{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T05:24:09Z","timestamp":1762061049754,"version":"build-2065373602"},"reference-count":25,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2022,8,10]],"date-time":"2022-08-10T00:00:00Z","timestamp":1660089600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"AC Camargo Cancer Center"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: Patients with recurrent squamous cell carcinoma of the head and neck (rHNC) face an aggressive disease. Surgical resection is the gold standard treatment. Immediate adjuvant post-operative stereotactic ablative radiotherapy (PO-SABR) for rHNC is debatable. Materials and Methods: We retrospectively identified patients who were treated with PO-SABR at the AC Camargo Cancer Center, Brazil. Results: Eleven patients were treated between 2018 and 2021. The median time between salvage surgery and PO-SABR was 31 days (range, 25\u201342) and the median PO-SABR total dose was 40 Gy (range, 30\u201348 Gy). The 2-and 4-year actuarial DFS were 62.3% and 41.6%, while the 2-and 4-year OS probabilities were 80.0% and 53.3%, respectively. Eight (72.7%) patients were alive and six (54.5%) were without disease at the last follow-up. Two (18.1%) patients had local failure in the PO-SABR field. Three (27.3%) patients had distant metastasis, diagnosed in a median time of 9 months (range, 4\u201313) after completion of PO-SABR. On univariate analysis, predictive factors related to worse OS were: interval between previous radiotherapy and PO-SABR \u2264 24 months (p = 0.033) and location of the salvage target in the oral cavity (p = 0.013). The total dose of PO-SABR given in more than three fractions was marginally statistically significant, favoring the OS (p = 0.051). Conclusions: Our results encourage the use of a more aggressive approach in selected patients with rHNC by combining salvage surgery with immediate PO-SABRT, but this association needs to be further explored.<\/jats:p>","DOI":"10.3390\/medicina58081074","type":"journal-article","created":{"date-parts":[[2022,8,10]],"date-time":"2022-08-10T04:20:32Z","timestamp":1660105232000},"page":"1074","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Salvage Post-Operative Stereotatic Ablative Radiotherapy for Re-Current Squamous Cell Carcinoma of Head and Neck"],"prefix":"10.3390","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2083-5545","authenticated-orcid":false,"given":"Antonio","family":"Pellizzon","sequence":"first","affiliation":[{"name":"AC Camargo Cancer Center, Sao Paulo 01509-010, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3293-5420","authenticated-orcid":false,"given":"Maria","family":"Silva","sequence":"additional","affiliation":[{"name":"AC Camargo Cancer Center, Sao Paulo 01509-010, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo","family":"Fogaroli","sequence":"additional","affiliation":[{"name":"AC Camargo Cancer Center, Sao Paulo 01509-010, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elson","family":"Neto","sequence":"additional","affiliation":[{"name":"AC Camargo Cancer Center, Sao Paulo 01509-010, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7897-7733","authenticated-orcid":false,"given":"Michael","family":"Chen","sequence":"additional","affiliation":[{"name":"AC Camargo Cancer Center, Sao Paulo 01509-010, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guilherme","family":"Godim","sequence":"additional","affiliation":[{"name":"AC Camargo Cancer Center, Sao Paulo 01509-010, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Douglas","family":"Castro","sequence":"additional","affiliation":[{"name":"AC Camargo Cancer Center, Sao Paulo 01509-010, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henderson","family":"Ramos","sequence":"additional","affiliation":[{"name":"AC Camargo Cancer Center, Sao Paulo 01509-010, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolina","family":"Abrahao","sequence":"additional","affiliation":[{"name":"AC Camargo Cancer Center, Sao Paulo 01509-010, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,8,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"394","DOI":"10.3322\/caac.21492","article-title":"Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"68","author":"Bray","year":"2018","journal-title":"CA Cancer J. 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