{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T22:04:29Z","timestamp":1794002669972,"version":"4.8.0"},"reference-count":42,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2022,11,30]],"date-time":"2022-11-30T00:00:00Z","timestamp":1669766400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Buddhist Tzu Chi Medical Foundation","award":["TCMMP109-03-03(111)"],"award-info":[{"award-number":["TCMMP109-03-03(111)"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: The burden of osteoporosis is projected to increase. Identification and prompt intervention for osteoporotic fractures are important. Adjusting the Fracture Risk Assessment (FRAX\u00ae) tool with trabecular bone score (TBS) could improve risk prediction. However, little is known about whether TBS-adjusted FRAX\u00ae would change the proportion of individuals qualified for osteoporosis intervention. Therefore, the aim of the present study was to compare the proportions of Taiwanese adults who qualified for intervention, according to the FRAX\u00ae and TBS-adjusted FRAX\u00ae, with stratification by sex, age group, and glucose regulation status. Materials and Methods: A medical record review on adults 50\u201390 years who had undergone a general health examination in a regional hospital in Taiwan was conducted. FRAX\u00ae and TBS-adjusted FRAX\u00ae were calculated. FRAX\u00ae cut-points of \u2265 20% for major osteoporotic fracture and \u22653% for hip fracture were adopted to identify individuals qualified for osteoporosis intervention. Individuals were classified as prediabetes and diabetes if their HbA1c was 5.7\u20136.4% and &gt;6.4%, respectively. Results: A total of 8098 individuals with a mean age of 61.0 years were included. The proportion of men qualified for intervention for hip fracture was significantly lower according to TBS-adjusted FRAX\u00ae (17.2%) compared with FRAX\u00ae (20.7%) (p &lt; 0.001), with a similar pattern across all three age groups and in those with prediabetes. In contrast, the proportion of women qualified for intervention for major osteoporotic fracture was significantly higher according to TBS-adjusted FRAX\u00ae (4.6%) compared with FRAX\u00ae (3.7%) (p &lt; 0.001), particularly among those with prediabetes 60\u201369 years. Conclusions: TBS-adjusted FRAX\u00ae led to small but significant changes in the proportions of individuals qualified for intervention in specific age groups and glucose regulation status.<\/jats:p>","DOI":"10.3390\/medicina58121766","type":"journal-article","created":{"date-parts":[[2022,11,30]],"date-time":"2022-11-30T07:10:27Z","timestamp":1669792227000},"page":"1766","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Comparison of Trabecular Bone Score\u2013Adjusted Fracture Risk Assessment (TBS-FRAX) and FRAX Tools for Identification of High Fracture Risk among Taiwanese Adults Aged 50 to 90 Years with or without Prediabetes and Diabetes"],"prefix":"10.3390","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6325-046X","authenticated-orcid":false,"given":"Tzyy-Ling","family":"Chuang","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Chiayi 622401, Taiwan"},{"name":"Graduate Institute of Clinical Pharmacy, Tzu Chi University, Hualien 970374, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei-Hua","family":"Chuang","sequence":"additional","affiliation":[{"name":"Graduate Institute of Clinical Pharmacy, Tzu Chi University, Hualien 970374, Taiwan"},{"name":"Faculty of Pharmacy, National Yang-Ming Chiao Tung University, Taipei 112304, Taiwan"},{"name":"MacKay Junior College of Medicine, Nursing, and Management, New Taipei City 11260, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuh-Feng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Taipei Veterans General Hospital, Taipei 112021, Taiwan"},{"name":"Department of Medical Imaging and Radiological Technology, Yuanpei University of Medical Technology, Hsinchu 300102, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9242-9167","authenticated-orcid":false,"given":"Malcolm","family":"Koo","sequence":"additional","affiliation":[{"name":"Graduate Institute of Long-Term Care, Tzu Chi University of Science and Technology, Hualien 970302, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"S107","DOI":"10.1016\/S1297-319X(10)70004-X","article-title":"Osteoporosis and mortality","volume":"77","author":"Leboime","year":"2010","journal-title":"Jt. 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