{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T21:45:40Z","timestamp":1781732740594,"version":"3.54.5"},"reference-count":11,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2022,7,6]],"date-time":"2022-07-06T00:00:00Z","timestamp":1657065600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Research Foundation of Korea","award":["NRF-2022R1A2C2007739"],"award-info":[{"award-number":["NRF-2022R1A2C2007739"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Darier disease is an autosomal dominant disorder with dark crusty patches and is classified as hereditary acantholytic dermatosis. Keratotic papules and crust are often present on the scalp, forehead, chest, back, upper arms, elbows, groin, and behind the ears, predominantly in seborrheic areas. A 48-year-old male patient presented skin lesions with pruritus on the trunk and both upper and lower extremities. He first noticed the lesion 15 years before. On physical examination, there were multiple erythematous papules with crust on the trunk and red-brown colored keratotic plaque on both extremities. The suspected histopathological diagnosis was psoriasis vulgaris. The patient\u2019s skin lesions and pruritus were significantly improved after the psoriasis treatment. While continuing psoriasis treatment, the patient showed sudden worsening of the skin lesions on the scalp, abdomen, and fingernails (V-shaped nicks) with pruritus. Punch biopsy was performed on the abdominal lesion again and the final diagnosis was Darier disease. The patient was then treated using alitretinoin while maintaining the use of guselkumab for psoriasis. There are only a few cases that we found in which patients with Darier disease also had psoriasis. We report this rare case of Darier disease with psoriasis and propose that an additional biopsy might be necessary for accurate diagnosis and proper treatment.<\/jats:p>","DOI":"10.3390\/medicina58070902","type":"journal-article","created":{"date-parts":[[2022,7,6]],"date-time":"2022-07-06T09:41:10Z","timestamp":1657100470000},"page":"902","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Darier Disease with Psoriasis"],"prefix":"10.3390","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6532-2244","authenticated-orcid":false,"given":"Seok-Young","family":"Kang","sequence":"first","affiliation":[{"name":"Department of Dermatology, Kangnam Sacred Heart Hospital, Hallym University, Seoul 24252, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"So-Yeon","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Kangnam Sacred Heart Hospital, Hallym University, Seoul 24252, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Seo","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Kangnam Sacred Heart Hospital, Hallym University, Seoul 24252, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1523-6951","authenticated-orcid":false,"given":"Jin-Cheol","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Kangnam Sacred Heart Hospital, Hallym University, Seoul 24252, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2795-0140","authenticated-orcid":false,"given":"Bo-Young","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Kangnam Sacred Heart Hospital, Hallym University, Seoul 24252, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4512-8668","authenticated-orcid":false,"given":"Chun-Wook","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Kangnam Sacred Heart Hospital, Hallym University, Seoul 24252, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5846-0008","authenticated-orcid":false,"given":"Hye-One","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Kangnam Sacred Heart Hospital, Hallym University, Seoul 24252, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,7,6]]},"reference":[{"key":"ref_1","first-page":"97","article-title":"Darier\u2019s Disease; Epidemiology, Pathophysiology, and Management","volume":"4","author":"Susan","year":"2003","journal-title":"Am. 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Dermatol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1016\/j.bbamcr.2010.12.006","article-title":"Darier disease: A disease model of impaired calcium homeostasis in the skin","volume":"1813","author":"Savignac","year":"2011","journal-title":"Biochim. Biophys. Acta BBA-Mol. Cell Res."}],"container-title":["Medicina"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1648-9144\/58\/7\/902\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T23:43:28Z","timestamp":1760139808000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1648-9144\/58\/7\/902"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,6]]},"references-count":11,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2022,7]]}},"alternative-id":["medicina58070902"],"URL":"https:\/\/doi.org\/10.3390\/medicina58070902","relation":{},"ISSN":["1648-9144"],"issn-type":[{"value":"1648-9144","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,6]]}}}