{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T02:43:47Z","timestamp":1790045027603,"version":"4.0.1"},"reference-count":38,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2022,9,23]],"date-time":"2022-09-23T00:00:00Z","timestamp":1663891200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"CNCS-UEFISCDI of the Ministry of Research, Innovation, and Digitization","award":["PN-III-P1-1.1-TE-2021-0531"],"award-info":[{"award-number":["PN-III-P1-1.1-TE-2021-0531"]}]},{"name":"CNCS-UEFISCDI of the Ministry of Research, Innovation, and Digitization","award":["881\/13\/12.01.2022"],"award-info":[{"award-number":["881\/13\/12.01.2022"]}]},{"name":"the Doctoral Research Project (PCD 2022) of the Iuliu Ha\u0163ieganu University of Medicine and Pharmacy, Cluj-Napoca","award":["PN-III-P1-1.1-TE-2021-0531"],"award-info":[{"award-number":["PN-III-P1-1.1-TE-2021-0531"]}]},{"name":"the Doctoral Research Project (PCD 2022) of the Iuliu Ha\u0163ieganu University of Medicine and Pharmacy, Cluj-Napoca","award":["881\/13\/12.01.2022"],"award-info":[{"award-number":["881\/13\/12.01.2022"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: Vitamin D (Vit. D) is known for its role in the skeletal system. Vit. D deficiency is also widely researched for its effects on the healing of fractures, bone defects, and osseointegration of implants. In the literature, there are studies that investigated the effects of dietary supplementation with Vit. D to reduce Vit. D deficiency, but increasing the serum level of this vitamin takes time. Therefore, an attempt has been made to combat the effect of Vit. D deficiency through topical applications. The aim of this article was to conduct a review of the existing bibliographic data that investigate the effect of Vit. D on bone regeneration. Materials and Methods: In order to carry out this review, an electronic search was made in several databases and the articles found were selected and analyzed. Results: The in vitro studies\u2019 results demonstrated that Vit. D has a high therapeutic potential by enhancing the differentiation of stem cells in osteoblasts. Human and animal studies were conducting using various methods, but most of them revealed that Vit. D has a positive influence on the process of bone regeneration. Conclusions: The overall results of the research showed that, indeed, Vit. D is beneficial for bone regeneration; however, most of the studies imply that a thorough research is still needed for finding the most effective mode of administration and the dose needed in order to achieve the desired effect.<\/jats:p>","DOI":"10.3390\/medicina58101337","type":"journal-article","created":{"date-parts":[[2022,9,26]],"date-time":"2022-09-26T01:41:58Z","timestamp":1664156518000},"page":"1337","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Effect of Vitamin D on Bone Regeneration: A Review"],"prefix":"10.3390","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3342-9383","authenticated-orcid":false,"given":"Giorgiana","family":"Muresan","sequence":"first","affiliation":[{"name":"Department of Oral Health, Iuliu Hatieganu University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mihaela","family":"Hedesiu","sequence":"additional","affiliation":[{"name":"Department of Oral Radiology, Iuliu Hatieganu University of Medicine and Pharmacy, 400006 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0092-8955","authenticated-orcid":false,"given":"Ondine","family":"Lucaciu","sequence":"additional","affiliation":[{"name":"Department of Oral Health, Iuliu Hatieganu University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9369-3488","authenticated-orcid":false,"given":"Sanda","family":"Boca","sequence":"additional","affiliation":[{"name":"Interdisciplinary Research Institute in Bio-Nano-Sciences, Babes-Bolyai University, 400271 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3450-1068","authenticated-orcid":false,"given":"Nausica","family":"Petrescu","sequence":"additional","affiliation":[{"name":"Department of Oral Health, Iuliu Hatieganu University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,9,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Funda, G., Taschieri, S., Bruno, G.A., Grecchi, E., Paolo, S., Girolamo, D., and Del Fabbro, M. 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