{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T22:21:44Z","timestamp":1789424504512,"version":"build-2803163510"},"reference-count":44,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2022,11,18]],"date-time":"2022-11-18T00:00:00Z","timestamp":1668729600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico\u2014Research Productivity Fellowship","doi-asserted-by":"publisher","award":["310856\/2020-5"],"award-info":[{"award-number":["310856\/2020-5"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico\u2014Research Productivity Fellowship","doi-asserted-by":"publisher","award":["001"],"award-info":[{"award-number":["001"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior\u2014Brasil (CAPES)","doi-asserted-by":"publisher","award":["310856\/2020-5"],"award-info":[{"award-number":["310856\/2020-5"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior\u2014Brasil (CAPES)","doi-asserted-by":"publisher","award":["001"],"award-info":[{"award-number":["001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Objectives: The aim of this study was to evaluate neurodevelopmental outcomes (motor development, nonverbal intelligence, and attention) in children with cyanotic congenital heart disease (CHD) compared with healthy children from a public hospital in southern Brazil. Materials and Methods: This was a cross-sectional study with pediatric patients of both sexes: 37 children with cyanotic CHD and a control group with 38 healthy children. Parents\/guardians undertook a questionnaire and the SNAP IV scale (to evaluate attention) was applied. Two instruments were applied to each child: the R-2 Non-Verbal Intelligence test and the motor development scale. To assess the factors associated with insufficient performance in the three fields of neurodevelopment, a Poisson regression analysis was performed with a robust estimate. Results: There were no significant differences between children with cyanotic CHD and the control group for any of the neurodevelopmental outcomes studied. Low socioeconomic class was a factor associated with worse performance on the intelligence test and inattention. Furthermore, age was a factor for performance on the intelligence test, while a greater number of siblings was a factor associated with worse performance on the attention test. Conclusions: Public policies regarding child health must involve prioritizing the improvement of families\u2019 social conditions.<\/jats:p>","DOI":"10.3390\/medicina58111669","type":"journal-article","created":{"date-parts":[[2022,11,18]],"date-time":"2022-11-18T03:31:10Z","timestamp":1668742270000},"page":"1669","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Neurodevelopmental Outcomes among Brazilian Children with Cyanotic Congenital Heart Disease and Its Associated Factors"],"prefix":"10.3390","volume":"58","author":[{"given":"Fl\u00e1via Sara\u00e7ol","family":"Vignol","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Universidade Federal do Rio Grande\u2014FURG, Rio Grande 96203-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priscila","family":"Aikawa","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Universidade Federal do Rio Grande\u2014FURG, Rio Grande 96203-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatiane Britto","family":"da Silveira","sequence":"additional","affiliation":[{"name":"School Hospital, Universidade Federal de Pelotas, Pelotas 96020-360, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2436-4186","authenticated-orcid":false,"given":"Ronan Adler","family":"Tavella","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Universidade Federal do Rio Grande\u2014FURG, Rio Grande 96203-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinita","family":"Mahtani-Chugani","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n HUNSC y Gerencia de Atenci\u00f3n Primaria de Tenerife, 38200 Santa Cruz de Tenerife, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6788-4435","authenticated-orcid":false,"given":"Em\u00edlio J.","family":"Sanz","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Pharmacology, Universidad de La Laguna, 38200 Santa Cruz de Tenerife, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7344-4679","authenticated-orcid":false,"given":"Flavio Manoel Rodrigues","family":"da Silva J\u00fanior","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Universidade Federal do Rio Grande\u2014FURG, Rio Grande 96203-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1007\/s12013-015-0551-6","article-title":"Congenital heart disease: Causes, diagnosis, symptoms, and treatments","volume":"72","author":"Sun","year":"2015","journal-title":"Cell Biochem. 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