{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T18:23:25Z","timestamp":1761157405017,"version":"build-2065373602"},"reference-count":19,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2022,8,12]],"date-time":"2022-08-12T00:00:00Z","timestamp":1660262400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>With an intricate symptom pattern involving a dysregulated host response to infection, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can cause severe inflammation and cytokine storms, acute respiratory distress syndrome, coagulopathy, multi-organ failure, and finally death. The uniqueness of this case report lies in the nature of the therapeutic intervention performed. While numerous studies are available on both the use of therapeutic plasma exchange in coronavirus disease 2019 (COVID-19) patients and convalescent plasma transfusion as separate treatment methods, there is very little information regarding the combination of these procedures. We present the case of a 52-year-old male, unvaccinated for COVID-19, who tested positive on reverse transcriptase polymerase chain reaction for SARS-CoV-2 for the first time and presented in the emergency room with fever, chills, severe cough, tachypnea, tachycardia, and dyspnea that started two days before presentation. Upon rapid assessment, the patient showed signs of acute respiratory failure, so it was decided to transfer the patient to the intensive care unit, COVID-19 ward, after preliminary radiological examination. For the next 24 days, the patient was stationed in the intensive care unit, where he was closely monitored and treated. Invasive mechanical ventilation was required following the initial worsening of his respiratory status. We performed therapeutic plasma exchange on the first day of his stay in the intensive care unit, and immediately after the procedure, the patient was transfused with 500 mL of convalescent plasma from healthy donors. The patient\u2019s condition improved over the next few days, which led to the cessation of mechanical ventilation and, after treating the superinfection, the patient was discharged home, making a full recovery. The early initiation of therapeutic plasma exchange followed by transfusion of convalescent plasma in severe and critical forms of COVID-19 may reduce the risk of the progression of the disease and ultimately reduce the risk of negative outcomes in a selected group of patients.<\/jats:p>","DOI":"10.3390\/medicina58081088","type":"journal-article","created":{"date-parts":[[2022,8,15]],"date-time":"2022-08-15T03:33:20Z","timestamp":1660534400000},"page":"1088","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The Successful Recovery of a Critically Ill COVID-19 Patient, Following the Combination of Therapeutic Plasma Exchange and Convalescent Plasma Transfusion: A Case Report"],"prefix":"10.3390","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9829-9412","authenticated-orcid":false,"given":"Alexandru Noris","family":"Novacescu","sequence":"first","affiliation":[{"name":"Doctoral School, \u2018Victor Babes\u2019 University of Medicine and Pharmacy, 300041 Timisoara, Romania"},{"name":"Anesthesia and Intensive Care Unit, \u2018Dr. Victor Babes\u2019 Infectious Diseases and Pneumology Clinical Hospital, 300310 Timisoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georgiana","family":"Duma","sequence":"additional","affiliation":[{"name":"Anesthesia and Intensive Care Unit, \u2018Dr. Teodor Andrei\u2019 Municipal Hospital, 305500 Lugoj, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorel","family":"Sandesc","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Intensive Care, \u2018Victor Babes\u2019 University of Medicine and Pharmacy, 300041 Timisoara, Romania"},{"name":"Anesthesia and Intensive Care Unit, \u2018Pius Br\u00eenzeu\u2019 Emergency Clinical County Hospital, 300723 Timisoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4086-0991","authenticated-orcid":false,"given":"Teodora","family":"Sorescu","sequence":"additional","affiliation":[{"name":"Department of Diabetes, Nutrition and Metabolic Diseases, \u2018Victor Babes\u2019 University of Medicine and Pharmacy, 300041 Timisoara, Romania"},{"name":"Department of Diabetes, Nutrition and Metabolic Diseases, \u2018Pius Br\u00eenzeu\u2019 Emergency Clinical County Hospital, 300723 Timisoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9245-5883","authenticated-orcid":false,"given":"Monica","family":"Licker","sequence":"additional","affiliation":[{"name":"Department of Microbiology, \u2018Victor Babes\u2019 University of Medicine and Pharmacy, 300041 Timisoara, Romania"},{"name":"Multidisciplinary Research Center on Antimicrobial Resistance, \u2018Victor Babes\u2019 University of Medicine and Pharmacy, 300041 Timisoara, Romania"},{"name":"Bacteriology Laboratory, \u2018Pius Br\u00eenzeu\u2019 Emergency Clinical County Hospital, 300723 Timisoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,8,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1001\/jama.2020.12839","article-title":"Pathophysiology, transmission, diagnosis, and treatment of Coronavirus Disease 2019 (COVID-19): A review","volume":"324","author":"Wiersinga","year":"2020","journal-title":"JAMA"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"31","DOI":"10.2147\/BTT.S272063","article-title":"Convalescent plasma for the treatment of severe COVID-19","volume":"15","author":"Franchini","year":"2021","journal-title":"Biol. Targets Ther."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1001\/jama.2020.10044","article-title":"Effect of convalescent plasma therapy on time to clinical improvement in patients with severe and life-threatening COVID-19: A randomized clinical trial","volume":"324","author":"Li","year":"2020","journal-title":"JAMA"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1038\/s41591-020-1088-9","article-title":"Convalescent plasma treatment of severe COVID-19: A matched control study","volume":"26","author":"Liu","year":"2020","journal-title":"Nat. Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1182\/blood.2020007079","article-title":"Improved clinical symptoms and mortality among patients with severe or critical COVID-19 after convalescent plasma transfusion","volume":"136","author":"Xia","year":"2020","journal-title":"Blood"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1186\/s13054-020-2836-4","article-title":"A novel treatment approach to the novel coronavirus: An argument for the use of therapeutic plasma exchange for fulminant COVID-19","volume":"24","author":"Keith","year":"2020","journal-title":"Crit. Care"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.ijid.2020.06.064","article-title":"Therapeutic plasma exchange in adults with severe COVID-19 infection","volume":"99","author":"Khamis","year":"2020","journal-title":"Int. J. Infect. Dis."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1186\/s13054-020-03215-8","article-title":"Therapeutic plasma exchange in patients with COVID-19 pneumonia in intensive care unit: A retrospective study","volume":"24","author":"Gucyetmez","year":"2020","journal-title":"Crit. Care"},{"key":"ref_9","first-page":"041","article-title":"Therapeutic plasma exchange and COVID-19: A rapid review","volume":"6","author":"Sarfraz","year":"2020","journal-title":"Clin. Immunol. Immunother."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"102993","DOI":"10.1016\/j.transci.2020.102993","article-title":"Potential of therapeutic plasmapheresis in treatment of COVID-19 patients: Immunopathogenesis and coagulopathy","volume":"59","author":"Balagholi","year":"2020","journal-title":"Transfus. Apher. Sci."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Kamran, S.M., Mirza, Z.E., Naseem, A., Liaqat, J., Fazal, I., Alamgir, W., Saeed, F., Saleem, S., Nisar, S., and Yousaf, M.A. (2021). Therapeutic plasma exchange for coronavirus disease-2019 triggered cytokine release syndrome; a retrospective propensity matched control study. PLoS ONE, 16.","DOI":"10.1371\/journal.pone.0244853"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.ijid.2020.10.085","article-title":"Therapeutic plasma exchange followed by convalescent plasma transfusion in critical COVID-19\u2014An exploratory study","volume":"102","author":"Jaiswal","year":"2021","journal-title":"Int. J. Infect. Dis."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"The ARDS Definition Task Force (2012). Acute respiratory distress syndrome: The Berlin definition. JAMA, 307, 2526\u20132533.","DOI":"10.1001\/jama.2012.5669"},{"key":"ref_14","first-page":"E001","article-title":"Interpretation of \u201cGuidelines for the diagnosis and treatment of novel coronavirus (2019-nCoV) infection by the national health commission (Trial Version 5)\u201d","volume":"100","author":"Lin","year":"2020","journal-title":"Zhonghua Yi Xue Za Zhi"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.rx.2020.11.001","article-title":"Radiologic diagnosis of patients with COVID-19","volume":"63","year":"2021","journal-title":"Radiolog\u00eda"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1186\/s13054-020-03262-1","article-title":"Plasma exchange in critically ill COVID-19 patients improved inflammation, microcirculatory clot formation, and hypotension, thereby improving clinical outcomes: Fact or fiction?","volume":"24","author":"Honore","year":"2020","journal-title":"Crit. Care"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"76","DOI":"10.3892\/etm.2021.10999","article-title":"Therapeutic plasma exchange followed by convalescent plasma transfusion in severe and critically ill COVID-19 patients: A single centre non-randomized controlled trial","volume":"23","author":"Novacescu","year":"2022","journal-title":"Exp. Ther. Med."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"110139","DOI":"10.1016\/j.mehy.2020.110139","article-title":"Ventilator-associated pneumonia (VAP) caused by carbapenem-resistant Acinetobacter baumannii in patients with COVID-19: Two problems, one solution?","volume":"144","author":"Lima","year":"2020","journal-title":"Med. Hypotheses"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"5493","DOI":"10.1038\/s41467-020-19057-5","article-title":"SARS-CoV-2 viral load is associated with increased disease severity and mortality","volume":"11","author":"Fajnzylber","year":"2020","journal-title":"Nat. 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