{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T07:42:43Z","timestamp":1762069363474,"version":"build-2065373602"},"reference-count":19,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2022,10,10]],"date-time":"2022-10-10T00:00:00Z","timestamp":1665360000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: The hemoadsorption device CytoSorb\u00ae (CytoSorbents Inc., Princeton, NJ, USA) has been shown to efficiently remove ticagrelor from whole blood in vitro. A promising clinical experience was made with the integration of the hemoadsorption cartridge on the cardiopulmonary bypass (CPB) circuit during cardiac surgery to reduce adverse events. Materials and Methods: In this report, we describe a novel approach using a new apheresis platform, PUR-01 (Nikkisio Co., Ltd., Tokyo, Japan), which was used as the extracorporeal circuit where CytoSorb\u00ae could be installed for the removal of ticagrelor during off-pump coronary artery bypass (OPCAB) procedures. Results: In a 74-year-old male (index case) with coronary artery disease and dual antiplatelet therapy, hemoadsorption was initiated with a skin incision for OPCAB surgery and was continued for 221 min to eliminate ticagrelor. The blood volume that had circulated through the CytoSorb\u00ae was 39.04 L in total. Thus far, this treatment strategy has been used in four cases with CHD and DAPT who needed OPCAB surgery. The intraoperative and postoperative courses were uneventful in all patients. No device-related adverse events occurred. Conclusions: The combination of the PUR-01 apheresis pump and hemoadsorption with the CytoSorb\u00ae column during OPCAB procedures appears to be safe and effective in eliminating antiplatelet drugs.<\/jats:p>","DOI":"10.3390\/medicina58101427","type":"journal-article","created":{"date-parts":[[2022,10,10]],"date-time":"2022-10-10T21:07:11Z","timestamp":1665436031000},"page":"1427","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A New Apheresis Device for Antithrombotic Drug Removal during Off-Pump Coronary Artery Bypass Surgery"],"prefix":"10.3390","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5946-0891","authenticated-orcid":false,"given":"Helmut","family":"Mair","sequence":"first","affiliation":[{"name":"Department of Cardiac Surgery, Artemed Klinikum M\u00fcnchen S\u00fcd, 81379 Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norman","family":"Micka","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Artemed Klinikum M\u00fcnchen S\u00fcd, 81379 Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1924-6823","authenticated-orcid":false,"given":"Ferdinand","family":"Vogt","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Artemed Klinikum M\u00fcnchen S\u00fcd, 81379 Munich, Germany"},{"name":"Department of Cardiac Surgery, Paracelsus Medical University, 40791 Nuremberg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dow","family":"Rosenzweig","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Artemed Klinikum M\u00fcnchen S\u00fcd, 81379 Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"Vogel","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Artemed Klinikum M\u00fcnchen S\u00fcd, 81379 Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benedikt","family":"Baumer","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Artemed Klinikum M\u00fcnchen S\u00fcd, 81379 Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie","family":"Ulrich","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Benedictus Krankenhaus Tutzing, 82327 Tutzing, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Lamm","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Artemed Klinikum M\u00fcnchen S\u00fcd, 81379 Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e000651","DOI":"10.1136\/openhrt-2017-000651","article-title":"Dual antiplatelet therapy for secondary prevention of coronary artery disease","volume":"4","author":"Degrauwe","year":"2017","journal-title":"Open Heart"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"e008226","DOI":"10.1161\/CIRCINTERVENTIONS.119.008226","article-title":"Bleeding Risk, Dual Antiplatelet Therapy Cessation, and Adverse Events After Percutaneous Coronary Intervention: The PARIS Registry","volume":"13","author":"Sorrentino","year":"2020","journal-title":"Circ. 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