{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T21:53:13Z","timestamp":1772142793528,"version":"3.50.1"},"reference-count":31,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2022,11,5]],"date-time":"2022-11-05T00:00:00Z","timestamp":1667606400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>The link between obstructive sleep apnea (OSA) and obesity, and their common comorbidities such as diabetes mellitus (DM) or cardiovascular diseases, is not fully understood. The aim of this study was to investigate the possible association of OSA severity in obese individuals with polysomnography-based sleep parameters, as well as C-reactive protein (CRP) and glycated hemoglobin (HbA1c) serum levels. Polysomnographic recordings and blood samples were retrospectively compared between a group of 23 adult obese individuals with mild OSA (apnea\u2013hypopnea index (AHI) = 7.5 (5.5\u201312.5)\/h, age = 42.57 \u00b1 11.44 years, 16 male, 7 female, body mass index (BMI) = 37.35 \u00b1 3.88 kg\/m2) and an age-, sex-, and BMI-matched group of individuals with moderate or severe OSA (AHI 41.5 (25.7\u201371.8)\/h, age = 43.43 \u00b1 11.96 years, 16 male, 7 female, BMI = 37.87 \u00b1 4.74 kg\/m2). All respiratory sleep-associated parameters were significantly higher in individuals with moderate and severe OSA compared to those with mild OSA. CRP levels did not differ between the two OSA severity groups. However, serum levels of HbA1c were significantly higher in the moderate\/severe OSA group. Therefore, OSA severity may have a significant impact on glycemic control in obese individuals. Additionally, OSA severity did not appear to be further associated with systemic inflammation in obese individuals. Obese individuals may benefit not only from lifestyle modification, but also from OSA screening and treatment, particularly to prevent DM-associated disorders and conditions.<\/jats:p>","DOI":"10.3390\/medicina58111602","type":"journal-article","created":{"date-parts":[[2022,11,7]],"date-time":"2022-11-07T03:02:22Z","timestamp":1667790142000},"page":"1602","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Obstructive Sleep Apnea Disrupts Glycemic Control in Obese Individuals"],"prefix":"10.3390","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2356-7494","authenticated-orcid":false,"given":"Christopher","family":"Seifen","sequence":"first","affiliation":[{"name":"Sleep Medicine Center & Department of Otolaryngology, Head and Neck Surgery, University Medical Center Mainz, 55131 Mainz, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes","family":"Pordzik","sequence":"additional","affiliation":[{"name":"Sleep Medicine Center & Department of Otolaryngology, Head and Neck Surgery, University Medical Center Mainz, 55131 Mainz, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6462-3763","authenticated-orcid":false,"given":"Katharina","family":"Ludwig","sequence":"additional","affiliation":[{"name":"Sleep Medicine Center & Department of Otolaryngology, Head and Neck Surgery, University Medical Center Mainz, 55131 Mainz, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7428-127X","authenticated-orcid":false,"given":"Katharina","family":"Bahr","sequence":"additional","affiliation":[{"name":"Sleep Medicine Center & Department of Otolaryngology, Head and Neck Surgery, University Medical Center Mainz, 55131 Mainz, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cornelia","family":"Schupp","sequence":"additional","affiliation":[{"name":"Sleep Medicine Center & Department of Otolaryngology, Head and Neck Surgery, University Medical Center Mainz, 55131 Mainz, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"Matthias","sequence":"additional","affiliation":[{"name":"Sleep Medicine Center & Department of Otolaryngology, Head and Neck Surgery, University Medical Center Mainz, 55131 Mainz, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7996-4034","authenticated-orcid":false,"given":"Perikles","family":"Simon","sequence":"additional","affiliation":[{"name":"Department of Sports Medicine, Disease Prevention and Rehabilitation, Johannes Gutenberg University, 55099 Mainz, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7299-7346","authenticated-orcid":false,"given":"Haralampos","family":"Gouveris","sequence":"additional","affiliation":[{"name":"Sleep Medicine Center & Department of Otolaryngology, Head and Neck Surgery, University Medical Center Mainz, 55131 Mainz, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e15","DOI":"10.4081\/ni.2011.e15","article-title":"Obstructive sleep apnea","volume":"3","author":"Ho","year":"2011","journal-title":"Neurol. Int."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/S0140-6736(02)09464-3","article-title":"Obstructive sleep apnoea","volume":"360","author":"Malhotra","year":"2002","journal-title":"Lancet"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1001\/jama.295.13.1549","article-title":"Prevalence of overweight and obesity in the United States, 1999\u20132004","volume":"295","author":"Ogden","year":"2006","journal-title":"JAMA"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"2408","DOI":"10.1001\/archinte.165.20.2408","article-title":"Progression and regression of sleep-disordered breathing with changes in weight: The Sleep Heart Health Study","volume":"165","author":"Newman","year":"2005","journal-title":"Arch. Intern. Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"3015","DOI":"10.1001\/jama.284.23.3015","article-title":"Longitudinal study of moderate weight change and sleep-disordered breathing","volume":"284","author":"Peppard","year":"2000","journal-title":"JAMA"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1152\/japplphysiol.00587.2005","article-title":"Excess weight and sleep-disordered breathing","volume":"99","author":"Young","year":"2005","journal-title":"J. Appl. Physiol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1016\/S0735-1097(03)00184-0","article-title":"Obstructive sleep apnea and cardiovascular disease","volume":"41","author":"Lattimore","year":"2003","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1177\/1479972313516882","article-title":"The effect of continuous positive airway pressure on metabolic variables in patients with obstructive sleep apnoea","volume":"11","author":"Schlatzer","year":"2014","journal-title":"Chronic Respir. Dis."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"126","DOI":"10.3389\/fneur.2012.00126","article-title":"Obstructive sleep apnea and type 2 diabetes: Is there a link?","volume":"3","author":"Pamidi","year":"2012","journal-title":"Front. Neurol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.dsx.2012.09.013","article-title":"Continuous positive airway pressure and type 2 diabetes mellitus","volume":"6","author":"Chakhtoura","year":"2012","journal-title":"Diabetol. Metab. Syndr."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"3429","DOI":"10.1007\/s00405-016-4103-5","article-title":"Systemic inflammation in patients with compromised upper airway anatomy and primary snoring or mild obstructive sleep apnea","volume":"273","author":"Jahn","year":"2016","journal-title":"Eur. Arch. Oto-Rhino-Laryngol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1093\/sleep\/30.6.723","article-title":"The effect of acute intermittent hypercapnic hypoxia treatment on IL-6, TNF-alpha, and CRP levels in piglets","volume":"30","author":"Tam","year":"2007","journal-title":"Sleep"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"477","DOI":"10.12659\/MSM.893175","article-title":"Evaluation of the association of sleep apnea-related systemic inflammation with CRP, ESR, and neutrophil-to-lymphocyte ratio","volume":"21","author":"Korkmaz","year":"2015","journal-title":"Med. Sci. Monit."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1093\/sleep\/32.2.150","article-title":"The new AASM criteria for scoring hypopneas: Impact on the apnea hypopnea index","volume":"32","author":"Ruehland","year":"2009","journal-title":"Sleep"},{"key":"ref_15","first-page":"19","article-title":"Obstructive Sleep Apnea and Obesity: Implications for Public Health","volume":"1","author":"Jehan","year":"2017","journal-title":"Sleep Med. Disord."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1164\/ajrccm\/148.2.462","article-title":"Pharyngeal fat in obstructive sleep apnea","volume":"148","author":"Shelton","year":"1993","journal-title":"Am. Rev. Respir. Dis."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1164\/rccm.200208-866OC","article-title":"Identification of upper airway anatomic risk factors for obstructive sleep apnea with volumetric magnetic resonance imaging","volume":"168","author":"Schwab","year":"2003","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"159","DOI":"10.2147\/NSS.S164488","article-title":"Use of blood biomarkers to screen for obstructive sleep apnea","volume":"10","author":"Fleming","year":"2018","journal-title":"Nat. Sci. Sleep"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Xu, S., Wan, Y., Xu, M., Ming, J., Xing, Y., An, F., and Ji, Q. (2015). The association between obstructive sleep apnea and metabolic syndrome: A systematic review and meta-analysis. BMC Pulm. Med., 15.","DOI":"10.1186\/s12890-015-0102-3"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1164\/rccm.200610-1527OC","article-title":"Intermittent hypoxia causes insulin resistance in lean mice independent of autonomic activity","volume":"175","author":"Iiyori","year":"2007","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"2741","DOI":"10.1007\/s40618-021-01602-8","article-title":"Postprandial glucose and HbA1c are associated with severity of obstructive sleep apnoea in non-diabetic obese subjects","volume":"44","author":"Cignarelli","year":"2021","journal-title":"J. Endocrinol. Investig."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1183\/09031936.00162713","article-title":"European Sleep Apnoea Database collaborators. Sleep apnoea severity independently predicts glycaemic health in nondiabetic subjects: The ESADA study","volume":"44","author":"Kent","year":"2014","journal-title":"Eur. Respir. J."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"e13331","DOI":"10.1111\/jsr.13331","article-title":"ESADA Collaborators. Positive airway pressure (PAP) treatment reduces glycated hemoglobin (HbA1c) levels in obstructive sleep apnea patients with concomitant weight loss: Longitudinal data from the ESADA","volume":"30","author":"Tasbakan","year":"2021","journal-title":"J Sleep Res."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"77","DOI":"10.5493\/wjem.v5.i2.77","article-title":"Obstructive sleep apnea syndrome and cardiovascular disease: The influence of C-reactive protein","volume":"5","author":"Bouloukaki","year":"2015","journal-title":"World J. Exp. Med."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"e6850","DOI":"10.1097\/MD.0000000000006850","article-title":"Is C-reactive protein a marker of obstructive sleep apnea?: A meta-analysis","volume":"96","author":"Li","year":"2017","journal-title":"Medicine"},{"key":"ref_26","first-page":"199","article-title":"Correlation between pentraxin-3 and endothelial dysfunction in obstructive sleep apnea syndrome","volume":"10","author":"Kanbay","year":"2015","journal-title":"Ann. Thorac. Surg."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1093\/sleep\/27.8.1507","article-title":"C-reactive protein and sleep-disordered breathing","volume":"27","author":"Guilleminault","year":"2004","journal-title":"Sleep"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1089\/jwh.2017.6819","article-title":"The Apnea-Hypopnea Index Underestimates Systemic Inflammation in Women with Sleep-Disordered Breathing","volume":"27","author":"Gouveris","year":"2018","journal-title":"J. Women\u2019s Health"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Rocchi, C., Valentina, C., Totaro, V., Broggi, S., Lattanzi, S., Viticchi, G., Falsetti, L., Silvestrini, M., and Buratti, L. (2022). Inflammation markers in moderate and severe obstructive sleep apnea: The influence of sex. Sleep Breath., ahead of print.","DOI":"10.1007\/s11325-021-02537-3"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"492","DOI":"10.2174\/1871527320666211022104140","article-title":"Sex-Related Differences in Polygraphic Parameters in a Population of Patients with Obstructive Sleep Apnea Syndrome","volume":"21","author":"Buratti","year":"2022","journal-title":"CNS Neurol. Disord. Drug Targets"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"180097","DOI":"10.1183\/16000617.0097-2018","article-title":"Obesity hypoventilation syndrome","volume":"28","author":"Masa","year":"2019","journal-title":"Eur. Respir. Rev."}],"container-title":["Medicina"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1648-9144\/58\/11\/1602\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:11:13Z","timestamp":1760145073000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1648-9144\/58\/11\/1602"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,5]]},"references-count":31,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2022,11]]}},"alternative-id":["medicina58111602"],"URL":"https:\/\/doi.org\/10.3390\/medicina58111602","relation":{},"ISSN":["1648-9144"],"issn-type":[{"value":"1648-9144","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,5]]}}}