{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T14:10:01Z","timestamp":1789740601075,"version":"4.0.1"},"reference-count":54,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2022,11,29]],"date-time":"2022-11-29T00:00:00Z","timestamp":1669680000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Shanghai Clinical Pharmacy Key Specialty Construction Project","award":["20194Y0202"],"award-info":[{"award-number":["20194Y0202"]}]},{"name":"Shanghai Clinical Pharmacy Key Specialty Construction Project","award":["2003-09"],"award-info":[{"award-number":["2003-09"]}]},{"name":"Shanghai Clinical Pharmacy Key Specialty Construction Project","award":["2203-04"],"award-info":[{"award-number":["2203-04"]}]},{"name":"Shanghai Clinical Pharmacy Key Specialty Construction Project","award":["2021YXFS02"],"award-info":[{"award-number":["2021YXFS02"]}]},{"name":"Research Project of Shanghai Municipal Health Commission","award":["20194Y0202"],"award-info":[{"award-number":["20194Y0202"]}]},{"name":"Research Project of Shanghai Municipal Health Commission","award":["2003-09"],"award-info":[{"award-number":["2003-09"]}]},{"name":"Research Project of Shanghai Municipal Health Commission","award":["2203-04"],"award-info":[{"award-number":["2203-04"]}]},{"name":"Research Project of Shanghai Municipal Health Commission","award":["2021YXFS02"],"award-info":[{"award-number":["2021YXFS02"]}]},{"name":"Medical Research Project of Hongkou District Health Commission","award":["20194Y0202"],"award-info":[{"award-number":["20194Y0202"]}]},{"name":"Medical Research Project of Hongkou District Health Commission","award":["2003-09"],"award-info":[{"award-number":["2003-09"]}]},{"name":"Medical Research Project of Hongkou District Health Commission","award":["2203-04"],"award-info":[{"award-number":["2203-04"]}]},{"name":"Medical Research Project of Hongkou District Health Commission","award":["2021YXFS02"],"award-info":[{"award-number":["2021YXFS02"]}]},{"name":"Tongji University Graduate Education Research and Reform Project","award":["20194Y0202"],"award-info":[{"award-number":["20194Y0202"]}]},{"name":"Tongji University Graduate Education Research and Reform Project","award":["2003-09"],"award-info":[{"award-number":["2003-09"]}]},{"name":"Tongji University Graduate Education Research and Reform Project","award":["2203-04"],"award-info":[{"award-number":["2203-04"]}]},{"name":"Tongji University Graduate Education Research and Reform Project","award":["2021YXFS02"],"award-info":[{"award-number":["2021YXFS02"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: Hypericum perforatum (HP) is widely used for depressive therapy. Nevertheless, the antidepressant effect and potential mechanism of hyperoside (Hyp), the main active component of HP, have not been determined. Materials and Methods: We performed ultra-performance liquid chromatography\u2013quadrupole-time-of-flight\u2013tandem mass spectrometry (UPLC-Q-TOF-MS\/MS) technology to analyze the components in HP. Using data mining and network pharmacology methods, combined with Cytoscape v3.7.1 and other software, the active components, drug-disease targets, and key pathways of HP in the treatment of depression were evaluated. Finally, the antidepressant effects of Hyp and the mechanism involved were verified in chronic-stress-induced mice. Results: We identified 12 compounds from HP. Hyp, isoquercetin, and quercetin are the main active components of HP. The Traditional Chinese Medicine Systems Pharmacology Database (TCMSP), the Analysis Platform, DrugBank, and other databases were analyzed using data mining, and the results show that the active components of HP and depression are linked to targets such as TNF-, IL-2, TLR4, and so on. A potential signaling pathway that was most relevant to the antidepressant effects of Hyp is the C-type lectin receptor signaling pathway. Furthermore, the antidepressant effects of Hyp were examined, and it is verified for the first time that Hyp significantly alleviated depressive-like behaviors in chronic-stress-induced mice, which may be mediated by inhibiting the NLRP1 inflammasome through the CXCL1\/CXCR2\/BDNF signaling pathway. Conclusion: Hyp is one of the main active components of HP, and Hyp has antidepressant effects through the NLRP1 inflammasome, which may be connected with the CXCL1\/CXCR2\/BDNF signaling pathway.<\/jats:p>","DOI":"10.3390\/medicina58121749","type":"journal-article","created":{"date-parts":[[2022,11,30]],"date-time":"2022-11-30T02:21:57Z","timestamp":1669774917000},"page":"1749","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["The Role and Mechanism of Hyperoside against Depression-like Behavior in Mice via the NLRP1 Inflammasome"],"prefix":"10.3390","volume":"58","author":[{"given":"Aoqi","family":"Song","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Shanghai Fourth People\u2019s Hospital, School of Medicine, Tongji University, Shanghai 200434, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenghua","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200080, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2529-3404","authenticated-orcid":false,"given":"Wenjuan","family":"Zhao","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenqing","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Shanghai Fourth People\u2019s Hospital, School of Medicine, Tongji University, Shanghai 200434, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ru","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Shanghai Fourth People\u2019s Hospital, School of Medicine, Tongji University, Shanghai 200434, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Shanghai Fourth People\u2019s Hospital, School of Medicine, Tongji University, Shanghai 200434, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuojun","family":"Ni","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Qu","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xijier","family":"Qiaolongbatu","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5141-5896","authenticated-orcid":false,"given":"Guorong","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200080, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuefen","family":"Lou","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Shanghai Fourth People\u2019s Hospital, School of Medicine, Tongji University, Shanghai 200434, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Hao, Y., Ge, H., Sun, M., and Gao, M.S. 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