{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T04:43:48Z","timestamp":1760244228462,"version":"build-2065373602"},"reference-count":23,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2022,9,29]],"date-time":"2022-09-29T00:00:00Z","timestamp":1664409600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>A forty-seven-year-old recipient in late period after kidney transplantation with chronic estimated glomerular filtration rate (eGFR) 30 mL\/min\/1.73 m2, fully vaccinated against COVID-19 was diagnosed with SARS-CoV-2 infection in November 2021. After an initially mild course of the disease, he developed multiorgan failure requiring periodic respiratory and dialysis therapy. Covid-19 disease was complicated by multiple infections such Clostridioides difficile infection, Streptococcus epidermidis bacteriemia, Klebsiella pneumoniae and Candida glabrata urinary tract disease, cytomegalovirus infection and oral candidiasis. In a short period, he was readmitted to the hospital twice with recurrent Klebsiella pneumoniae urosepsis. One of those hospitalizations was also complicated by another COVID-19 infection that was confirmed with non-reactive neutralizing antibody. Due to severe infections the patient required individualized modification of immunotherapy; however, due to their recurrence it was finally decided to be discontinued. The patient was also reintroduced to hemodialysis therapy and no infections occurred since then.<\/jats:p>","DOI":"10.3390\/medicina58101370","type":"journal-article","created":{"date-parts":[[2022,9,29]],"date-time":"2022-09-29T23:09:29Z","timestamp":1664492969000},"page":"1370","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Multiple Post-SARS-COV2 Infectious Complications in Kidney Transplant Recipient"],"prefix":"10.3390","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8910-3513","authenticated-orcid":false,"given":"Patrycja","family":"Grzejszczak","sequence":"first","affiliation":[{"name":"Department of Internal Medicine and Transplant Nephrology, Medical University of Lodz, 90-153 Lodz, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agnieszka","family":"P\u0142uciennik","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Barlicki Memorial Teaching Hospital No. 1, 90-153 Lodz, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Kumor-Kisielewska","sequence":"additional","affiliation":[{"name":"Department of Pathobiology of Respiratory Diseases, Medical University of Lodz, 90-153 Lodz, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3448-0682","authenticated-orcid":false,"given":"Ilona","family":"Kurnatowska","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Transplant Nephrology, Medical University of Lodz, 90-153 Lodz, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,9,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1590\/2175-8239-jbn-2018-0002-0003","article-title":"Understanding the causes of mortality post-transplantation\u2014There is more than meets the eye","volume":"40","author":"Riella","year":"2018","journal-title":"J. Bras. Nefrol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2601","DOI":"10.1056\/NEJMra064928","article-title":"Infection in solid-organ transplant recipients","volume":"357","author":"Fishman","year":"2007","journal-title":"N. Engl. J. Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1111\/ajt.14208","article-title":"Infection in organ transplantation","volume":"17","author":"Fishman","year":"2017","journal-title":"Am. J. Transplant."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"3140","DOI":"10.1111\/ajt.16185","article-title":"COVID-19 and Kidney Transplantation: Results from the TANGO International Transplant Consortium","volume":"20","author":"Cravedi","year":"2020","journal-title":"Am. J. Transplant."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"2475","DOI":"10.1056\/NEJMc2011117","article-title":"COVID-19 and Kidney Transplantation","volume":"18","author":"Akalin","year":"2020","journal-title":"N. Engl. J. Med."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"e13378","DOI":"10.1111\/tid.13378","article-title":"COVID-19 pneumonia in kidney transplant recipients: Focus on immunosuppression management","volume":"22","author":"Chen","year":"2020","journal-title":"Transpl. Infect. Dis."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1973","DOI":"10.1093\/ndt\/gfaa261","article-title":"COVID-19-related mortality in kidney transplant and dialysis patients: Results of the ERACODA collaboration","volume":"35","author":"Hilbrands","year":"2020","journal-title":"Nephrol. Dial. Transplant."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Tylicki, L., D\u0119bska-\u015alizie\u0144, A., Muchlado, M., \u015alizie\u0144, Z., Go\u0142\u0119biewska, J., D\u0105browska, M., and Biedunkiewicz, B. (2021). Boosting Humoral Immunity from mRNA COVID-19 Vaccines in Kidney Transplant Recipients. Vaccines, 31.","DOI":"10.3390\/vaccines10010056"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"e1292","DOI":"10.1097\/TXD.0000000000001292","article-title":"Immunosuppression and SARS-CoV-2 Infection in Kidney Transplant Recipients","volume":"8","author":"Devresse","year":"2022","journal-title":"Transplant. Direct"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1819","DOI":"10.1111\/ajt.15967","article-title":"COVID-19 in kidney transplant recipients","volume":"20","author":"Nair","year":"2020","journal-title":"Am. J. Transplant."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1016\/S0140-6736(20)30566-3","article-title":"Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: A retrospective cohort study","volume":"395","author":"Zhou","year":"2020","journal-title":"Lancet"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2642","DOI":"10.1016\/j.transproceed.2020.09.006","article-title":"Effects of Coronavirus Disease 2019 on Solid Organ Transplantation","volume":"52","author":"Aziz","year":"2020","journal-title":"Transplant. Proc."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"2958","DOI":"10.1111\/ajt.15970","article-title":"Preliminary data on outcomes of SARS-CoV-2 infection in a Spanish single center cohort of kidney recipients","volume":"20","author":"Cofan","year":"2020","journal-title":"Am. J. Transplant."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0140-6736(20)30183-5","article-title":"Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China","volume":"15","author":"Huang","year":"2020","journal-title":"Lancet"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"3182","DOI":"10.1111\/ajt.16192","article-title":"Spanish Society of Nephrology COVID-19 Group. Use of tocilizumab in kidney transplant recipients with COVID-19","volume":"20","author":"Blasco","year":"2020","journal-title":"Am. J. Transplant."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/s41392-020-0148-4","article-title":"Lymphopenia predicts disease severity of COVID-19: A descriptive and predictive study","volume":"27","author":"Tan","year":"2020","journal-title":"Signal. Transduct. Target. Ther."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/0091-6749(78)90200-2","article-title":"Monocyte cellular function in asthmatic patients on alternate-day steroid therapy","volume":"61","author":"Norris","year":"1978","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1136\/bmjebm-2020-111536","article-title":"Biomarkers and outcomes of COVID-19 hospitalizations: Systematic review and meta-analysis","volume":"26","author":"Malik","year":"2021","journal-title":"BMJ Evid.-Based Med."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"e13759","DOI":"10.1111\/tid.13759","article-title":"Monoclonal antibody treatment for COVID-19 in solid organ transplant recipients","volume":"24","author":"Sarrell","year":"2022","journal-title":"Transpl. Infect. Dis."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/s40472-022-00368-z","article-title":"Evolution of Clinical Care in COVID-Infected Solid Organ Transplant Recipients","volume":"9","author":"Sigler","year":"2022","journal-title":"Curr. Transplant. Rep."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1515\/cclm-2021-0313","article-title":"Analytical and clinical performances of a SARS-CoV-2 S-RBD IgG assay: Comparison with neutralization titers","volume":"14","author":"Padoan","year":"2021","journal-title":"Clin. Chem. Lab. Med."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cca.2020.05.050","article-title":"Diagnostic performances and thresholds: The key to harmonization in serological SARS-CoV-2 assays","volume":"509","author":"Plebani","year":"2020","journal-title":"Clin. Chim. Acta"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"e13421","DOI":"10.1111\/tid.13421","article-title":"COVID-19 in solid organ transplant recipients: No difference in survival compared to general population","volume":"23","author":"Rinaldi","year":"2021","journal-title":"Transpl. Infect. Dis."}],"container-title":["Medicina"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1648-9144\/58\/10\/1370\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:41:46Z","timestamp":1760143306000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1648-9144\/58\/10\/1370"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,29]]},"references-count":23,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2022,10]]}},"alternative-id":["medicina58101370"],"URL":"https:\/\/doi.org\/10.3390\/medicina58101370","relation":{},"ISSN":["1648-9144"],"issn-type":[{"type":"electronic","value":"1648-9144"}],"subject":[],"published":{"date-parts":[[2022,9,29]]}}}