{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T06:24:19Z","timestamp":1762064659074,"version":"build-2065373602"},"reference-count":46,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2022,8,23]],"date-time":"2022-08-23T00:00:00Z","timestamp":1661212800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Lymphoepithelioma-like breast carcinoma (LELC) is a rare type of malignant breast tumor that is not included in the current edition of the World Health Organization (WHO) classification of breast tumors. Currently, there are no clearly defined therapeutic strategies, and the general information on breast LELC is based on sporadic clinical cases described in the medical literature. We present a clinical case that describes a 49-year-old woman with a tumor formation in the right breast, histologically verified as LELC, together with a non-palpable, synchronous high-grade invasive ductal carcinoma and ductal carcinoma in situ Grade 2 (DCIS G2) in a different quadrant of the same breast. To our knowledge, this is the first case described in the literature that combines a LELC with a synchronous carcinoma in the same breast.<\/jats:p>","DOI":"10.3390\/medicina58091146","type":"journal-article","created":{"date-parts":[[2022,8,24]],"date-time":"2022-08-24T00:22:48Z","timestamp":1661300568000},"page":"1146","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Lymphoepithelioma-like Carcinoma of the Breast Synchronous with a High-Grade Invasive Ductal Carcinoma and Ductal Carcinoma in Situ in a Different Quadrant of the Same Breast: A Case Report"],"prefix":"10.3390","volume":"58","author":[{"given":"Vasil","family":"Nanev","sequence":"first","affiliation":[{"name":"Department of Surgical Oncology, Dr. Georgi Stranski University Hospital, Medical University\u2014Pleven, 5800 Pleven, Bulgaria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Naneva","sequence":"additional","affiliation":[{"name":"Hematology Clinic, Dr. Georgi Stranski University Hospital, Medical University\u2014Pleven, 5800 Pleven, Bulgaria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7719-382X","authenticated-orcid":false,"given":"Angel","family":"Yordanov","sequence":"additional","affiliation":[{"name":"Department of Gynaecologic Oncology, Medical University\u2014Pleven, 5800 Pleven, Bulgaria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4104-948X","authenticated-orcid":false,"given":"Strahil","family":"Strashilov","sequence":"additional","affiliation":[{"name":"Department of Plastic, Reconstructive and Aesthetic Surgery, Dr. Georgi Stranski University Hospital, Medical University\u2014Pleven, 5800 Pleven, Bulgaria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7560-8032","authenticated-orcid":false,"given":"Assia","family":"Konsoulova","sequence":"additional","affiliation":[{"name":"USHATO\u2014Sofia National University Cancer Hospital, 1000 Sofia, Bulgaria"},{"name":"Women for Oncology, 1000 Sofia, Bulgaria"},{"name":"Department of Preclinical and Clinical Disciplines, Faculty of Social Health and Healthcare, University Prof. A. Zlatarov, 8000 Burgas, Bulgaria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6180-3742","authenticated-orcid":false,"given":"Mariela","family":"Vasileva-Slaveva","sequence":"additional","affiliation":[{"name":"Department of Breast surgery, Shterev Hospital, 1000 Sofia, Bulgaria"},{"name":"Research Institute, Medical University\u2014Pleven, 5800 Pleven, Bulgaria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatyana","family":"Betova","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology, Dr. Georgi Stranski University Hospital, Medical University\u2014Pleven, 5800 Pleven, Bulgaria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivan","family":"Ivanov","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology, Dr. Georgi Stranski University Hospital, Medical University\u2014Pleven, 5800 Pleven, Bulgaria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,8,23]]},"reference":[{"key":"ref_1","unstructured":"WHO (2019). 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