{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T03:47:53Z","timestamp":1790221673075,"version":"4.1.0"},"reference-count":24,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2022,11,10]],"date-time":"2022-11-10T00:00:00Z","timestamp":1668038400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Primary cutaneous lymphomas are a heterogeneous group of T-cell (CTCL) and B-cell lymphomas (CBCL) developing in the skin and without signs of extracutaneous disease at the time of diagnosis. The term \u201cprimary small\/medium CD4+ T-cell lymphoma\u201d was changed to \u201cprimary small\/medium cutaneous CD4+ lymphoproliferative disorder\u201d due to its indolent clinical behavior and uncertain malignant potential. This paper presents a rare case of primary cutaneous lymphoma with small to medium CD4+ T-cells. A 37-year-old patient presented with a tumor in the frontal region that had occurred approximately 8\u20139 months earlier. The tumor had a diameter of about 8\u20139 mm, well demarcated macroscopically, it was round in shape, about 6\u20137 mm high, pink in color, firm in consistency and painless during palpation. Surgical excision of the tumor was performed with a margin of safety of 8 mm and deep to the level of the frontal muscle fascia. The histopathological examination supported the diagnosis of cutaneous lymphoproliferation with a nodular disposition in the reticular dermis and extension around the follicular epithelia and sweat glands, composed mainly of dispersed medium-large lymphocytes. Additional immunohistochemical examination was requested. Immunohistochemical examination confirmed the diagnosis of \u201cprimary cutaneous CD4+ small\/medium T-cell lymphoproliferative disorder.\u201d Patient monitoring was carried out through clinical dermatological controls at 3, 6, and 12 months. After one year, a cranio-cerebral MRI was performed. For the following 5 years, an annual dermatological examination accompanied by cranio-cerebral MRI, blood count, and pulmonary X-ray were recommended. Similarly to all solitary skin lesions, the prognosis is excellent in this case, the only treatment being surgical excision.<\/jats:p>","DOI":"10.3390\/medicina58111618","type":"journal-article","created":{"date-parts":[[2022,11,10]],"date-time":"2022-11-10T02:01:45Z","timestamp":1668045705000},"page":"1618","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Surgical, Dermatological and Morphopathological Considerations in the Diagnosis and Treatment of Cutaneous Lymphoproliferative Tumors, Primary CD4+"],"prefix":"10.3390","volume":"58","author":[{"given":"Valeriu","family":"Ardeleanu","sequence":"first","affiliation":[{"name":"Doctoral School, Faculty of Medecine, \u201cOvidius\u201d University, 1 University Alley Street, Corp B, 900470 Constanta, Romania"},{"name":"General Hospital \u201cC\u0103i Ferate\u201d, 4-6 Alexandru Morutzi Street, 800223 Gala\u021bi, Romania"},{"name":"Arestetic Clinic, 78 Brailei Street, BR4A, 800108 Gala\u021bi, Romania"},{"name":"Faculty of Kinesiotherapy, University \u201cDun\u0103rea de Jos\u201d, 47 Domneasc\u0103 Street, 800008 Gala\u021bi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9688-0580","authenticated-orcid":false,"given":"Lavinia-Alexandra","family":"Moroianu","sequence":"additional","affiliation":[{"name":"\u201cElisabeta Doamna\u201d Psychiatry Hospital, 290 Traian Street, 800179 Gala\u021bi, Romania"},{"name":"Clinical Medical Department, Faculty of Medicine and Pharmacy, \u201cDun\u0103rea de Jos\u201d University, 47 Domneasc\u0103 Street, 800008 Gala\u021bi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anca","family":"Sava","sequence":"additional","affiliation":[{"name":"Department of Morpho-Functional Sciences I, Faculty of Medicine, University of Medicine and Pharmacy \u201cGr. T. Popa\u201d, 16 Universitatii Street, 700115 Iasi, Romania"},{"name":"Department of Pathology, \u201cProf. Dr. Nicolae Oblu\u201d Emergency Clinical Hospital, 2 Ateneului Street, 700309 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiberiu","family":"Tebeica","sequence":"additional","affiliation":[{"name":"Leventer Medical Center, 8 Monetariei Street, 011216 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4294-8911","authenticated-orcid":false,"given":"Radu Cristian","family":"Jecan","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery and Reconstructive Microsurgery, \u201cCarol Davila\u201d University of Medecine and Pharmacy, 8 Eroii Sanitari Street, 050474 Bucharest, Romania"},{"name":"Clinical Department of Plastic Surgery and Reconstructive Microsurgery, \u201cProf. Dr. Agrippa Ionescu\u201d Emergency Clinical Hospital, 7 Architect Ion Mincu Street, 011356 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marius","family":"Moroianu","sequence":"additional","affiliation":[{"name":"Department of Dental Medicine, Faculty of Medicine and Pharmacy, \u201cDun\u0103rea de Jos\u201d University, 47 Domneasc\u0103 Street, 800008 Gala\u021bi, Romania"},{"name":"Medical Assistance Service of the Municipality of Gala\u021bi, 97 Traian Street, 006757 Gala\u021bi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4290-7068","authenticated-orcid":false,"given":"Alin Laurentiu","family":"Tatu","sequence":"additional","affiliation":[{"name":"Clinical Medical Department, Faculty of Medicine and Pharmacy, \u201cDun\u0103rea de Jos\u201d University, 47 Domneasc\u0103 Street, 800008 Gala\u021bi, Romania"},{"name":"Dermatology Department, \u201cSfanta Cuvioasa Parascheva\u201d Clinical Hospital of Infectious Diseases, 393 Traian Street, 800179 Gala\u021bi, Romania"},{"name":"Multidisciplinary Integrated Center of Dermatological Interface Research MIC-DIR (Centrul Integrat Multidisciplinar de Cercetare de Interfata Dermatologica\u2014CIM-CID), \u201cDun\u0103rea de Jos\u201d University, 47 Domneasc\u0103 Street, 800008 Gala\u021bi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1182\/blood-2018-11-881268","article-title":"The 2018 update of the WHO-EORTC classification for primary cutaneous lymphomas","volume":"133","author":"Willemze","year":"2019","journal-title":"Blood"},{"key":"ref_2","first-page":"9367","article-title":"Angiogenesis as Prospective Molecular Biology Technique for Cancer Study","volume":"19","author":"Ardeleanu","year":"2014","journal-title":"Rom. 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