"13","author":"Bai","year":"2021","journal-title":"Cureus"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1016\/j.jcmg.2013.11.014","article-title":"Carotid intima-media thickness and plaque in cardiovascular risk assessment","volume":"7","author":"Naqvi","year":"2014","journal-title":"JACC Cardiovasc. Imaging"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1111\/j.1432-2277.2010.01159.x","article-title":"Risk factors for cardiovascular disease in renal transplant recipients and strategies to minimize risk","volume":"23","author":"Liefeldt","year":"2010","journal-title":"Transpl. Int."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1159\/000067852","article-title":"Inflammation and atherosclerosis in end-stage renal disease","volume":"21","author":"Zoccali","year":"2003","journal-title":"Blood Purif."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1938","DOI":"10.1161\/ATVBAHA.119.312705","article-title":"Atherosclerosis in Chronic Kidney Disease: More, Less, or Just Different?","volume":"39","author":"Valdivielso","year":"2019","journal-title":"Arter. Thromb. Vasc. Biol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/s41413-018-0012-0","article-title":"Omentin-1 prevents inflammation-induced osteoporosis by downregulating the pro-inflammatory cytokines","volume":"6","author":"Rao","year":"2018","journal-title":"Bone Res."}],"container-title":["Medicina"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1648-9144\/58\/7\/890\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T23:42:04Z","timestamp":1760139724000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1648-9144\/58\/7\/890"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,2]]},"references-count":22,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2022,7]]}},"alternative-id":["medicina58070890"],"URL":"https:\/\/doi.org\/10.3390\/medicina58070890","relation":{},"ISSN":["1648-9144"],"issn-type":[{"value":"1648-9144","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,2]]}}}