{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,30]],"date-time":"2025-11-30T09:17:36Z","timestamp":1764494256145,"version":"build-2065373602"},"reference-count":58,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2022,10,15]],"date-time":"2022-10-15T00:00:00Z","timestamp":1665792000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Monkeypox (MPX) is a zoonotic infection caused by an orthopoxvirus that is endemic to Central and Western Africa. The MPX virus is a part of the same family of viruses as the variola virus, which causes smallpox. Since May 2022, there has been a global increase in the incidence of MPX infections in multiple countries where the illness is not usually prevalent. A growing number of publications have emphasized on the need for increased awareness among all health professionals for the rapid recognition and diagnosis of this disease and for proper public health measures. However, atypical presentations and occurrence of uncommon symptoms receive less than the desired attention. More specifically, MPX infection related nociceptive symptoms are currently underexposed. Nevertheless, reports from the current outbreak have revealed that (severe) pain is one of the major causes for distress and even hospitalization in these patients. As for all serious pain conditions, an integrated, multidisciplinary, and holistic approach is indicated. This approach should be multimodal and include non-pharmacological therapies alongside pharmacological approaches. Health care professionals should be aware of available alternatives when first choice analgesic therapies fail. Protocols for identification of pain type and prolonged monitoring of clinical status should be implemented to improve patient well-being during acute infection, but also prevent chronic nociceptive syndromes.<\/jats:p>","DOI":"10.3390\/medicina58101454","type":"journal-article","created":{"date-parts":[[2022,10,17]],"date-time":"2022-10-17T02:29:46Z","timestamp":1665973786000},"page":"1454","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Integrated Analgesic Care in the Current Human Monkeypox Outbreak: Perspectives on an Integrated and Holistic Approach Combining Old Allies with Innovative Technologies"],"prefix":"10.3390","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4522-9055","authenticated-orcid":false,"given":"Guy Henri","family":"Hans","sequence":"first","affiliation":[{"name":"Antwerp University Hospital (UZA), Multidisciplinary Pain Center (PCT), Drie Eikenstraat 655, 2650 Edegem, Belgium"},{"name":"Faculty of Medicine and Health Sciences, University of Antwerp (UA), 2610 Antwerp, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Davina","family":"Wildemeersch","sequence":"additional","affiliation":[{"name":"Antwerp University Hospital (UZA), Multidisciplinary Pain Center (PCT), Drie Eikenstraat 655, 2650 Edegem, Belgium"},{"name":"Faculty of Medicine and Health Sciences, University of Antwerp (UA), 2610 Antwerp, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ine","family":"Meeus","sequence":"additional","affiliation":[{"name":"Antwerp University Hospital (UZA), Multidisciplinary Pain Center (PCT), Drie Eikenstraat 655, 2650 Edegem, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1093\/infdis\/124.1.33","article-title":"Induction, course, and transmissibility of monkeypox in the baboon (Papio cynocephalus)","volume":"124","author":"Heberling","year":"1971","journal-title":"J. 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