{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T12:53:08Z","timestamp":1789563188076,"version":"build-2803163510"},"reference-count":27,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2022,10,2]],"date-time":"2022-10-02T00:00:00Z","timestamp":1664668800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Zhejiang Provincial Basic-Public-Welfare Planning Project","award":["LQ22H230001"],"award-info":[{"award-number":["LQ22H230001"]}]},{"name":"Zhejiang Provincial Basic-Public-Welfare Planning Project","award":["2022KY1256"],"award-info":[{"award-number":["2022KY1256"]}]},{"name":"Zhejiang Provincial Basic-Public-Welfare Planning Project","award":["2021ZB288"],"award-info":[{"award-number":["2021ZB288"]}]},{"name":"Zhejiang Provincial Basic-Public-Welfare Planning Project","award":["H201550"],"award-info":[{"award-number":["H201550"]}]},{"name":"Zhejiang Provincial Medical and Health Sci-Tech Plan Project","award":["LQ22H230001"],"award-info":[{"award-number":["LQ22H230001"]}]},{"name":"Zhejiang Provincial Medical and Health Sci-Tech Plan Project","award":["2022KY1256"],"award-info":[{"award-number":["2022KY1256"]}]},{"name":"Zhejiang Provincial Medical and Health Sci-Tech Plan Project","award":["2021ZB288"],"award-info":[{"award-number":["2021ZB288"]}]},{"name":"Zhejiang Provincial Medical and Health Sci-Tech Plan Project","award":["H201550"],"award-info":[{"award-number":["H201550"]}]},{"name":"Zhejiang Provincial TCM Sci-Tech Project","award":["LQ22H230001"],"award-info":[{"award-number":["LQ22H230001"]}]},{"name":"Zhejiang Provincial TCM Sci-Tech Project","award":["2022KY1256"],"award-info":[{"award-number":["2022KY1256"]}]},{"name":"Zhejiang Provincial TCM Sci-Tech Project","award":["2021ZB288"],"award-info":[{"award-number":["2021ZB288"]}]},{"name":"Zhejiang Provincial TCM Sci-Tech Project","award":["H201550"],"award-info":[{"award-number":["H201550"]}]},{"name":"Jiangsu Provincial Medical and Health Sci-Tech Plan Project","award":["LQ22H230001"],"award-info":[{"award-number":["LQ22H230001"]}]},{"name":"Jiangsu Provincial Medical and Health Sci-Tech Plan Project","award":["2022KY1256"],"award-info":[{"award-number":["2022KY1256"]}]},{"name":"Jiangsu Provincial Medical and Health Sci-Tech Plan Project","award":["2021ZB288"],"award-info":[{"award-number":["2021ZB288"]}]},{"name":"Jiangsu Provincial Medical and Health Sci-Tech Plan Project","award":["H201550"],"award-info":[{"award-number":["H201550"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: To compare the oncological and functional outcomes of brachytherapy (BT) and radical prostatectomy (RP) in patients with localized prostate cancer (PCa). Materials and Methods: We retrospectively analyzed data from 557 patients with localized PCa who were treated with BT (n = 245) or RP (n = 312) at Northern Jiangsu People\u2019s Hospital between January 2012 and December 2017. Biochemical relapse-free survival (bRFS) and cancer-specific survival (CSS) were compared by treatment modality. Multivariate Cox regression analysis was used to evaluate bRFS. Health-related quality of life (HRQoL) was measured using the Expanded Prostate Cancer Index Composite (EPIC) questionnaire. Results: The BT group was older and had a higher initial PSA (iPSA). The 5-year bRFS was 82.9% in the BT group versus 80.1% in the RP group (p = 0.570). The 5-year CSS was 96.4% in the BT group versus 96.8% in the RP group (p = 0.967). Based on multivariate Cox regression analysis, Gleason score \u2265 8 was the main independent prognostic factor for bRFS. Regarding the HRQoL, compared with the baseline, both treatments produced a significant decrease in different aspects of HRQoL at 3, 6, and 12 months after treatment. Patients in the BT group had lower HRQoL with regard to urinary irritation\/obstruction and bowel function or bother, while patients in the RP group had lower HRQoL concerning urinary incontinence and sexual function or bother. There was no significant difference in HRQoL aspects between the two groups after follow-up for 2 years compared with the baseline. Conclusions: BT provides equivalent oncological control outcomes in terms of bRFS and CSS for patients with localized PCa compared with RP. Gleason score \u2265 8 was the main independent prognostic factor for bRFS. BT had better HRQoL compared with RP, except for urinary irritation\/obstruction and bowel function or bother, but returned to baseline after 2 years.<\/jats:p>","DOI":"10.3390\/medicina58101387","type":"journal-article","created":{"date-parts":[[2022,10,9]],"date-time":"2022-10-09T04:00:02Z","timestamp":1665288002000},"page":"1387","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Comparison of the Oncological and Functional Outcomes of Brachytherapy and Radical Prostatectomy for Localized Prostate Cancer"],"prefix":"10.3390","volume":"58","author":[{"given":"Fei","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Urology, Municipal Key-Innovative Discipline, The Second Affiliated Hospital of Jiaxing University, Jiaxing 314001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Luan","sequence":"additional","affiliation":[{"name":"Department of Urology, Northern Jiangsu People\u2019s Hospital, Yangzhou 225001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaqin","family":"Fan","sequence":"additional","affiliation":[{"name":"Departments of Oncology, The First Affiliated Hospital of Jiaxing University, Jiaxing 314001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianbao","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Urology, Northern Jiangsu People\u2019s Hospital, Yangzhou 225001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangyong","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Urology, Northern Jiangsu People\u2019s Hospital, Yangzhou 225001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengming","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Urology, Northern Jiangsu People\u2019s Hospital, Yangzhou 225001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huazhi","family":"Tao","sequence":"additional","affiliation":[{"name":"Department of Urology, Northern Jiangsu People\u2019s Hospital, Yangzhou 225001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Sheng","sequence":"additional","affiliation":[{"name":"Department of Urology, Jiaxing Hospital of Traditional Chinse Medicine, Jiaxing University, Jiaxing 314001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6827-2120","authenticated-orcid":false,"given":"Deqing","family":"Chen","sequence":"additional","affiliation":[{"name":"Forensic and Pathology Laboratory, Provincial Key Laboratory of Medical Electronics and Digital Health, Institute of Forensic Science, Jiaxing University, Jiaxing 314001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuefei","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Urology, Northern Jiangsu People\u2019s Hospital, Yangzhou 225001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3322\/caac.21708","article-title":"Cancer statistics, 2022","volume":"72","author":"Siegel","year":"2022","journal-title":"CA Cancer J. 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