{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T04:44:04Z","timestamp":1760244244595,"version":"build-2065373602"},"reference-count":33,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2022,9,15]],"date-time":"2022-09-15T00:00:00Z","timestamp":1663200000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Sciences","award":["2012ZX10002-016","2012ZX10002-017","81400636","2019YFS0203","2020HXFH028"],"award-info":[{"award-number":["2012ZX10002-016","2012ZX10002-017","81400636","2019YFS0203","2020HXFH028"]}]},{"name":"Technology Major Project of China","award":["2012ZX10002-016","2012ZX10002-017","81400636","2019YFS0203","2020HXFH028"],"award-info":[{"award-number":["2012ZX10002-016","2012ZX10002-017","81400636","2019YFS0203","2020HXFH028"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2012ZX10002-016","2012ZX10002-017","81400636","2019YFS0203","2020HXFH028"],"award-info":[{"award-number":["2012ZX10002-016","2012ZX10002-017","81400636","2019YFS0203","2020HXFH028"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Sichuan Province Key Research and Development Project","award":["2012ZX10002-016","2012ZX10002-017","81400636","2019YFS0203","2020HXFH028"],"award-info":[{"award-number":["2012ZX10002-016","2012ZX10002-017","81400636","2019YFS0203","2020HXFH028"]}]},{"name":"Key Project of Clinical Research Incubation in West China Hospital of Sichuan University","award":["2012ZX10002-016","2012ZX10002-017","81400636","2019YFS0203","2020HXFH028"],"award-info":[{"award-number":["2012ZX10002-016","2012ZX10002-017","81400636","2019YFS0203","2020HXFH028"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objective: The study aims to investigate the correlation between Hepatitis B \u2018e\u2019 antigen (HBeAg) and HBV DNA levels, and to find a convenient tool to estimate the HBV DNA level for clinicians. Materials and Methods: We enrolled 1020 patients in this cross-sectional study and divided them into four groups: an HbeAg-positive and -negative group, and high and low HBV DNA levels groups. Results: Alanine aminotransferase (ALT), Albumin (ALB) and HBeAg are independent risk factors for CHB patients. When the level of HBeAg is higher than 16.15 S\/CO, it is four times more likely that the patients will have high levels of HBV DNA than those who do not. The ALT and TB are independent risk factors in HBeAg-negative patients with a high HBV DNA level. We have drawn three predictive models to estimate the HBV DNA levels for those with the chronic hepatitis B virus (CHB), and those that are HBeAg-positive and HBeAg-negative (Y1 = 0.004 \u00d7 ALT(IU\/L) + 1.412 \u00d7 HBeAg (S\/CO) \u2212 0.029 \u00d7 ALB (g\/L) + 0.779, the AUC is 0.672, and the cutoff value is \u22120.072, there the sensitivity is 0.615, the specificity is 0.648, PPV is 65.182% and NPV is 60.837%; Y2 = 0.007 \u00d7 HBeAg (S\/CO) \u2212 0.016 \u00d7 HGB (g\/L) + 3.070, the AUC is 0.724, and the cutoff value is 1.216, where the sensitivity is 0.626, the specificity is 0.897, PPV is 94.118% and NPV is 34.437%; Y3 = \u22120.005 \u00d7 ALT(IU\/L) + 0.006 \u00d7 TB (umol\/L) + 0.385, the AUC is 0.661, and the cutoff value is 0.263, where the sensitivity is 0.677, the specificity is 0.587, PPV is 66.820% and NPV is 40.774%, respectively). We propose that HBeAg is the most important risk factor for the patient with a high HBV DNA level, however, it is not as important in the HBeAg-positive group. Conclusions: HBeAg is an independent risk factor that reflects the level of HBV DNA with a strong correlation. Patient with HBeAg (\u2212) should combine TB and ALT to estimate the level of HBV DNA.<\/jats:p>","DOI":"10.3390\/medicina58091279","type":"journal-article","created":{"date-parts":[[2022,9,16]],"date-time":"2022-09-16T01:35:10Z","timestamp":1663292110000},"page":"1279","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Predictive Model to Evaluate the HbeAg Positivity of Chronic Hepatitis B Virus Patients in Clinics: A Cross-Sectional Study"],"prefix":"10.3390","volume":"58","author":[{"given":"Ning","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Liver Surgery, Liver Transplantation Center, West China Hospital of Sichuan University, Chengdu 610000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinli","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Liver Surgery, Liver Transplantation Center, West China Hospital of Sichuan University, Chengdu 610000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Liver Surgery, Liver Transplantation Center, West China Hospital of Sichuan University, Chengdu 610000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xingyu","family":"Pu","sequence":"additional","affiliation":[{"name":"Department of Liver Surgery, Liver Transplantation Center, West China Hospital of Sichuan University, Chengdu 610000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Liver Surgery, Liver Transplantation Center, West China Hospital of Sichuan University, Chengdu 610000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiayin","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Liver Surgery, Liver Transplantation Center, West China Hospital of Sichuan University, Chengdu 610000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,9,15]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization (2022, June 24). 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