{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T11:38:35Z","timestamp":1765280315994,"version":"build-2065373602"},"reference-count":29,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2022,9,27]],"date-time":"2022-09-27T00:00:00Z","timestamp":1664236800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Ever since it was first described in 1760, acute type A aortic dissection has created difficulties in its management. The recent COVID-19 pandemic revealed that extrapulmonary manifestations of this condition may occur, and recent reports suggested that aortic dissection may be amongst them since it shares a common physiopathology, that is, hyper-inflammatory syndrome. Cardiac surgery with cardiopulmonary bypass in the setting of COVID-19-positive patients carries a high risk of postoperative respiratory failure. While the vast majority accept that management of type A aortic dissection requires urgent surgery and central aortic therapy, there are some reports that advocate for delaying surgery. In this situation, the risk of aortic rupture must be balanced with the possible benefits of delaying urgent surgery. We present a case of acute type A dissection with COVID-19-associated bronchopneumonia successfully managed after delaying surgery for 6 days.<\/jats:p>","DOI":"10.3390\/medicina58101357","type":"journal-article","created":{"date-parts":[[2022,9,28]],"date-time":"2022-09-28T01:51:49Z","timestamp":1664329909000},"page":"1357","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Delayed Surgical Management of Acute Type A Aortic Dissection in a Patient with Recent COVID-19 Infection and Post-COVID-19 Bronchopneumonia\u2014Case Report and Review of Literature"],"prefix":"10.3390","volume":"58","author":[{"given":"Mircea","family":"Robu","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Surgery, Prof. Dr. C.C. Iliescu Emergency Institute for Cardiovascular Diseases, 022322 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana Romina","family":"Marian","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Prof. Dr. C.C. Iliescu Emergency Institute for Cardiovascular Diseases, 022322 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rasvan","family":"Vasile","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Prof. Dr. C.C. Iliescu Emergency Institute for Cardiovascular Diseases, 022322 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bogdan","family":"Radulescu","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Prof. Dr. C.C. Iliescu Emergency Institute for Cardiovascular Diseases, 022322 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alice","family":"Stegaru","sequence":"additional","affiliation":[{"name":"Anesthesia and Intensive Care Department, Prof. Dr. C.C. Iliescu Emergency Institute for Cardiovascular Diseases, 022328 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristian","family":"Voica","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Clinical Emergency Hospital Bucharest, 014461 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Nica","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Clinical Emergency Hospital Bucharest, 014461 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3660-8926","authenticated-orcid":false,"given":"Daniela","family":"Gheorghita","sequence":"additional","affiliation":[{"name":"Faculty of Materials Science and Engineering, Politehnica University of Bucharest, 060042 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ondin","family":"Zaharia","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania"},{"name":"Prof. Dr. Theodor Burghele Clinical Hospital, 050659 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0112-3494","authenticated-orcid":false,"given":"Antoniac","family":"Iulian","sequence":"additional","affiliation":[{"name":"Faculty of Materials Science and Engineering, Politehnica University of Bucharest, 060042 Bucharest, Romania"},{"name":"Academy of Romanian Scientists, 54, Spl. Independentei, 050711 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angelica","family":"Moldovan","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Clinical Emergency Hospital Bucharest, 014461 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victor","family":"Pavel","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Clinical Emergency Hospital Bucharest, 014461 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2241-279X","authenticated-orcid":false,"given":"Horatiu","family":"Moldovan","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Clinical Emergency Hospital Bucharest, 014461 Bucharest, Romania"},{"name":"Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania"},{"name":"Academy of Romanian Scientists, 54, Spl. Independentei, 050711 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vlad Anton","family":"Iliescu","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Prof. Dr. C.C. Iliescu Emergency Institute for Cardiovascular Diseases, 022322 Bucharest, Romania"},{"name":"Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,9,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1007\/s12055-019-00837-8","article-title":"and Yadav, A. Medical therapy versus TEVAR for uncomplicated type B aortic dissection","volume":"35","author":"Bedi","year":"2019","journal-title":"Indian J. Thorac. Cardiovasc. Surg."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.ccl.2021.06.002","article-title":"Acute Aortic Syndromes","volume":"39","author":"Rogers","year":"2021","journal-title":"Cardiol Clin."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.1016\/j.hlc.2020.05.113","article-title":"Factors Affecting Outcomes in Acute Type A Aortic Dissection: A Systematic Review","volume":"29","author":"Harky","year":"2020","journal-title":"Heart Lung Circ."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1038\/s41591-020-0968-3","article-title":"Extrapulmonary manifestations of COVID-19","volume":"26","author":"Gupta","year":"2020","journal-title":"Nat. Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"155323","DOI":"10.1016\/j.cyto.2020.155323","article-title":"Cytokine profile and disease severity in patients with COVID-19","volume":"137","author":"Ghazavi","year":"2021","journal-title":"Cytokine"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1097\/CRD.0000000000000289","article-title":"Biomarkers of aortopathy in Marfan syndrome","volume":"28","author":"Iskandar","year":"2020","journal-title":"Cardiol. Rev."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1080\/10408363.2020.1770685","article-title":"Biomarkers associated with COVID-19 disease progression","volume":"57","author":"Ponti","year":"2020","journal-title":"Crit. Rev.Clin. Lab. Sci."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"185","DOI":"10.31925\/farmacia.2020.2.1","article-title":"A new era for the therapeutic management of the ongoing COVID-19 pandemic","volume":"68","author":"Arsene","year":"2020","journal-title":"Farmacia"},{"key":"ref_9","first-page":"101129","article-title":"Aortic dissection and COVID-19; a comprehensive systematic review","volume":"92","author":"Ramandi","year":"2022","journal-title":"Curr. Probl. Cardiol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"2873","DOI":"10.1093\/eurheartj\/ehu281","article-title":"2014 ESC Guidelines on the diagnosis and treatment of aortic diseases: Document covering acute and chronic aortic diseases of the thoracic and abdominal aorta of the adult The Task Force for the Diagnosis and Treatment of Aortic Diseases of the European Society of Cardiology (ESC)","volume":"35","author":"Erbel","year":"2014","journal-title":"Eur. Heart J."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/j.jtcvs.2018.11.127","article-title":"Managing patients with acute type A aortic dissection and mesenteric malperfusion syndrome: A 20-year experience","volume":"158","author":"Yang","year":"2019","journal-title":"J. Thorac. Cardiovasc. Surg."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.asjsur.2021.08.036","article-title":"Malperfusion in type A aortic dissection: One-staged hybrid treatment","volume":"45","author":"Song","year":"2022","journal-title":"Asian J. Surg."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1093\/eurheartj\/ehr186","article-title":"Management of acute aortic syndromes","volume":"33","author":"Nienaber","year":"2012","journal-title":"Eur. Heart J."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1161\/hc0202.102246","article-title":"Predicting death in patients with acute type A aortic dissection","volume":"105","author":"Mehta","year":"2002","journal-title":"Circulation"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1007\/s00392-020-01626-9","article-title":"Prevalence and impact of cardiovascular metabolic diseases on COVID-19 in China","volume":"109","author":"Li","year":"2020","journal-title":"Clin. Res. Cardiol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1001\/jama.2020.1585","article-title":"Clinical Characteristics of 138 Hospitalized Patients with 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China","volume":"323","author":"Wang","year":"2020","journal-title":"JAMA"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1111\/j.1365-2362.2009.02153.x","article-title":"SARS-coronavirus modulation of myocardial ACE2 expression and inflammation in patients with SARS","volume":"39","author":"Oudit","year":"2009","journal-title":"Eur. J. Clin. Investig."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1798","DOI":"10.1093\/eurheartj\/ehaa231","article-title":"Coronaviruses and the cardiovascular system: Acute and long-term implications","volume":"41","author":"Xiong","year":"2020","journal-title":"Eur. Heart J."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"2038","DOI":"10.1016\/j.ehj.2003.08.020","article-title":"Phenotypic variability of cardiovascular manifestations in Marfan Syndrome: Possible role of hyperhomocysteinemia and C677T MTHFR gene polymorphism","volume":"24","author":"Giusti","year":"2003","journal-title":"Eur. Heart J."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1002\/jmv.26235","article-title":"Matrix metalloproteinase 3 as a valuable marker for patients with COVID-19","volume":"93","author":"Shi","year":"2021","journal-title":"J. Med. Virol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1093\/infdis\/jiaa756","article-title":"Neutrophil more than platelet activation associates with thrombotic complications in COVID-19 patients","volume":"223","author":"Petito","year":"2020","journal-title":"J. Infect. Dis."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Cardiothoracic Interdisciplinary Research Network and COVIDSurg Collaborative (2021). Early outcomes and complications following cardiac surgery in patients testing positive for coronavirus disease 2019: An international cohort study. J. Thorac. Cardiovasc. Surg., 162, e355\u2013e372.","DOI":"10.1016\/j.jtcvs.2021.03.091"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"2486","DOI":"10.1111\/jocs.14918","article-title":"Asymptomatic patients with coronavirus disease and cardiac surgery: When should you operate?","volume":"35","author":"Surg","year":"2020","journal-title":"J. Card. Surg."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1734","DOI":"10.1016\/j.athoracsur.2020.08.008","article-title":"A Combination of Type A Aortic Dissection and COVID-19: Operative Mortality of 33%?","volume":"111","author":"Hwang","year":"2021","journal-title":"Ann. Thorac. Surg."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1177\/02676591211018983","article-title":"The assessment of patients undergoing cardiac surgery for COVID-19: Complications occurring during cardiopulmonary bypass","volume":"37","author":"Stammers","year":"2022","journal-title":"Perfusion"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"e017042","DOI":"10.1161\/JAHA.120.017042","article-title":"Cardiac surgery during the coronavirus disease 2019 pandemic: Perioperative considerations and triage recommendations","volume":"9","author":"Patel","year":"2020","journal-title":"J. Am. Heart Assoc."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1177\/1358863X15625371","article-title":"Malperfusion Syndromes in Aortic Dissection","volume":"21","author":"Crawford","year":"2016","journal-title":"Vasc. Med."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1016\/S0003-4975(97)01100-4","article-title":"Surgical delay for acute type A dissection with malperfusion","volume":"64","author":"Deeb","year":"1997","journal-title":"Ann. Thorac. Surg."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"e415","DOI":"10.1161\/CIRCULATIONAHA.109.879700","article-title":"Primary Cardiac Leiomyosarcoma When Valvular Disease Becomes a Vascular Surgical Emergency","volume":"121","author":"Jurcut","year":"2010","journal-title":"Circulation"}],"container-title":["Medicina"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1648-9144\/58\/10\/1357\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:40:39Z","timestamp":1760143239000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1648-9144\/58\/10\/1357"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,27]]},"references-count":29,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2022,10]]}},"alternative-id":["medicina58101357"],"URL":"https:\/\/doi.org\/10.3390\/medicina58101357","relation":{},"ISSN":["1648-9144"],"issn-type":[{"type":"electronic","value":"1648-9144"}],"subject":[],"published":{"date-parts":[[2022,9,27]]}}}