{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T22:50:40Z","timestamp":1780527040360,"version":"3.54.1"},"reference-count":32,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2022,9,5]],"date-time":"2022-09-05T00:00:00Z","timestamp":1662336000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Castleman disease constitutes a rare class of lymphoproliferative disorders, with an estimated incidence of 21 to 25 per million patient years. The idiopathic subtype exhibits a significantly diverse clinical presentation, which can imitate many autoimmune, malignant, and infectious diseases. Cutaneous manifestations are uncommon and require in-depth investigation, especially when concurrent lymphadenopathy is present. A 79-year-old female, with a chronic, complicated erysipelas-like lesion, presented with bilaterally enlarged inguinal lymph nodes; after surgical excision, their histopathological examination revealed Castleman disease. Even though it is a benign condition, patients are often predisposed to developing certain types of malignancies, which can deteriorate their prognosis. An accurate and early diagnosis, along with effective treatment and prevention of recurrence, is of utmost importance in order to increase the patients\u2019 overall survival and quality of life.<\/jats:p>","DOI":"10.3390\/medicina58091222","type":"journal-article","created":{"date-parts":[[2022,9,6]],"date-time":"2022-09-06T22:33:01Z","timestamp":1662503581000},"page":"1222","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Idiopathic Multicentric Castleman Disease with Cutaneous Manifestation: Case Report"],"prefix":"10.3390","volume":"58","author":[{"given":"Christoforos S.","family":"Kosmidis","sequence":"first","affiliation":[{"name":"European Interbalkan Medical Center, 10 Asklipiou Street, 55535 Pylaia, Greece"},{"name":"3rd Surgical Department, University General Hospital of Thessaloniki \u201cAHEPA\u201d, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, 1st St. Kiriakidi Street, 54621 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6674-7500","authenticated-orcid":false,"given":"Chrysi Maria","family":"Mystakidou","sequence":"additional","affiliation":[{"name":"Medical School, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0669-6980","authenticated-orcid":false,"given":"Georgios","family":"Koimtzis","sequence":"additional","affiliation":[{"name":"Cardiff Transplant Unit, University Hospital of Wales, Cardiff and Vale University Health Board, Cardiff CF14 4XW, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evanthia","family":"Papadopoulou","sequence":"additional","affiliation":[{"name":"Shakolas Educational Centre for Clinical Medicine, University of Cyprus, Old Road Nicosia-Lemesos 215\/6, 1678 Nicosia, Cyprus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasiliki","family":"Theodorou","sequence":"additional","affiliation":[{"name":"Medical School, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaos Iason","family":"Katsios","sequence":"additional","affiliation":[{"name":"Medical School, Faculty of Health Sciences, University of Ioannina, 45110 Ioannina, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleni","family":"Georgakoudi","sequence":"additional","affiliation":[{"name":"European Interbalkan Medical Center, 10 Asklipiou Street, 55535 Pylaia, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9869-7835","authenticated-orcid":false,"given":"Christina","family":"Sevva","sequence":"additional","affiliation":[{"name":"3rd Surgical Department, University General Hospital of Thessaloniki \u201cAHEPA\u201d, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, 1st St. Kiriakidi Street, 54621 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioannis","family":"Charalampous","sequence":"additional","affiliation":[{"name":"3rd Surgical Department, University General Hospital of Thessaloniki \u201cAHEPA\u201d, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, 1st St. Kiriakidi Street, 54621 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5849-5515","authenticated-orcid":false,"given":"Nikolaos","family":"Varsamis","sequence":"additional","affiliation":[{"name":"European Interbalkan Medical Center, 10 Asklipiou Street, 55535 Pylaia, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charilaos","family":"Koulouris","sequence":"additional","affiliation":[{"name":"European Interbalkan Medical Center, 10 Asklipiou Street, 55535 Pylaia, Greece"},{"name":"3rd Surgical Department, University General Hospital of Thessaloniki \u201cAHEPA\u201d, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, 1st St. Kiriakidi Street, 54621 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6380-8187","authenticated-orcid":false,"given":"Christina","family":"Michael","sequence":"additional","affiliation":[{"name":"Medical School, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos","family":"Papadopoulos","sequence":"additional","affiliation":[{"name":"3rd Surgical Department, University General Hospital of Thessaloniki \u201cAHEPA\u201d, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, 1st St. Kiriakidi Street, 54621 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