{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T16:02:22Z","timestamp":1792598542249,"version":"4.5.0"},"reference-count":12,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2022,11,16]],"date-time":"2022-11-16T00:00:00Z","timestamp":1668556800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: Cervical squamous cell carcinoma (SCC) usually showed an infiltrative growth pattern into endocervical stroma. In rare cases, SCC spreads superficially as an intraepithelial lesion to proximal uterine segments, and more rarely, involves invasive and more aggressive behavior on secondary sites. Materials and Methods: In this study, we present the case of an interesting form of cervical SCC growth and we discuss the possible reasons for that presentation. Results: After clinical examination and repeated histomorphological analysis, we found remarkable cervical epithelial dysplasia (a high-grade squamous intraepithelial lesion\u2014H-SIL). A histopathology report after conization and hysterectomy showed squamocellular carcinoma with microinvasive focuses. Interestingly, squamocellular carcinoma was found in the proximal uterine and adnexal structure, as well as intraepithelial and microinvasive lesions. Conclusions: Our study described a rare presentation of primary cervical SCC with unusual adnexal involvement. This pattern of tumor growth should be especially considered for patients who are proposed for sparing surgical procedures. A detailed and multidisciplinary approach for every patient is very important because unpredictable cases are present. However, they are rare.<\/jats:p>","DOI":"10.3390\/medicina58111655","type":"journal-article","created":{"date-parts":[[2022,11,16]],"date-time":"2022-11-16T02:27:34Z","timestamp":1668565654000},"page":"1655","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Curious Case of Superfitial Spreading Cervical Squamocellular Carcinoma with Adnexal Involvement"],"prefix":"10.3390","volume":"58","author":[{"given":"Milan","family":"Doki\u0107","sequence":"first","affiliation":[{"name":"Clinic for Gynecology and Obstetrics, University Clinical Center of Serbia, 11000 Belgrade, Serbia"},{"name":"Medical Faculty, University of Belgrade, 11000 Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Svetlana","family":"Milenkovi\u0107","sequence":"additional","affiliation":[{"name":"Department of Pathology and Medical Cytology, University Clinical Center of Serbia, 11000 Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1931-4475","authenticated-orcid":false,"given":"Ljubi\u0161a","family":"Jovanovi\u0107","sequence":"additional","affiliation":[{"name":"Department of Pathology and Medical Cytology, University Clinical Center of Serbia, 11000 Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1994-8825","authenticated-orcid":false,"given":"Branislav","family":"Milo\u0161evi\u0107","sequence":"additional","affiliation":[{"name":"Clinic for Gynecology and Obstetrics, University Clinical Center of Serbia, 11000 Belgrade, Serbia"},{"name":"Medical Faculty, University of Belgrade, 11000 Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luka","family":"Andri\u0107","sequence":"additional","affiliation":[{"name":"Clinic for Gynecology and Obstetrics, University Clinical Center of Serbia, 11000 Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6640-234X","authenticated-orcid":false,"given":"Du\u0161an","family":"\u0160aponjski","sequence":"additional","affiliation":[{"name":"Center for Radiology Imaging-Magnetic Resonance, University Clinical Center of Serbia, 11000 Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vesna","family":"Kesi\u0107","sequence":"additional","affiliation":[{"name":"Clinic for Gynecology and Obstetrics, University Clinical Center of Serbia, 11000 Belgrade, Serbia"},{"name":"Medical Faculty, University of Belgrade, 11000 Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1097\/PGP.0000000000000206","article-title":"Secondary Involvement of the Adnexa and Uterine Corpus by Carcinomas of the Uterine Cervix: A Detailed Morphologic Description","volume":"34","author":"Reyes","year":"2015","journal-title":"Int. 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Case Rep."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1097\/00004347-200110000-00007","article-title":"Simultaneous Squamous Cell Carcinomas of the Uterine Cervix and Upper Genital Tract: Loss of Heterozygosity Analysis Demonstrates Clonal Neoplasms of Cervical Origin","volume":"20","author":"Kushima","year":"2001","journal-title":"Int. J. Gynecol. Pathol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1038\/s41580-020-0237-9","article-title":"Guidelines and definitions for research on epithelial\u2013mesenchymal transition","volume":"21","author":"Yang","year":"2020","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1097\/PGP.0000000000000603","article-title":"Transtubal Spread of a Superficially Invasive Cervical Adenocarcinoma to the Ovaries After 11 Years","volume":"39","author":"Abozina","year":"2020","journal-title":"Int. J. Gynecol. 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