{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T23:23:30Z","timestamp":1775604210154,"version":"3.50.1"},"reference-count":22,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2022,10,18]],"date-time":"2022-10-18T00:00:00Z","timestamp":1666051200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: The aim of this paper is to evaluate the impact of humoral substance mid-regional pro-adrenomedullin (MR-proADM) on the two-year survival of patients with chronic heart failure and relate it to the dosage of furosemide. Materials and Methods: The data is taken from the stable systolic heart failure (EF &lt; 50%) FAR NHL registry (FARmacology and NeuroHumoraL activation). The primary endpoint at two-year follow-up was death, heart transplantation, or LVAD implantation. Results: A total of 1088 patients were enrolled in the FAR NHL registry; MR-proADM levels were available for 569 of them. The mean age was 65 years, and 81% were male. The aetiology of HF was ischemic heart disease in 53% and dilated cardiomyopathy in 41% of patients. The mean EF was 31 \u00b1 9%. Statistically significant differences (p &lt; 0.001) were obtained in several parameters: patients with higher MR-proADM levels were older, rated higher in NYHA class, suffered more often from lower limb oedema, and had more comorbidities such as hypertension, atrial fibrillation, diabetes, and renal impairment. MR-proADM level was related to furosemide dose. Patients taking higher doses of diuretics had higher MR-proADM levels. The mean MR-proADM level without furosemide (n = 122) was 0.62 (\u00b10.55) nmol\/L, with low dose (n = 113) 1\u201339 mg\/day was 0.67 (\u00b10.30) nmol\/L, with mid dose (n = 202) 40\u201379 mg\/day was 0.72 (\u00b10.34) nmol\/L, with high dose (n = 58) 80\u2013119 mg\/day was 0.85 (\u00b10.40) nmol\/L, and with maximum dose (n = 74) \u2265120 mg\/day was 1.07 (\u00b10.76) nmol\/L, p &lt; 0.001. Patients with higher MR-proADM levels were more likely to achieve the primary endpoint at a two-year follow-up (p &lt; 0.001) according to multivariant analysis. Conclusions: Elevated plasma MR-proADM levels in patients with chronic heart failure are associated with an increased risk of death and hospitalization. Higher MR-proADM levels in combination with increased use of loop diuretics reflect residual congestion and are associated with a higher risk of severe disease progression.<\/jats:p>","DOI":"10.3390\/medicina58101477","type":"journal-article","created":{"date-parts":[[2022,10,19]],"date-time":"2022-10-19T00:58:51Z","timestamp":1666141131000},"page":"1477","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Relation between Mid-Regional Pro-Adrenomedullin in Patients with Chronic Heart Failure and the Dose of Diuretics in 2-Year Follow-Up\u2014Data from FAR NHL Registry"],"prefix":"10.3390","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3291-5160","authenticated-orcid":false,"given":"Monika","family":"\u0160pinarov\u00e1","sequence":"first","affiliation":[{"name":"First Department of Internal Medicine\u2014Cardioangiology, St. Anne\u2019s University Hospital, Faculty of Medicine, Masaryk University, 625 00 Brno, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jind\u0159ich","family":"\u0160pinar","sequence":"additional","affiliation":[{"name":"First Department of Internal Medicine\u2014Cardioangiology, St. Anne\u2019s University Hospital, Faculty of Medicine, Masaryk University, 625 00 Brno, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5644-6720","authenticated-orcid":false,"given":"Lenka","family":"\u0160pinarov\u00e1","sequence":"additional","affiliation":[{"name":"First Department of Internal Medicine\u2014Cardioangiology, St. Anne\u2019s University Hospital, Faculty of Medicine, Masaryk University, 625 00 Brno, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Krej\u010d\u00ed","sequence":"additional","affiliation":[{"name":"First Department of Internal Medicine\u2014Cardioangiology, St. Anne\u2019s University Hospital, Faculty of Medicine, Masaryk University, 625 00 Brno, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monika","family":"Goldbergov\u00e1-P\u00e1vkov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Pathological Physiology, Faculty of Medicine, Masaryk University, 625 00 Brno, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji\u0159\u00ed","family":"Pa\u0159enica","sequence":"additional","affiliation":[{"name":"Department of Internal Cardiology Medicine, Faculty Hospital Brno, Faculty of Medicine, Masaryk University, 625 00 Brno, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ond\u0159ej","family":"Ludka","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Geriatrics and Practical Medicine, Faculty Hospital Brno, Faculty of Medicine, Masaryk University, 625 00 Brno, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Filip","family":"M\u00e1lek","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Na Homolce Hospital, 150 00 Prague, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petr","family":"O\u0161\u0165\u00e1dal","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Na Homolce Hospital, 150 00 Prague, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kl\u00e1ra","family":"Bene\u0161ov\u00e1","sequence":"additional","affiliation":[{"name":"Institute of Biostatistics and Analyses, Faculty of Medicine, Masaryk University, 625 00 Brno, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji\u0159\u00ed","family":"Jarkovsk\u00fd","sequence":"additional","affiliation":[{"name":"Institute of Biostatistics and Analyses, Faculty of Medicine, Masaryk University, 625 00 Brno, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4738-8044","authenticated-orcid":false,"given":"Karel","family":"L\u00e1br","sequence":"additional","affiliation":[{"name":"First Department of Internal Medicine\u2014Cardioangiology, St. Anne\u2019s University Hospital, Faculty of Medicine, Masaryk University, 625 00 Brno, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"3599","DOI":"10.1093\/eurheartj\/ehab368","article-title":"2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure","volume":"42","author":"McDonagh","year":"2021","journal-title":"Eur. 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