{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T10:21:17Z","timestamp":1787653277858,"version":"build-2736575974"},"reference-count":51,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2022,10,18]],"date-time":"2022-10-18T00:00:00Z","timestamp":1666051200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: The research aimed at evaluating the capacity of salivary exosomal miR-10b-5p and miR-486-5p for oral and oropharyngeal cancer detection. Materials and Methods: The saliva samples were harvested from histopathological diagnosed oral and oropharyngeal squamous cell carcinoma patients and healthy volunteer subjects. The exosomes were isolated by differential ultracentrifugation and quantified by Nano Track Analysis. The microRNAs were extracted and quantified from salivary exosomes by quantitative Real-Time Polymerase Chain Reaction. Results: This research comprised fifty participants. When compared to healthy controls, salivary exosomal miR-486-5p was elevated and miR-10b-5p was reduced in oral and oropharyngeal squamous cell carcinoma. Moreover, miR-486-5p had a high expression level in stage II of cancer in comparison to the other cancer stages. The cancer samples presented an increased exosome dimension compared to the control samples. Conclusions: Salivary exosomal miR-10b-5p and miR-486-5p have an altered expression in oral and oropharyngeal cancer.<\/jats:p>","DOI":"10.3390\/medicina58101478","type":"journal-article","created":{"date-parts":[[2022,10,19]],"date-time":"2022-10-19T00:58:51Z","timestamp":1666141131000},"page":"1478","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Salivary Exosomal MicroRNA-486-5p and MicroRNA-10b-5p in Oral and Oropharyngeal Squamous Cell Carcinoma"],"prefix":"10.3390","volume":"58","author":[{"given":"Cosmin Ioan","family":"Faur","sequence":"first","affiliation":[{"name":"Department of Maxillofacial Surgery and Radiology, Oral Radiology, \u201cIuliu Ha\u021bieganu\u201d University of Medicine and Pharmacy, 32 Clinicilor Street, 400006 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0620-2845","authenticated-orcid":false,"given":"Rare\u0219 C\u0103lin","family":"Roman","sequence":"additional","affiliation":[{"name":"Department of Maxillofacial Surgery and Radiology, Oral and Cranio-Maxillofacial Surgery, \u201cIuliu Ha\u021bieganu\u201d University of Medicine and Pharmacy, 33 Mo\u021bilor Street, 400001 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ancu\u021ba","family":"Jurj","sequence":"additional","affiliation":[{"name":"Research Center for Functional Genomics, Biomedicine and Translational Medicine, \u201cIuliu Ha\u021bieganu\u201d University of Medicine and Pharmacy, 23 Gheorghe Marinescu Street, 400337 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lajos","family":"Raduly","sequence":"additional","affiliation":[{"name":"Research Center for Functional Genomics, Biomedicine and Translational Medicine, \u201cIuliu Ha\u021bieganu\u201d University of Medicine and Pharmacy, 23 Gheorghe Marinescu Street, 400337 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8800-4935","authenticated-orcid":false,"given":"Oana","family":"Alm\u0103\u0219an","sequence":"additional","affiliation":[{"name":"Department of Prosthetic Dentistry and Dental Materials, \u201cIuliu Ha\u021bieganu\u201d University of Medicine and Pharmacy, 32 Clinicilor Street, 400006 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2138-3322","authenticated-orcid":false,"given":"Hora\u021biu","family":"Rotaru","sequence":"additional","affiliation":[{"name":"Department of Maxillofacial Surgery and Radiology, Oral and Cranio-Maxillofacial Surgery, \u201cIuliu Ha\u021bieganu\u201d University of Medicine and Pharmacy, 33 Mo\u021bilor Street, 400001 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena","family":"Chiril\u0103","sequence":"additional","affiliation":[{"name":"8th Department-Surgical Secialties, O.R.L., \u201cIuliu Ha\u021bieganu\u201d University of Medicine and Pharmacy, 4-6 Clinicilor Street, 400006 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6141-515X","authenticated-orcid":false,"given":"M\u0103d\u0103lina Anca","family":"Moldovan","sequence":"additional","affiliation":[{"name":"Department of Maxillofacial Surgery and Radiology, Oral and Cranio-Maxillofacial Surgery, \u201cIuliu Ha\u021bieganu\u201d University of Medicine and Pharmacy, 33 Mo\u021bilor Street, 400001 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mihaela","family":"Hede\u0219iu","sequence":"additional","affiliation":[{"name":"Department of Maxillofacial Surgery and Radiology, Oral Radiology, \u201cIuliu Ha\u021bieganu\u201d University of Medicine and Pharmacy, 32 Clinicilor Street, 400006 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristian","family":"Dinu","sequence":"additional","affiliation":[{"name":"Department of Maxillofacial Surgery and Radiology, Maxillofacial Surgery and Implantology, \u201cIuliu Ha\u021bieganu\u201d University of Medicine and Pharmacy, 37 Iuliu Hossu Street, 400429 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1038\/s41572-020-00224-3","article-title":"Head and Neck Squamous Cell Carcinoma","volume":"6","author":"Johnson","year":"2020","journal-title":"Nat. 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