{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:55:10Z","timestamp":1787028910919,"version":"build-2736575974"},"reference-count":33,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2022,7,21]],"date-time":"2022-07-21T00:00:00Z","timestamp":1658361600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Backgroundand objectives: Although several vaccines have been produced and administered around the world, new SARS-CoV-2 worsened the COVID-19 infection risk and impacted the initial vaccine dosage effectiveness. Based on studies indicating that the third and fourth COVID-19 vaccine doses significantly reduced COVID-19 transmission, Saudi Arabia has been administering COVID-19 booster vaccine doses to its citizens. The purpose of this study was to evaluate the uptake of the COVID-19 vaccine booster in relation to the socio-demographic characteristics and other associated factors among the Saudi population. Materials and Methods: This study was an online analytical cross-sectional study using a self-administered questionnaire. Pearson Chi-square test and multiple logistic regression analyses were used to determine factors associated with the uptake of COVID-19 booster dose vaccines. Results: A total of 2332 responded to our study. Overall, 527 (22.6%) participants had received a booster dose. An age of 55 and above (aOR: 5.415; 95% CI: 2.719\u201310.783), Eastern region (aOR: 2.513; 95% CI: 1.566\u20134.033), history of influenza vaccination at annual intervals (aOR: 2.387; 95% CI: 1.730\u20133.293), the first dose of Moderna vaccine (aOR: 1.324; 95% CI: 1.160\u20131.510), and cancer (aOR: 2.161; 95% CI: 1.218\u20133.879) were independent factors most associated with a higher uptake of the COVID-19 vaccine booster dose. In contrast, the second dose of Moderna vaccine (aOR: 0.794; 95% CI: 0.683\u20130.922), AstraZeneca vaccine (aOR: 0.691; 95% CI: 0.509\u20130.939), strong symptoms from side effects after the second dose of the COVID-19 vaccine (aOR: 0.615; 95% CI: 0.404\u20130.935) were independent factors most associated with a lower uptake of the COVID-19 vaccine booster dose. Conclusions: Our findings indicate low COVID-19 vaccine booster uptake. This necessitates the need for strategies to address discouraging factors of the COVID-19 vaccine booster dose uptake and engage the Saudi population to raise awareness about the importance of the booster dose.<\/jats:p>","DOI":"10.3390\/medicina58070972","type":"journal-article","created":{"date-parts":[[2022,7,21]],"date-time":"2022-07-21T22:38:50Z","timestamp":1658443130000},"page":"972","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Uptake of COVID-19 Booster Dose among Saudi Arabian Population"],"prefix":"10.3390","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2163-004X","authenticated-orcid":false,"given":"Najim Z.","family":"Alshahrani","sequence":"first","affiliation":[{"name":"Department of Family and Community Medicine, Faculty of Medicine, University of Jeddah, Jeddah 21589, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdullah A.","family":"Alsabaani","sequence":"additional","affiliation":[{"name":"Department of Family and Community Medicine, College of Medicine, King Khalid University, Abha 62529, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iman","family":"Ridda","sequence":"additional","affiliation":[{"name":"Department of Public Health, National University of Natural Medicine, Portland, OR 97201, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2286-5139","authenticated-orcid":false,"given":"Harunor","family":"Rashid","sequence":"additional","affiliation":[{"name":"National Centre for Immunisation Research and Surveillance (NCIRS), Westmead, NSW 2145, Australia"},{"name":"Discipline of Child and Adolescent Health, The Children\u2019s Hospital at Westmead Clinical School, Westmead, NSW 2145, Australia"},{"name":"Marie Bashir Institute for Infectious Diseases and Biosecurity, School of Biological Sciences and Sydney Medical School, The University of Sydney, Westmead, NSW 2145, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faris","family":"Alzahrani","sequence":"additional","affiliation":[{"name":"Department of Public Health, General Directorate of Health Affairs in Aseer Region, Ministry of Health, Abha 62523, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Talal Hamed","family":"Almutairi","sequence":"additional","affiliation":[{"name":"College of Medicine, King Saud Bin Abdulaziz University for Health Sciences (KSAU-HS), Riyadh 14611, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bader Ahmed S.","family":"Alzahrani","sequence":"additional","affiliation":[{"name":"General Directorate of Health Affairs, Ministry of Health, Jeddah 23222, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdulelah Saleh Saeed","family":"Albeshri","sequence":"additional","affiliation":[{"name":"College of Medicine, King Khalid University, Abha 62529, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,7,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"4115","DOI":"10.1002\/jmv.27825","article-title":"Acceptance of COVID-19 Booster Vaccination Based on the Protection Motivation Theory: A Cross-sectional Study in China","volume":"94","author":"Wu","year":"2022","journal-title":"J. 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