{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T16:59:20Z","timestamp":1782233960729,"version":"3.54.5"},"reference-count":12,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2022,7,6]],"date-time":"2022-07-06T00:00:00Z","timestamp":1657065600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Oncocytic adrenal cortical neoplasms are rare cases and are divided into oncocytoma, oncocytic neoplasms of uncertain malignant potential and oncocytic adrenal cortical carcinomas, based on the Lin\u2013Weiss\u2013Bisceglia (LWB) histological system adopted in the current World Health Organization (WHO). We reported a 42-year-old female diagnosed with an oncocytic neoplasm of uncertain malignant potential initially, which turned out to be a carcinoma owing to distant metastasis to the scalp and lung. To our knowledge, this is the first published case of oncocytic adrenal cortical carcinoma with scalp metastasis. This case also highlights the limitation of the current diagnostic algorithm and emphasizes the importance of two parameters (PHH3 and Ki-67) for determining the malignant potential of oncocytic adrenal cortical neoplasms.<\/jats:p>","DOI":"10.3390\/medicina58070900","type":"journal-article","created":{"date-parts":[[2022,7,6]],"date-time":"2022-07-06T09:41:10Z","timestamp":1657100470000},"page":"900","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["A Case of Oncocytic Adrenal Cortical Neoplasm with Uncertain Malignant Potential Turned Out to Be Oncocytic Adrenal Cortical Carcinoma with Distant Metastasis: Could Pathology Do Better Initially?"],"prefix":"10.3390","volume":"58","author":[{"given":"Chien-Peng","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Pathology, Tri-Service General Hospital, National Defense Medical Center, Taibei 11490, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Shen","family":"Dai","sequence":"additional","affiliation":[{"name":"Division of Hematology, Tri-Service General Hospital, National Defense Medical Center, Taibei 11490, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0107-4450","authenticated-orcid":false,"given":"Chien-Chang","family":"Kao","sequence":"additional","affiliation":[{"name":"Division of Genitourinary, Tri-Service General Hospital, National Defense Medical Center, Taibei 11490, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1085-9014","authenticated-orcid":false,"given":"Wen-Chiuan","family":"Tsai","sequence":"additional","affiliation":[{"name":"Department of Pathology, Tri-Service General Hospital, National Defense Medical Center, Taibei 11490, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0693-5056","authenticated-orcid":false,"given":"Cheng-Ping","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Pathology, Tri-Service General Hospital, National Defense Medical Center, Taibei 11490, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,7,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/j.humpath.2010.08.010","article-title":"Oncocytic adrenocortical neoplasms\u2014A clinicopathologic study of 13 new cases emphasizing the importance of their recognition","volume":"42","author":"Wong","year":"2011","journal-title":"Hum. 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Oncol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1097\/PAS.0b013e31824517d9","article-title":"Oncocytic adrenal cortical carcinosarcoma with pleomorphic rhabdomyosarcomatous metastases","volume":"36","author":"Thway","year":"2012","journal-title":"Am. J. Surg. Pathol."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Sistla, S., Krishnaraj, B., Shankar, G., Ruparelia, J., Giri, P., and Hanuman, S.B. (2020). Oncocytic Variant of Adrenocortical Carcinoma: Case Report of a Rare Malignancy. Surg. Case Rep., 1\u20134.","DOI":"10.31487\/j.SCR.2020.06.06"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1016\/j.path.2019.08.005","article-title":"A Diagnostic Approach to Adrenocortical Tumors","volume":"12","author":"Hodgson","year":"2019","journal-title":"Surg. Pathol. Clin."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"e234591","DOI":"10.1136\/bcr-2020-234591","article-title":"Adrenocortical neoplasm of uncertain malignant potential with a myelolipomatous component","volume":"13","author":"Balasubramanian","year":"2020","journal-title":"BMJ Case Rep."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1038\/modpathol.2013.230","article-title":"Comparative diagnostic and prognostic performances of the hematoxylin-eosin and phospho-histone H3 mitotic count and Ki-67 index in adrenocortical carcinoma","volume":"27","author":"Duregon","year":"2014","journal-title":"Mod. 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