{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T01:05:29Z","timestamp":1788829529122,"version":"build-2803163510"},"reference-count":20,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2022,7,28]],"date-time":"2022-07-28T00:00:00Z","timestamp":1658966400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005289","name":"the Provincial Secretariat for Science and Technological Development","doi-asserted-by":"publisher","award":["142-451-2619\/2021"],"award-info":[{"award-number":["142-451-2619\/2021"]}],"id":[{"id":"10.13039\/501100005289","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: The COVID-19 pandemic has led to significant changes globally, which has also affected patients with type 1 diabetes mellitus (T1DM). This study aimed to determine the incidence of T1DM and the characteristics of diabetic ketoacidosis (DKA) during the pandemic comparing it to pre-pandemic period. Materials and Methods: Data from patients &lt;19 years with newly diagnosed T1DM between 1st January 2017 and 31st December 2021 from four regional centers in Vojvodina were retrospectively collected and analyzed. Results: In 2021, the highest incidence of T1DM in the last five years was recorded, 17.3\/100,000. During the pandemic period (2020\u20132021), there were 99 new-onset T1DM, of which 42.4% presented in DKA, which is significantly higher than in the pre-pandemic period (34.1%). During the pandemic, symptom duration of T1DM lasted significantly longer than before the COVID-19 period. At the age of 10\u201314 years, the highest incidence of T1DM and COVID-19, the highest frequency rate of DKA, and severe DKA were observed. Conclusions: The pandemic is associated with a high incidence rate of T1DM, longer duration of symptoms of T1DM, a high frequency of DKA, and a severe DKA at diagnosis. Patients aged 10\u201314 years are a risk group for the occurrence of T1DM with severe clinical presentation. Additional studies are needed with a longer study period and in a wider geographical area, with data on exposure to COVID-19 infection, the permanence of new-onset T1DM, and the psychosocial impact of the pandemic.<\/jats:p>","DOI":"10.3390\/medicina58081013","type":"journal-article","created":{"date-parts":[[2022,7,28]],"date-time":"2022-07-28T22:43:26Z","timestamp":1659048206000},"page":"1013","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Incidence of Type 1 Diabetes Mellitus and Characteristics of Diabetic Ketoacidosis in Children and Adolescents during the First Two Years of the COVID-19 Pandemic in Vojvodina"],"prefix":"10.3390","volume":"58","author":[{"given":"Ivana","family":"Vorgu\u010din","sequence":"first","affiliation":[{"name":"Institute for Child and Youth Health Care of Vojvodina, 21000 Novi Sad, Serbia"},{"name":"Faculty of Medicine, University of Novi Sad, 21000 Novi Sad, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7393-1998","authenticated-orcid":false,"given":"Marijana","family":"Savin","sequence":"additional","affiliation":[{"name":"Institute for Child and Youth Health Care of Vojvodina, 21000 Novi Sad, Serbia"},{"name":"Faculty of Medicine, University of Novi Sad, 21000 Novi Sad, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0110ur\u0111ina","family":"Stankovi\u0107","sequence":"additional","affiliation":[{"name":"Institute for Child and Youth Health Care of Vojvodina, 21000 Novi Sad, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dejan","family":"Miljkovi\u0107","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Novi Sad, 21000 Novi Sad, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatjana","family":"Ili\u0107","sequence":"additional","affiliation":[{"name":"General Hospital Subotica, 24000 Subotica, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danijela","family":"Simi\u0107","sequence":"additional","affiliation":[{"name":"General Hospital Sombor, 25000 Sombor, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirjana","family":"Vrebalov","sequence":"additional","affiliation":[{"name":"General Hospital Zrenjanin, 23000 Zrenjanin, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Borko","family":"Milanovi\u0107","sequence":"additional","affiliation":[{"name":"Institute for Child and Youth Health Care of Vojvodina, 21000 Novi Sad, Serbia"},{"name":"Faculty of Medicine, University of Novi Sad, 21000 Novi Sad, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6881-7856","authenticated-orcid":false,"given":"Nenad","family":"Bari\u0161i\u0107","sequence":"additional","affiliation":[{"name":"Institute for Child and Youth Health Care of Vojvodina, 21000 Novi Sad, Serbia"},{"name":"Faculty of Medicine, University of Novi Sad, 21000 Novi Sad, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vesna","family":"Stojanovi\u0107","sequence":"additional","affiliation":[{"name":"Institute for Child and Youth Health Care of Vojvodina, 21000 Novi Sad, Serbia"},{"name":"Faculty of Medicine, University of Novi Sad, 21000 Novi Sad, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gordana","family":"Vijatov-\u0110uri\u0107","sequence":"additional","affiliation":[{"name":"Institute for Child and Youth Health Care of Vojvodina, 21000 Novi Sad, Serbia"},{"name":"Faculty of Medicine, University of Novi Sad, 21000 Novi Sad, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarina","family":"Kopriv\u0161ek","sequence":"additional","affiliation":[{"name":"Institute for Child and Youth Health Care of Vojvodina, 21000 Novi Sad, Serbia"},{"name":"Faculty of Medicine, University of Novi Sad, 21000 Novi Sad, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gordana","family":"Vilotijevi\u0107-Dautovi\u0107","sequence":"additional","affiliation":[{"name":"Institute for Child and Youth Health Care of Vojvodina, 21000 Novi Sad, Serbia"},{"name":"Faculty of Medicine, University of Novi Sad, 21000 Novi Sad, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jelena","family":"Anti\u0107","sequence":"additional","affiliation":[{"name":"Institute for Child and Youth Health Care of Vojvodina, 21000 Novi Sad, Serbia"},{"name":"Faculty of Medicine, University of Novi Sad, 21000 Novi Sad, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,7,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2631","DOI":"10.2337\/dci20-0044","article-title":"COVID-19 and Children with Diabetes\u2014Updates, Unknowns, and Next Steps: First, Do No 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