{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T20:29:33Z","timestamp":1789417773381,"version":"build-2803163510"},"reference-count":122,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2022,7,11]],"date-time":"2022-07-11T00:00:00Z","timestamp":1657497600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Is a cyclic neuropeptide produced primarily in the hypothalamus and plays an important neuromodulatory role for other neurotransmitter systems, with an impact on behavior, response to danger, stress, and complex social interactions, such as pair bonding and child care. This narrative expert review examines the literature on oxytocin as a brain hormone. We focused on oxytocin structure, distribution, genetics, and the oxytocin receptor system, as well as the relationship of oxytocin with other neurotransmitters and the resulting impacts on the main psychiatric disorders. Oxytocin levels have been correlated over time with mental illness, with numerous studies focusing on oxytocin and the pathophysiology of the main psychiatric disorders, such as autism, schizophrenia, personality disorders, mood, and eating disorders. We highlight the role oxytocin plays in improving symptoms such as anxiety, depression, and social behavior, as the literature suggests. Risk factors and causes for psychiatric disorders range from genetic to environmental and social factors. Oxytocin could impact the latter, being linked with other neurotransmitter systems that are responsible for integrating different situations during the development phases of individuals. Also, these systems have an important role in how the body responds to stressors or bonding with others, helping with the creation of social support groups that could speed up recovery in many situations. Oxytocin has the potential to become a key therapeutic agent for future treatment and prevention strategies concerning the main psychiatric disorders.<\/jats:p>","DOI":"10.3390\/medicina58070923","type":"journal-article","created":{"date-parts":[[2022,7,11]],"date-time":"2022-07-11T21:57:53Z","timestamp":1657576673000},"page":"923","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Oxytocin: Narrative Expert Review of Current Perspectives on the Relationship with Other Neurotransmitters and the Impact on the Main Psychiatric Disorders"],"prefix":"10.3390","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8818-7022","authenticated-orcid":false,"given":"Tudor","family":"Florea","sequence":"first","affiliation":[{"name":"Department of Medicine III, Faculty of Medicine, Grigore T. Popa University of Medicine and Pharmacy of Iasi, 16 Universit\u0103\u021bii Street, 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matei","family":"Palimariciuc","sequence":"additional","affiliation":[{"name":"Department of Medicine III, Faculty of Medicine, Grigore T. Popa University of Medicine and Pharmacy of Iasi, 16 Universit\u0103\u021bii Street, 700115 Iasi, Romania"},{"name":"Institute of Psychiatry \u201cSocola\u201d, 36 Bucium Street, 700282 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Caterina","family":"Cristofor","sequence":"additional","affiliation":[{"name":"Department of Medicine III, Faculty of Medicine, Grigore T. Popa University of Medicine and Pharmacy of Iasi, 16 Universit\u0103\u021bii Street, 700115 Iasi, Romania"},{"name":"Institute of Psychiatry \u201cSocola\u201d, 36 Bucium Street, 700282 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina","family":"Dobrin","sequence":"additional","affiliation":[{"name":"Department of Medicine III, Faculty of Medicine, Grigore T. Popa University of Medicine and Pharmacy of Iasi, 16 Universit\u0103\u021bii Street, 700115 Iasi, Romania"},{"name":"Institute of Psychiatry \u201cSocola\u201d, 36 Bucium Street, 700282 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roxana","family":"Chiri\u021b\u0103","sequence":"additional","affiliation":[{"name":"Department of Medicine III, Faculty of Medicine, Grigore T. Popa University of Medicine and Pharmacy of Iasi, 16 Universit\u0103\u021bii Street, 700115 Iasi, Romania"},{"name":"Institute of Psychiatry \u201cSocola\u201d, 36 Bucium Street, 700282 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena","family":"B\u00eersan","sequence":"additional","affiliation":[{"name":"Department of Drug Industry and Pharmaceutical Biotechnology, Faculty of Pharmacy, Grigore T. Popa University of Medicine and Pharmacy of Ia\u015fi, 16 Universit\u0103\u0163ii Street, 700115 Ia\u015fi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3023-0205","authenticated-orcid":false,"given":"Romeo Petru","family":"Dobrin","sequence":"additional","affiliation":[{"name":"Department of Medicine III, Faculty of Medicine, Grigore T. Popa University of Medicine and Pharmacy of Iasi, 16 Universit\u0103\u021bii Street, 700115 Iasi, Romania"},{"name":"Institute of Psychiatry \u201cSocola\u201d, 36 Bucium Street, 700282 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela","family":"P\u0103durariu","sequence":"additional","affiliation":[{"name":"Institute of Psychiatry \u201cSocola\u201d, 36 Bucium Street, 700282 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,7,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1126\/science.6153132","article-title":"Synthesis, Transport, and Release of Posterior Pituitary Hormones","volume":"207","author":"Brownstein","year":"1980","journal-title":"Science"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1042\/BST0351252","article-title":"Stimuli and consequences of dendritic release of oxytocin within the brain","volume":"35","author":"Neumann","year":"2007","journal-title":"Biochem. 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