{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T21:53:28Z","timestamp":1791928408662,"version":"4.3.4"},"reference-count":72,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2022,11,10]],"date-time":"2022-11-10T00:00:00Z","timestamp":1668038400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"The Doctoral School of \u2018Grigore T. Popa\u2019 University of Medicine and Pharmacy, Iasi, Romania","award":["35\/1.02.2021"],"award-info":[{"award-number":["35\/1.02.2021"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: Diabetes mellitus (DM) is a complex disease affecting the whole metabolic balance of the body and resulting in multiple organ complications: cardiovascular, neuronal, renal, etc. Our study focuses on investigating the effect of zinc chloride (Zn) on certain blood parameters suggestive for assessing the metabolic disturbances, the liver and kidney function, the oxidative stress and the immune defense capacity in experimental-induced DM with streptozotocin (STZ) and cholesterol in rats. Materials and Methods: The animals were assigned to three groups, as follows: Group 1 (Control): buffer citrate solution 0.1 mL\/100 g body; Group 2 (STZ): 20 mg\/kg body STZ and fat diet (10 g cholesterol\/100 g diet); Group 3 (STZ+Zn): 20 mg\/kg body STZ + 5 mg\/kg body Zn chloride and the same fat diet. DM was induced by administering STZ in a single take daily, for three consecutive days, Zn and citrate buffer were administered orally for a month. The protocol was approved by the Ethics Committee of the University \u2018Grigore T Popa\u2019 Iasi, in agreement with the International Regulations about the handling of laboratory animals. Results: The use of STZ in rats fed with cholesterol was correlated with important weight gain, hyperglycemia, the intensification of the transaminases activity and the increase in serum alkaline phosphatase, cholesterol, triglyceride, urea, creatinine and in malondialdehyde. Conclusions: The treatment with Zn resulted in weight loss and a decrease in blood sugar in diabetic rats. Supplementation with Zn notably reduced oxidative stress, preserved the pancreatic architecture and restored the liver and kidney function and structure in STZ-induced DM in rats.<\/jats:p>","DOI":"10.3390\/medicina58111620","type":"journal-article","created":{"date-parts":[[2022,11,10]],"date-time":"2022-11-10T02:01:45Z","timestamp":1668045705000},"page":"1620","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Zinc Chloride Enhances the Antioxidant Status, Improving the Functional and Structural Organic Disturbances in Streptozotocin-Induced Diabetes in Rats"],"prefix":"10.3390","volume":"58","author":[{"given":"Irina Claudia","family":"Anton","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Clinical Pharmacology and Algesiology, Faculty of Medicine, \u2018Grigore T. Popa\u2019 University of Medicine and Pharmacy, Universitatii St. 16, 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7983-3811","authenticated-orcid":false,"given":"Liliana","family":"Mititelu-Tartau","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Clinical Pharmacology and Algesiology, Faculty of Medicine, \u2018Grigore T. Popa\u2019 University of Medicine and Pharmacy, Universitatii St. 16, 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eliza Gratiela","family":"Popa","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Technology, Faculty of Pharmacy, \u2018Grigore T. Popa\u2019 University of Medicine and Pharmacy, Universitatii St. 16, 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0370-2748","authenticated-orcid":false,"given":"Mihaela","family":"Poroch","sequence":"additional","affiliation":[{"name":"Department of Family Medicine, Preventive Medicine and Interdisciplinarity, Faculty of Medicine, \u2018Grigore T. Popa\u2019 University of Medicine and Pharmacy, Universitatii St. 16, 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2503-5395","authenticated-orcid":false,"given":"Vladimir","family":"Poroch","sequence":"additional","affiliation":[{"name":"2nd Department of Internal Medicine, Faculty of Medicine, \u2018Grigore T. Popa\u2019 University of Medicine and Pharmacy, Universitatii St. 16, 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5568-3780","authenticated-orcid":false,"given":"Ana-Maria","family":"Pelin","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Faculty of Medicine and Pharmacy, \u2018Dun\u0103rea de Jos\u2019 University, 800010 Gala\u021bi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liliana Lacramioara","family":"Pavel","sequence":"additional","affiliation":[{"name":"Department of Morphological and Functional Sciences, Faculty of Medicine and Pharmacy, \u2018Dun\u0103rea de Jos\u2019 University, 800010 Gala\u021bi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilie Cristian","family":"Drochioi","sequence":"additional","affiliation":[{"name":"Surgical Department, Faculty of Dental Medicine, University of Medicine and Pharmacy, 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gina Eosefina","family":"Botnariu","sequence":"additional","affiliation":[{"name":"Department of Diabetes, Nutrition and Metabolic Disease, \u2018Grigore T. Popa\u2019 University of Medicine and Pharmacy, Universitatii St. 16, 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1038\/s41574-022-00669-4","article-title":"Pathophysiology, phenotypes and management of type 2 diabetes mellitus in Indian and Chinese populations","volume":"18","author":"Ke","year":"2022","journal-title":"Nat. Rev. Endocrinol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"3567","DOI":"10.2147\/DMSO.S319895","article-title":"A review of current trends with type 2 diabetes epidemiology, aetiology, pathogenesis, treatments and future perspectives","volume":"14","author":"Reed","year":"2021","journal-title":"Diabetes Metab. Syndr. 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