{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T09:17:42Z","timestamp":1770887862955,"version":"3.50.1"},"reference-count":65,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2022,11,23]],"date-time":"2022-11-23T00:00:00Z","timestamp":1669161600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Agents of platinum-based chemotherapy, such as cisplatin or carboplatin, are used in the treatment of a wide range of malignancies that affect children, such as brain tumors, osteosarcoma, neuroblastoma, hepatoblastoma, and germ cell tumors (GCTs). The Cyclophosphamide Equivalent Dose (CED) calculator for reproductive risk does not take platinum-based chemotherapy into account, despite the fact that it accounts for the majority of chemotherapy medications that are typically administered for pediatric GCTs. As a result, exposure to platinum-based drugs throughout infancy can have predictable long-term effects such as infertility, as well as other rare encounters such as lipoma formation and lipomatosis. Lipomas are the most prevalent benign soft tissue tumor subtype. They may be either solitary entities or engaged in multiple lipomatosis, which may have a familial origin or be an acquired disorder. Chemotherapy is a possible cause of lipomatosis. Chemotherapy based on cisplatin has been linked to a variety of long-term consequences, including kidney damage, neurotoxicity, and pulmonary toxicity, and may even create secondary cancers. However, lipoma development is known to occur in fewer than 1 in 100 individuals, and only a few examples of multiple cutaneous lipomatosis triggered by this therapy have been documented. Here we present a very rare case of lipomatosis in a pediatric patient with GCT under cisplatin therapy, which might be the third report of this kind affecting children.<\/jats:p>","DOI":"10.3390\/medicina58121715","type":"journal-article","created":{"date-parts":[[2022,11,24]],"date-time":"2022-11-24T01:46:56Z","timestamp":1669254416000},"page":"1715","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Insights on Lipomatosis after Platinum-Based Chemotherapy Use in Pediatric Oncology: A Case Report"],"prefix":"10.3390","volume":"58","author":[{"given":"Estera","family":"Boeriu","sequence":"first","affiliation":[{"name":"Department of Pediatrics, \u201cVictor Babes\u201d University of Medicine and Pharmacy, Eftimie Murgu Square 2, 300041 Timisoara, Romania"},{"name":"Department of Oncology and Haematology, \u201cLouis Turcanu\u201d Emergency Clinical Hospital for Children, Iosif Nemoianu Street 2, 300011 Timisoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra Georgiana","family":"Boc","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, \u201cVictor Babes\u201d University of Medicine and Pharmacy, Eftimie Murgu Square 2, 300041 Timisoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Borda","sequence":"additional","affiliation":[{"name":"Department of Oncology and Haematology, \u201cLouis Turcanu\u201d Emergency Clinical Hospital for Children, Iosif Nemoianu Street 2, 300011 Timisoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodica Anamaria","family":"Negrean","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Pharmacy, University of Oradea, 410073 Oradea, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bogdan","family":"Feciche","sequence":"additional","affiliation":[{"name":"Department of Urology, Satu-Mare County Emergency Hospital, Strada Ravensburg 2, 440192 Satu-Mare, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amalia Iulia","family":"Boeriu","sequence":"additional","affiliation":[{"name":"Klinikum Landshut, Teaching Hospital of the LMU Munich, Clinic for Anaesthesiology, Intensive Care Medicine and Pain Therapy, Robert-Koch-Strasse, 184034 Landshut, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6133-0204","authenticated-orcid":false,"given":"Florin George","family":"Horhat","sequence":"additional","affiliation":[{"name":"Multidisciplinary Research Center on Antimicrobial Resistance (MULTI-REZ), Microbiology Department, \u201cVictor Babes\u201d University of Medicine and Pharmacy, 300041 Timisoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ion Cristian","family":"Mot","sequence":"additional","affiliation":[{"name":"Department of Ear-Nose-Throat, \u201cVictor Babes\u201d University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square 2, 300041 Timisoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7210-1263","authenticated-orcid":false,"given":"Ioana Delia","family":"Horhat","sequence":"additional","affiliation":[{"name":"Department of Ear-Nose-Throat, \u201cVictor Babes\u201d University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square 2, 300041 Timisoara, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Madhavi","family":"Ravulapalli","sequence":"additional","affiliation":[{"name":"Bhaskar Medical College, Amdapur Road 156-162, Hyderabad 500075, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omar","family":"Sabuni","sequence":"additional","affiliation":[{"name":"Faculty of General Medicine, Altinbas University, Dilmenler Cd., 34217 Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6147-6518","authenticated-orcid":false,"given":"Abduljabar","family":"Adi","sequence":"additional","affiliation":[{"name":"Faculty of General Medicine, Baskent University, Fatih Sultan, 06790 Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adnan","family":"Anjary","sequence":"additional","affiliation":[{"name":"Faculty of General Medicine, Yeditepe University, Kay\u0131sdag\u0131 Cd., 34755 Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Smaranda Teodora","family":"Arghirescu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, \u201cVictor Babes\u201d University of Medicine and Pharmacy, Eftimie Murgu Square 2, 300041 Timisoara, Romania"},{"name":"Department of Oncology and Haematology, \u201cLouis Turcanu\u201d Emergency Clinical Hospital for Children, Iosif Nemoianu Street 2, 300011 Timisoara, 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