{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T22:10:38Z","timestamp":1792188638965,"version":"4.4.0"},"reference-count":15,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2022,9,12]],"date-time":"2022-09-12T00:00:00Z","timestamp":1662940800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>We describe the unusual case of a young woman with tubulointerstitial nephritis and uveitis (TINU) with bilateral diffuse uveitis and optic nerve inflammatory involvement since she was a child in the 1990s. Imaging diagnostic tools such as fluorescein angiography, indocyanine green angiography, optical coherence tomography (OCT), and OCT angiography revealed inactive juxtapapillary choroidal neovascularization (CNV) after 25 years of follow-up. After treatment, uveitis went into remission with BCVA 20\/20 in both eyes and CNV lesions became inactive. Although anterior uveitis is more frequently reported in TINU, posterior uveitis with inflammatory involvement of the optic nerve should be accurately investigated to rule out juxtapapillary CNV, both at the time of active uveitis and during follow-up, since TINU may be complicated by CNV even at the later stages of the inflammatory process.<\/jats:p>","DOI":"10.3390\/medicina58091260","type":"journal-article","created":{"date-parts":[[2022,9,13]],"date-time":"2022-09-13T01:44:03Z","timestamp":1663033443000},"page":"1260","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Juxtapapillary Choroidal Neovascularization in a Young Woman with Tubulointerstitial Nephritis and Uveitis (TINU) Syndrome with Onset in Pediatric Age"],"prefix":"10.3390","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4395-4774","authenticated-orcid":false,"given":"Maria","family":"Paroli","sequence":"first","affiliation":[{"name":"Eye Clinic, Department of Sense Organs, Sapienza University of Rome, Policlinico Umberto I Hospital, Viale del Policlinico 155, 00161 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8537-353X","authenticated-orcid":false,"given":"Daniele","family":"Cappiello","sequence":"additional","affiliation":[{"name":"Eye Clinic, Department of Sense Organs, Sapienza University of Rome, Policlinico Umberto I Hospital, Viale del Policlinico 155, 00161 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davide","family":"Staccini","sequence":"additional","affiliation":[{"name":"Eye Clinic, Department of Sense Organs, Sapienza University of Rome, Policlinico Umberto I Hospital, Viale del Policlinico 155, 00161 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4281-1103","authenticated-orcid":false,"given":"Anna","family":"Tamburrelli","sequence":"additional","affiliation":[{"name":"Eye Clinic, Department of Sense Organs, Sapienza University of Rome, Policlinico Umberto I Hospital, Viale del Policlinico 155, 00161 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7919-9128","authenticated-orcid":false,"given":"Marino","family":"Paroli","sequence":"additional","affiliation":[{"name":"Department of Clinical, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome, ICOT Hospital, 04100 Latina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1790-3532","authenticated-orcid":false,"given":"Ludovico","family":"Iannetti","sequence":"additional","affiliation":[{"name":"Eye Clinic, Department of Sense Organs, Sapienza University of Rome, Policlinico Umberto I Hospital, Viale del Policlinico 155, 00161 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,9,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1016\/0002-9394(88)90247-4","article-title":"Bilateral anterior uveitis and interstitial nephritis","volume":"105","author":"Rosenbaum","year":"1988","journal-title":"Am. 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