{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T18:21:28Z","timestamp":1779906088293,"version":"3.53.1"},"reference-count":26,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2022,9,28]],"date-time":"2022-09-28T00:00:00Z","timestamp":1664323200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004606","name":"Chang Gung Memorial Hospital","doi-asserted-by":"publisher","award":["CRRPG3M0071"],"award-info":[{"award-number":["CRRPG3M0071"]}],"id":[{"id":"10.13039\/501100004606","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004606","name":"Chang Gung Memorial Hospital","doi-asserted-by":"publisher","award":["MOST 110-2221-E-182A-006-"],"award-info":[{"award-number":["MOST 110-2221-E-182A-006-"]}],"id":[{"id":"10.13039\/501100004606","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology","doi-asserted-by":"publisher","award":["CRRPG3M0071"],"award-info":[{"award-number":["CRRPG3M0071"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology","doi-asserted-by":"publisher","award":["MOST 110-2221-E-182A-006-"],"award-info":[{"award-number":["MOST 110-2221-E-182A-006-"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>We aimed to describe the use of topical ascorbic acid (AA) in a patient with reduced endothelial cells density (ECD) who was scheduled for phakic intraocular lens (pIOL) implantation. A 28-year-old woman presenting with dry eye and reduced ECD would like to have her high myopia (spherical equivalence &gt;\u221215.0 D) corrected. The procedure of laser refractive surgery or even pIOL was not indicated for the reduced ECD of 1865\/mm2 in the right eye and 2188\/mm2 in the left eye, as well as level 3 dry eye. Fortunately, the ECD increased to 3144\/mm2 in the right eye and 2538\/mm2 in the left eye after topical AA was prescribed for one year preoperatively and one month postoperatively, with concomitant improvement of dry eye to level 1. Finally, bilateral pIOL implantation was performed smoothly and no sign of corneal decompensation was found postoperatively. Three months postoperatively, the ECD showed a satisfactory level of 2983\/mm2 in the right eye and 3003\/mm2 in the left eye. In conclusion, topical AA instillation might increase and maintain the density of central human corneal endothelial cells (HCECs) even after pIOL implantation.<\/jats:p>","DOI":"10.3390\/medicina58101367","type":"journal-article","created":{"date-parts":[[2022,9,28]],"date-time":"2022-09-28T22:53:19Z","timestamp":1664405599000},"page":"1367","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Successful Phakic Intraocular Lens Implantation with the Usage of Topical Ascorbic Acid in Patient with Reduced Corneal Endothelial Cell Density"],"prefix":"10.3390","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1117-7878","authenticated-orcid":false,"given":"Hung-Chi","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Chang Gung Memorial Hospital, Linkou 333423, Taiwan"},{"name":"Department of Medicine, Chang Gung University College of Medicine, Taoyuan 33302, Taiwan"},{"name":"Center for Tissue Engineering, Chang Gung Memorial Hospital, Linkou 333423, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5719-0488","authenticated-orcid":false,"given":"Chia-Yi","family":"Lee","sequence":"additional","affiliation":[{"name":"Institute of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan"},{"name":"Nobel Eye Institute, Taipei 100008, Taiwan"},{"name":"Department of Ophthalmology, Jen-Ai Hospital Dali Branch, Taichung 41265, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8644-1960","authenticated-orcid":false,"given":"Chao-Min","family":"Cheng","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Engineering, National Tsing Hua University, Hsinchu 300044, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3380-7188","authenticated-orcid":false,"given":"Yi-Jen","family":"Hsueh","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Chang Gung Memorial Hospital, Linkou 333423, Taiwan"},{"name":"Center for Tissue Engineering, Chang Gung Memorial Hospital, Linkou 333423, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao-Kai","family":"Chang","sequence":"additional","affiliation":[{"name":"Nobel Eye Institute, Taipei 100008, Taiwan"},{"name":"Department of Optometry, Yuanpei University of Medical Technology, Hsinchu 30015, Taiwan"},{"name":"Department of Optometry, Da-Yeh University, Chunghua 51500, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Chi","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Chang Gung Memorial Hospital, Linkou 333423, Taiwan"},{"name":"Department of Medicine, Chang Gung University College of Medicine, Taoyuan 33302, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,9,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2244","DOI":"10.1016\/j.ophtha.2009.08.018","article-title":"Phakic intraocular lens implantation for the correction of myopia: A report by the american academy of ophthalmology","volume":"116","author":"Huang","year":"2009","journal-title":"Ophthalmology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1016\/j.jcrs.2013.04.035","article-title":"Collagen copolymer posterior chamber phakic intraocular lens for hyperopia correction: Three-year follow-up","volume":"39","author":"Alfonso","year":"2013","journal-title":"J. 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