{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T04:44:29Z","timestamp":1760244269787,"version":"build-2065373602"},"reference-count":14,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2022,10,19]],"date-time":"2022-10-19T00:00:00Z","timestamp":1666137600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: Atrial fibrillation (AF) is the most common sustained arrhythmia worldwide. The relationship between AF and iron deficiency is poorly understood. Materials and Methods: We conducted an observational study investigating the prevalence of iron deficiency in those with AF. Iron deficiency was defined by the American College of Cardiology (ACC) criteria for iron deficiency in heart failure. Results: Of 134 eligible subjects, 81 (60.4%) met the ACC definition of iron deficiency in heart failure. Those who were iron deficient were more likely to be female (OR 1.876, p = 0.005), have a history of diabetes mellitus (OR 3.085, p = 0.001) a history of stroke (OR 3.147, p = 0.016), and have higher CHA2DS2-VASc (p \u2264 0.0001) and Charlson Comorbidity Index scores (CCI) (p = 0.007). Conclusions: The prevalence of iron deficiency in those with AF appears high and warrants evaluation in a prospective study.<\/jats:p>","DOI":"10.3390\/medicina58101492","type":"journal-article","created":{"date-parts":[[2022,10,19]],"date-time":"2022-10-19T22:19:53Z","timestamp":1666217993000},"page":"1492","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Prevalence of Iron Deficiency in Atrial Fibrillation: Low Hanging Fruit?"],"prefix":"10.3390","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3372-1694","authenticated-orcid":false,"given":"Bachar","family":"Alabdullah","sequence":"first","affiliation":[{"name":"Cardiology Department, Tamworth Rural Referral Hospital, Dean Street, North Tamworth, NSW 2340, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3142-4503","authenticated-orcid":false,"given":"David","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Cardiovascular Department, John Hunter Hospital, New Lambton Heights, Newcastle, NSW 2305, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erin","family":"Bourke","sequence":"additional","affiliation":[{"name":"Cardiology Department, Tamworth Rural Referral Hospital, Dean Street, North Tamworth, NSW 2340, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harish","family":"Kamalanathan","sequence":"additional","affiliation":[{"name":"Cardiovascular Department, John Hunter Hospital, New Lambton Heights, Newcastle, NSW 2305, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ibrahim","family":"Elashri","sequence":"additional","affiliation":[{"name":"Cardiology Department, Tamworth Rural Referral Hospital, Dean Street, North Tamworth, NSW 2340, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kushal","family":"Porwal","sequence":"additional","affiliation":[{"name":"Cardiovascular Department, John Hunter Hospital, New Lambton Heights, Newcastle, NSW 2305, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael J.","family":"Tiller","sequence":"additional","affiliation":[{"name":"Cardiology Department, Tamworth Rural Referral Hospital, Dean Street, North Tamworth, NSW 2340, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Payal H.","family":"Gadre","sequence":"additional","affiliation":[{"name":"Cardiovascular Department, John Hunter Hospital, New Lambton Heights, Newcastle, NSW 2305, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Jones","sequence":"additional","affiliation":[{"name":"Cardiology Department, Tamworth Rural Referral Hospital, Dean Street, North Tamworth, NSW 2340, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9713-0826","authenticated-orcid":false,"given":"Michael","family":"McGee","sequence":"additional","affiliation":[{"name":"Cardiology Department, Tamworth Rural Referral Hospital, Dean Street, North Tamworth, NSW 2340, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1161\/CIRCULATIONAHA.113.005119","article-title":"Worldwide epidemiology of atrial fibrillation: A Global Burden of Disease 2010 Study","volume":"129","author":"Chugh","year":"2014","journal-title":"Circulation"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1146\/annurev.nutr.012809.104804","article-title":"Iron homeostasis and the inflammatory response","volume":"30","year":"2010","journal-title":"Annu. 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Ars."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"100873","DOI":"10.1016\/j.mam.2020.100873","article-title":"Iron deficiency and supplementation in heart failure and chronic kidney disease","volume":"75","author":"Punj","year":"2020","journal-title":"Mol. Asp. Med."}],"container-title":["Medicina"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1648-9144\/58\/10\/1492\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:57:37Z","timestamp":1760144257000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1648-9144\/58\/10\/1492"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,19]]},"references-count":14,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2022,10]]}},"alternative-id":["medicina58101492"],"URL":"https:\/\/doi.org\/10.3390\/medicina58101492","relation":{},"ISSN":["1648-9144"],"issn-type":[{"type":"electronic","value":"1648-9144"}],"subject":[],"published":{"date-parts":[[2022,10,19]]}}}